A kind of cod skin gelatin composite hemostatic dressing and preparation method thereof

A technology of hemostatic dressing and skin gelatin, which is applied in the fields of medical formula, bandage, drug delivery, etc. It can solve the problem of inability to exert the synergistic effect of gelatin and sodium alginate, inability of platelet aggregation, adhesion and activation support, lack of three-dimensional network structure, etc. problems, to achieve good biodegradability, promote wound healing, and interconnected pores

Active Publication Date: 2021-08-13
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Invention patent CN 105854072 A discloses a medical gel and its method for preparing a medical external gel patch. The hydrophilic polymer material of this patent uses gelatin and / or sodium alginate, and the crosslinking agent is chloride Calcium or glutaraldehyde, the prepared medical gel has good hydrophilicity, but this invention patent is mainly used to eliminate edema and inflammation caused by intravenous administration, prevent phlebitis and soft tissue damage, and cannot and is not suitable for skin abrasions , trauma and internal bleeding
[0007] Invention patent CN 104784740 B discloses a method for preparing a composite medical dressing. In this patent, sodium alginate sponge is immersed in calcium chloride solution. This patent also involves pre-freezing and freeze-drying technology, but the invention patent is Sodium alginate is the main raw material, and the gelatin solution is only the carrier of antibacterial drugs, which cannot exert the synergistic effect after the compounding of gelatin and sodium alginate
[0008] Invention patent CN 104307031 B discloses a preparation method of external skin repair materials. In this patent, sodium alginate solution is mixed with gelatin solution, and then glutaraldehyde is also added. The gel-like medical dressing obtained directly after soaking and standing still has not undergone vacuum freeze-drying, lacks a three-dimensional network structure, and cannot provide support for the aggregation, adhesion and activation of platelets
[0010] Invention patent CN 105126152 B discloses a gelatin-chitosan composite hemostatic powder, which basically discloses the gelatin preparation method of the present application, and also discloses the final product disinfection and sterilization method, but the product obtained in this invention patent is in the form of powder , in the application process, there are problems such as easy to be washed away by blood, inconvenient to use, difficult to recycle and dust, which limit its scope of application

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  • A kind of cod skin gelatin composite hemostatic dressing and preparation method thereof
  • A kind of cod skin gelatin composite hemostatic dressing and preparation method thereof
  • A kind of cod skin gelatin composite hemostatic dressing and preparation method thereof

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preparation example Construction

[0042] A preparation method of cod skin gelatin composite hemostatic dressing, comprising the following steps:

[0043] (1) Pretreatment of cod skin: add the scaled and cleaned cod skin to soak in NaOH aqueous solution, then wash repeatedly with distilled water, then add HCl aqueous solution to soak until the cod skin swells, then wash with water until the pH is neutral .

[0044] (2) Extraction of cod skin gelatin: Drain the cod skin processed in step (1), add distilled water to mix, then shake and extract under constant temperature water bath conditions, then carry out centrifugation, take the upper layer solution and filter it with multi-layer gauze silk to obtain The filtrate was suction filtered while hot to obtain the cod skin gelatin solution, which was poured into a flat plate to freeze-dry to obtain the cod skin gelatin.

[0045] (3) Preparation of gelatin / sodium alginate composite solution: dissolve sodium alginate in distilled water and stir, then add the lyophiliz...

Embodiment 1

[0050] A preparation method of cod skin gelatin composite hemostatic dressing, comprising the following steps:

[0051] (1) Pretreatment of cod skin: thaw the frozen cod skin in running water, remove the muscle tissue and fat tissue, scrape off the fish scales, and clean it with clean water; use 100g of cod skin according to the ratio of material to liquid (w / v) of 1:10 Add 0.1mol / L NaOH aqueous solution for soaking treatment for 4h to remove impurities and pigments; then wash repeatedly with distilled water; After soaking in HCl aqueous solution for 2h until the cod skin swells, wash with water until the pH is neutral.

[0052] (2) Extraction of cod skin gelatin: Drain the cod skin treated in step (1) and mix it with distilled water according to the ratio of solid to liquid of 1:5, then shake and extract it in a constant temperature water bath at 50°C for 3 hours; then in 4200r Centrifuge for 15 min at a rotating speed of 1 / min, take the upper layer solution and filter it wi...

Embodiment 2

[0057] A preparation method of cod skin gelatin composite hemostatic dressing, comprising the following steps:

[0058] (1) Pretreatment of cod skin: thaw the frozen cod skin in running water, remove the muscle tissue and fat tissue, scrape off the fish scales, and wash it with clean water; add 100g cod skin according to the ratio of material to liquid (w / v) of 1:10 Soak in 0.1mol / L NaOH aqueous solution for 4 hours to remove impurities and pigments; then wash repeatedly with distilled water; then add 0.1mol / L HCl to the cod skin according to the solid-liquid ratio (w / v) of 1:6 After soaking in the aqueous solution for 2 hours until the cod skin swells, wash with water until the pH is neutral.

[0059] (2) Extraction of cod skin gelatin: Drain the cod skin treated in step (1) and mix it with distilled water according to the ratio of solid to liquid of 1:5, then shake and extract it in a constant temperature water bath at 40°C for 3 hours; then in 4200r Centrifugal 15min under...

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Abstract

The invention discloses a preparation method of cod skin gelatin composite hemostatic dressing, which comprises the following steps: (1) Preparation of gelatin / sodium alginate composite solution: dissolving sodium alginate in distilled water and stirring, then adding freeze-dried cod The gelatin is heated and stirred, and the gelatin / sodium alginate composite solution is obtained after vacuum degassing; (2) crosslinking: the gelatin / sodium alginate composite solution prepared in step (1) is subjected to a crosslinking reaction with a crosslinking agent; (3 ) Disinfection and sterilization: the product of step (2) is sterilized to obtain the cod skin gelatin composite hemostatic dressing. The hemostatic dressing prepared by the present invention is pure white as a whole, dense and free of impurities, and its physical properties are greatly improved, its tensile strength and water absorption are higher than those of existing products, its hemostatic performance reaches the hemostatic effect of existing products, and its microstructure is in a uniform porous shape , is suitable for cell adhesion, has good biocompatibility and in vivo degradability, and is a good biomedical dressing.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and in particular relates to a cod skin gelatin composite hemostatic dressing and a preparation method thereof. Background technique [0002] Skin is one of the vital organs of the human body. In daily life, situations such as trauma, abrasions, burns and skin ulcers often occur, causing skin damage. When the skin is damaged, that is, a major barrier of the human body against the environment is damaged, making the wound prone to infection, loss of protein and body fluids, etc., resulting in increased bleeding, affecting wound healing, and causing various complications in severe cases . Generally, wound dressings are required to stop bleeding quickly, reduce the amount of bleeding, protect the wound to a certain extent, and promote wound healing. And existing wound dressings, such as medical gauze, hemostatic cotton, hemostatic powder etc., still have problems such as long h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/62A61L15/42A61L15/20
CPCA61L15/20A61L15/225A61L15/42A61L15/425A61L15/62A61L2400/04C08L89/00C08L5/04
Inventor 侯虎李八方刘晗
Owner OCEAN UNIV OF CHINA
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