A Method for Guiding Micro-Nanomotors Using Magnetically Responsive Topological Orbitals

A micro-nano, motor technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for sensing, can solve the problems of microbial death, difficulty in applying biomedical fields, poor biocompatibility of ferromagnetic materials, etc., and achieve simplification The effect of the preparation process

Active Publication Date: 2019-07-12
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is effective, its large-scale production and practical application are hindered by the high cost and complicated and cumbersome steps of magnetic modification of micro-nano motors. At the same time, the ferromagnetic materials used in traditional methods are poor in biocompatibility and difficult to apply In the field of biomedicine, in addition, when controlling the movement of microorganisms, such an artificial modification process can easily lead to the death of microorganisms
On the other hand, when using methods such as local micro-patterns and micro-pipes to control the movement of micro-nano motors, since the patterns are pre-engraved on the substrate, the movement of the micro-nano motors can only be realized according to a predetermined route, and real-time regulation cannot be performed.

Method used

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  • A Method for Guiding Micro-Nanomotors Using Magnetically Responsive Topological Orbitals
  • A Method for Guiding Micro-Nanomotors Using Magnetically Responsive Topological Orbitals
  • A Method for Guiding Micro-Nanomotors Using Magnetically Responsive Topological Orbitals

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Fe used to form topological orbitals 3 o 4 @PVP nanoparticles, prepared according to the literature (Adv Mater 2014, 26(7), 1058-1064) using a solvothermal method, have superparamagnetism and monodispersity. The tubular micro-nanomotor prepared according to the literature was placed under a scanning electron microscope (SEM, S-4800, Hitachi Co., Ltd., Japan) for microscopic characterization.

[0033] SEM pictures of micro-nano motors taken by scanning electron microscope (SEM, S-4800, Hitachi Co., Ltd., Japan) figure 1 shown.

Embodiment 2

[0035] Orientation process of micro-nano motors:

[0036] Sodium cholate solution (this solution is a surfactant, similar effects can also be achieved with other surfactants), H 2 o 2 solution, Fe 3 o 4 @PVP nanoparticle suspension and tubular micro-nano motor suspension are mixed, and ultrasonic vibration is used to disperse them evenly. The H 2 o 2 Solution concentration is 7vt%, sodium cholate aqueous solution concentration is 0.5wt%, Fe 3 o 4 @PVP nanoparticles concentration is 94mg / mL.

[0037] Take an appropriate amount of the above liquid and drop it on the glass slide, and use a magnet to apply a directional magnetic field.

[0038] Utilize an inverted fluorescent microscope (LeicaDMI 3000M) to photograph the motion state of the micro-nano motor in Example 2, and intercept the motor motion timing diagram and schematic diagram as shown in figure 2 shown. It can be observed that when the topological orbit is not formed, the micro-nanomotor makes a circular motio...

Embodiment 3

[0040] Using a directional magnetic field to control the micro-nano motor to move along a predetermined trajectory experiment:

[0041] Sodium cholate solution, H 2 o 2 solution, Fe 3 o 4 @PVP nanoparticle suspension and tubular micro-nano motor suspension are mixed, and ultrasonic vibration is used to disperse them evenly. The H 2 o 2 Solution concentration is 6vt%, sodium cholate aqueous solution concentration is 0.4wt%, Fe 3 o 4 @PVP nanoparticles concentration is 75mg / mL.

[0042] Take an appropriate amount of the above-mentioned liquid and drop it on the glass slide, apply a directional magnetic field with a magnet, and change the direction of the magnetic field.

[0043] Utilize an inverted fluorescent microscope (LeicaDMI 3000M) to take pictures of the motion state of the micro-nano motor in Example 3, and intercept the timing diagram and motion trajectory diagram as image 3 shown. Under the action of a directional magnetic field, Fe 3 o 4 @PVP nanoparticle...

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Abstract

The present invention discloses a method for guiding micro-nano motor by employing a mangnetic responsiveness topology orbit. The method comprises the following steps of: dispersing magnetic particlesinto solution, and assembling the magnetic particles in a magnetic field to form a one-dimensional chain as a topology orbit; dispersing the magnetic particles into the solution, applying an externalmagnetic field, allowing the magnetic particles to perform orientation in a direction of a magnetic induction line to form a one-dimensional chain as a topology orbit; and changing the direction of an external magnetic field to change the direction of the topology orbit, and changing the switching state of the external magnetic field to control appearance or disappearance of the topology orbit soas to dynamically control the movement direction of the micro-nano motor. The method overcomes the defect that a traditional magnetic field control method needs to perform complex and high-cost construction for the micro-nano motor, does not need to perform extra processing of the micro-nano motor itself, simplifies the preparation process of the micro-nano motor, has a certain biocompatibility and can achieve dynamic real-time regulation and control of the nonmagnetic micro-nano motor without special construction and microorganism movement directions and tracks.

Description

technical field [0001] The invention belongs to the technical field of micro-nano motors, and relates to a motion control method of a micro-nano motor. Background technique [0002] A micro-nano motor is a tiny device that can convert other forms of energy into kinetic energy, realize its own movement in a liquid medium, and perform complex tasks at the same time. It is expected that micro-nano motors can bring about radical changes in the fields of micro-nano engineering, biomedicine, and environmental science (Chem Rev, 2015, 115(16), 8704; Nanoscale, 2011, 3(2), 557; Angew Chem Int Ed Engl, 2015, 54(5), 1414-1444). Due to the unique motion properties of micro-nano motors, they have great potential in performing complex tasks such as cargo transportation, microsurgery, and micro-nano manufacturing (Nanoscale2013, 5(11), 4696; Chem.Rev.2014, 114, 6285; Nanoscale Letter 2007, 5). In order to realize the practical application of micro-nano motors, it is necessary to contro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H02N11/00B82Y15/00
CPCB82Y15/00H02N11/006
Inventor 牟方志杨帆官建国
Owner WUHAN UNIV OF TECH
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