Multifunctional contrast agent of oxygen carrying liquid fluorocarbon and preparation method thereof

A multi-functional, contrast agent technology, applied in the field of ultrasound imaging, can solve the problems of limiting and weakening the efficiency of ICG treatment, and achieve the effect of increasing the effect of photodynamic therapy, improving the effect of diagnosis and treatment, and improving anatomical information

Inactive Publication Date: 2018-08-10
CHONGQING MEDICAL UNIVERSITY
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Problems solved by technology

However, ICG is easily combined with plasma proteins in the body and is quickly cleared, and the circulation time in the body is only 3-4 minutes
In addition, the imaging function and therapeutic function of ICG are due to its multiple energy level conversion methods after laser excitation, including fluorescence pathway, non-radiative pathway (photothermal), third excited state (singlet oxygen), etc. These energy conversion modes Competing with each other, weakening the therapeutic efficiency of ICG
To make matters worse, the hypoxic state of the tumor site further limits the therapeutic efficiency of ICG, especially for oxygen-dependent photodynamic therapy.
Therefore, it is necessary and a great challenge to improve the therapeutic effect of ICG

Method used

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  • Multifunctional contrast agent of oxygen carrying liquid fluorocarbon and preparation method thereof
  • Multifunctional contrast agent of oxygen carrying liquid fluorocarbon and preparation method thereof
  • Multifunctional contrast agent of oxygen carrying liquid fluorocarbon and preparation method thereof

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Embodiment Construction

[0026] One, a kind of multifunctional contrast agent (abbreviation LIP-PFOB-ICG) of oxygen-carrying liquid fluorocarbon of the present invention, its specific preparation method is:

[0027] 1) Film formation: DPPC (Avanti, USA), distearoylphosphatidylethanolamine-polyethylene glycol 2000DSPE-PEG2000 (Avanti, USA), CHOL-cholesterol (Sangon Bioengineering (Shanghai) Co., Ltd.) 3: 1:1 Weigh a total of 10 mg into a round bottom flask, add 10 mL of chloroform at the same time, close the mouth of the round bottom flask, put it into 50 ° C water and heat until fully dissolved.

[0028] 2) Rotary evaporation: After dissolving for 20 minutes, fix the round-bottomed flask on a rotary evaporator (temperature: 50°C) and perform a rotary evaporation under reduced pressure to remove the organic solvent. Rotational speed: 80rpm, time: 2 hours, forming a layer of uniform white film .

[0029] 3) Ultrasonic cleaning: After evaporation, remove the round bottom flask, add 4mL double-distilled ...

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Abstract

The invention discloses a multifunctional contrast agent of oxygen carrying liquid fluorocarbon. The multifunctional contrast agent is of a spherical shell-core structure; the core is prepared from liquid fluorocarbon and indocyanine green. The invention aims at solving the technical problems to provide the multifunctional contrast agent of oxygen carrying liquid fluorocarbon and the preparation method. The multifunctional contrast agent has high biological safety and stability, and is used for the multi-mode nanometer contrast agent guided breast cancer light treatment.

Description

technical field [0001] The invention relates to the field of ultrasonic imaging, in particular to a preparation method and application of an oxygen-carrying liquid fluorocarbon multifunctional contrast agent. Background technique [0002] In recent years, diagnosis and treatment technologies that integrate diagnosis and treatment and make treatment plans more personalized have attracted everyone's attention. And due to the rapid development of nano-preparation technology, a variety of nano-materials have been able to successfully concentrate the functions of diagnosis and treatment in the same nano-material, giving birth to "nano-diagnosis and treatment technology". Among various treatment methods, phototherapy (including photothermal therapy and photodynamic therapy) has shown great advantages due to its non-invasiveness, high spatiotemporal controllability and high safety. Many phototherapy nano-therapeutic agents combined with various imaging techniques, such as magnetic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K9/50A61K41/00A61K49/00A61K49/04A61P15/14A61P35/00
CPCA61K9/5031A61K41/0057A61K49/0002A61K49/0034A61K49/0433A61K49/225
Inventor 王志刚盛丹丽冉海涛李攀
Owner CHONGQING MEDICAL UNIVERSITY
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