A method for the determination of 12 kinds of local anesthetics in cosmetics

A technology of local anesthetics and determination methods, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as coma, irregular heartbeat, high blood drug concentration, etc.

Active Publication Date: 2020-12-29
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Long-term use of cosmetics containing the above-mentioned local anesthetics will cause potential harm to human health, and may produce high blood drug concentrations, resulting in irregular heartbeat, seizures, and coma

Method used

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  • A method for the determination of 12 kinds of local anesthetics in cosmetics
  • A method for the determination of 12 kinds of local anesthetics in cosmetics
  • A method for the determination of 12 kinds of local anesthetics in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0050] 1. Reagents and materials

[0051] Methanol: chromatographically pure.

[0052] Ammonium bicarbonate and ammonium hydroxide: analytically pure.

[0053] 12 kinds of standard stock solutions of local anesthetics: Weigh an appropriate amount of standard stock solutions of local anesthetics (accurate to 0.0001 g), and prepare 1000 mg / L standard stock solutions with methanol solution.

[0054] Standard working solution of 12 kinds of local anesthetics: According to the difference in response intensity of 12 kinds of caine substances at the same concentration, divide them into two groups of concentration gradients to prepare mixed standard working solution. Standard stock solutions of six local anesthetics, benzocaine, lysocaine, chloroprocaine, butancaine, lidocaine, and cinbucaine, were prepared with methanol solution to concentrations of 0.1, 0.25, 0.5, 1, and 2.5 , 5, 10, 25, 50 mg / L standard working solutions; six kinds of procaine, procainamide, tetracaine, amicaine,...

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PUM

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Abstract

The invention discloses a method for determining 12 local anesthetics in cosmetic. The method comprises the following steps: 1) sample pre-treatment: preparing a supramolecular solvent, and pre-treating a cosmetic sample to obtain a filtrate; 2) performing determination on a filtrate by employing a high-performance liquid chromatography; and 3) drafting a standard curve, calculating the content of12 local anesthetics in a sample. The high-performance liquid chromatography is employed for determining the local anesthetics in the cosmetic, and a liquid chromatogram-mass spectrometry method is employed for affirmation of a positive sample. The method has the advantages of accuracy, rapidity, and high sensitivity; the detection limit, the recovery rate and precision accord with requirements,and the method has important meaning for safety monitoring for quality of the cosmetic.

Description

technical field [0001] The invention relates to a detection method of chemical substances, in particular to a detection method of 12 kinds of local anesthetics in cosmetics. Background technique [0002] Local anesthetics are a class of drugs that can reversibly block the generation and transmission of sensory nerve impulses locally. At present, commonly used local anesthetics can be divided into esters and amides, esters such as benzocaine, etc., amides such as lidocaine and so on. The chemical information of 12 local anesthetics involved in the present invention is shown in Table 1. [0003] Table 1 Substance information of 12 local anesthetics [0004] [0005] [0006] Long-term use of cosmetics containing the above-mentioned local anesthetics will cause potential harm to human health, and may produce high blood drug concentrations, resulting in irregular heartbeat, seizures, and coma. In my country's "Safety and Technical Specifications for Cosmetics" (2015 Edi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/34G01N30/72G01N30/06G01N30/14
CPCG01N30/02G01N30/06G01N30/14G01N30/34G01N30/72G01N2030/146
Inventor 马强王春郭项雨白桦
Owner CHINESE ACAD OF INSPECTION & QUARANTINE
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