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Repair and Strengthening of Artificial Biological Tissues

A biological tissue, artificial technology, applied in tissue regeneration, non-polymer organic compound adhesives, prostheses, etc., can solve the problems of leaflet discarding, heart valve discarding, etc.

Active Publication Date: 2021-03-09
MEDTRONIC VASCULAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Defective leaflets are often discarded during valve production, or defective heart valves are discarded at some other point before being used in a patient

Method used

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  • Repair and Strengthening of Artificial Biological Tissues
  • Repair and Strengthening of Artificial Biological Tissues
  • Repair and Strengthening of Artificial Biological Tissues

Examples

Experimental program
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Effect test

Embodiment Construction

[0014] The biological tissue used in the bioprosthetic valve can have selected regions that are strengthened as desired without altering the overall properties of the tissue (eg, flexibility, etc.). For example, tissue may have natural defects, such as openings or through-holes, which do not affect the performance or function of the valve. Perforation is a cosmetic defect and native porcine aortic root tissue is often discarded due to the natural perforation in the lobules. Additionally, defects such as suture holes can form in the tissue during the manufacturing process in valve assembly. It would be advantageous to reinforce or strengthen at these specific defect sites before the valve is implanted in the patient, and especially during valve manufacture. Additionally, it may be desirable to focally alter biological tissue to increase strength or stiffness at other selected locations in the tissue. Tissue augmentation can increase the availability of tissue and heart valves...

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Abstract

A method of strengthening or repairing artificial biological tissue used as artificial valve leaflets. The method includes evaluating the artificial biological tissue prior to implantation in a patient, identifying defects in the artificial biological tissue, and applying an adhesive to the surface of the artificial biological tissue at the site of the defect.

Description

Background technique [0001] There are many types and configurations of artificial heart valves used to replace diseased native human heart valves. The actual shape and configuration of any particular artificial heart valve depends to some extent on the valve being replaced (ie, mitral, tricuspid, aortic, or pulmonary). Typically, artificial heart valve designs attempt to replicate the function of the valve being replaced, and thus include valve leaflet-like structures that are used in conjunction with artificial biological heart valves or mechanical heart valve prostheses. [0002] Bioprostheses or "tissue valves" are usually made of suitable animal tissue or material (e.g. harvested porcine valve leaflets, bovine or equine pericardial leaflets, synthetic material leaflets, etc.) on a fixed metal or plastic frame called a "bracket". With or without a stent, prosthetic bio / synthetic heart valves are typically tubular (ie, the leaflets "open" to form internal channels through ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/24A61L27/50A61L27/26A61L27/36A61L24/04A61L24/10
CPCA61L27/3625A61L27/50A61L24/06A61L24/108A61F2220/0075A61L2430/40A61F2/2415A61F2/2412A61L27/507A61F2220/005A61L2430/20C08L35/04A61F2/2409A61L27/26C09J4/00C09J189/00
Inventor T·蒂恩C·艾伯哈德特K·加德B·黄W·王E·霍华德L·麦克林利K·欧尔尼T·温特斯
Owner MEDTRONIC VASCULAR INC