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Application of SNHG5 (small nucleolar RNA host gene 5) in diagnosis, evaluation and efficacy prediction of breast cancer

A breast cancer, curative effect technology, applied in the field of tumor molecular biology, can solve problems such as the impact of breast cancer has not been reported

Inactive Publication Date: 2018-08-31
TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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Problems solved by technology

However, there are few studies on lncRNA SNHG5, and its impact on breast cancer has not been reported.

Method used

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  • Application of SNHG5 (small nucleolar RNA host gene 5) in diagnosis, evaluation and efficacy prediction of breast cancer
  • Application of SNHG5 (small nucleolar RNA host gene 5) in diagnosis, evaluation and efficacy prediction of breast cancer
  • Application of SNHG5 (small nucleolar RNA host gene 5) in diagnosis, evaluation and efficacy prediction of breast cancer

Examples

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with specific embodiments and accompanying drawings. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0028] For the experimental methods that do not indicate specific conditions in the following examples, conventional methods in the art can be used, for example, with reference to "Molecular Cloning Experiment Guide" (third edition, New York, Cold Spring Harbor Laboratory Press, New York: Cold Spring Harbor Laboratory Press, 1989), or according to the conditions suggested by the supplier, such as the conditions recorded in the product specification.

[0029] Various instruments, raw materials and reagents not specifically described in the following examples are commercially available products well known in the art and can be obtained through commercial channels. The specific materials used ...

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Abstract

The invention discloses an application of SNHG5 (small nucleolar RNA host gene 5) in diagnosis, evaluation and efficacy prediction of breast cancer. It is found that lncRNA SNHG5 has significant low expression in breast cancer tissue and breast cancer cell lines, knockout of the lncRNA SNHG5 gene can enhance proliferation and migration of breast cancer cells and inhibit apoptosis, and thus, the expression level of long-chain non-coding RNA SNHG5 is closely related with diagnosis, transfer and relapse of tumor, patient prognosis and neoadjuvant chemotherapy effect are closely related, which indicates that the lncRNA SNHG5 gene can be used as a marker for diagnosis, prognosis evaluation or effect prediction. A breast cancer cell model which has low expression of SNHG5 and is established by transfecting breast cancer cell lines with small interference RNA can be used in a preparation method of a preparation for preventing relapse and transfer of breast cancer.

Description

technical field [0001] The invention belongs to the technical field of tumor molecular biology, and relates to a long-chain non-coding RNA SNHG5 (lncRNASNHG5) and an application thereof. Background technique [0002] Tumor is a common and frequently-occurring disease that endangers human health today, especially malignant tumors have become one of the main reasons that threaten human life. In recent years, breast cancer has become the number one "tumor killer" of women in the world, ranking first in the cause of death from malignant tumors in women. According to the "2012 Global Cancer Epidemiological Statistics" released by the International Agency for Research on Cancer under the World Health Organization, breast cancer is also the tumor with the highest incidence rate among women in my country, accounting for 15% of all female malignant tumors, seriously endangering women's physical and mental health. [0003] At present, in addition to pathological and imaging detection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/178
Inventor 孟旭莉李永峰刘小珍钱佳诚芮鑫淼吴志坚汤鸿超金淦
Owner TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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