Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of fluid hemostatic glue and its preparation method and application

A fluid and gelatin technology, used in applications, pharmaceutical formulations, surgery, etc., can solve problems affecting wound healing, tissue irritation, etc., and achieve good hemostasis, easy operation, and increased adhesion.

Active Publication Date: 2021-08-31
MEDPRIN REGENERATIVE MEDICAL TECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this kind of fluid matrix has a certain clinical history, it is a kind of foreign body to the human body after all, and high levels can stimulate tissues and affect wound healing

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of fluid hemostatic glue and its preparation method and application
  • A kind of fluid hemostatic glue and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A fluid hemostatic glue, comprising a hemostatic effective component and a fluid matrix, the hemostatic effective component includes component A, component B and component C, wherein component A is 0.5g gelatin, and component B is 0.5g α-glycerin Sodium Phosphate, Component C is 0.5g polylysine, the fluid base consists of 10g saline and 0.5mg glycerin. Wherein the jelly strength of gelatin is 200 Bloom / g, and the source of gelatin is pig source.

[0036] The preparation method of the fluid hemostatic gel is as follows: Weigh 0.5g gelatin, 0.5g α-sodium glycerophosphate and 0.5g polylysine in a container, put in an ice bath, keep the temperature at 2°C, add 10g normal saline, and weigh another Add 0.5mg of glycerin into a container, stir to make it evenly mixed, take it out, put it into a container, and irradiate to obtain a fluid hemostatic gel product, which is stored at low temperature for future use.

Embodiment 2

[0038] A fluid hemostatic glue, comprising a hemostatic effective component and a fluid matrix, the hemostatic effective component includes component A, component B and component C, wherein component A is 0.5g gelatin, and component B is 0.5g α-glycerin Sodium Phosphate, Component C is 0.5g polylysine, the fluid base consists of 10g saline and 0.5mg glycerin. Wherein the jelly strength of gelatin is 200 Bloom / g, and the source of gelatin is pig source.

[0039]Wherein the gelatin of component A is modified gelatin, and the preparation method of the modified gelatin is: weigh 1g of gelatin, dissolve it in 20ml of deionized water, add 0.0125g of EDC and NHS, stir and react at 30°C for 3h, Add ethanol to soak and wash, repeat three times, pre-freeze at -80°C, and freeze-dry using a low-temperature and low-pressure freezer to obtain modified gelatin.

[0040] The preparation method of the fluid hemostatic gel is as follows: Weigh 0.5g of the above-mentioned modified gelatin, 0.5g...

Embodiment 3

[0042] A fluid hemostatic gel, comprising a hemostatic effective component and a fluid matrix, the hemostatic effective component includes component A, component B and component C, wherein component A is 1 g of gelatin, and component B is 0.6 g of β-glycerophosphate Sodium, Component C was 0.6 g polyethyleneimine, and the fluid base consisted of 11 g saline and 2.2 mg sodium lauryl sulfate. Wherein the jelly strength of gelatin is 300 Bloom / g, and the source of gelatin is pig source.

[0043] Wherein the component A gelatin is modified gelatin, the preparation method of the modified gelatin is: weigh 2g of gelatin, dissolve it in 20ml of deionized water, add 0.0250g of EDC and NHS, and stir and react at 25°C for 2.5h , add ethanol to soak and wash, repeat three times, pre-freeze at -80°C, and freeze-dry using a low-temperature and low-pressure freezer to obtain modified gelatin.

[0044] The preparation method of the fluid hemostatic gel is as follows: Weigh 1g of the above-m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a fluid hemostatic glue, a preparation method and application thereof. The fluid hemostatic glue includes a hemostatic effective component and a fluid matrix, and the hemostatic effective component includes component A, component B and component C, wherein component A is gelatin, component B is sodium glycerophosphate, and component C It is polylysine and / or polyethyleneimine, and the mass ratio of component A:component B:component C is (1~6):(1~2):1. The fluid hemostatic gel provided by the present invention can be stored in a fluid state, does not need to be mixed before use, is easy to operate, greatly shortens the operation time, and can quickly form a gel after being applied to the human body. fluidity and hemostatic effect. Furthermore, the present invention can not only increase the strength of the hemostatic glue by modifying and grafting the gelatin, but also significantly increase the adhesion between the hemostatic glue and the wound surface, and further improve the hemostatic effect.

Description

technical field [0001] The invention relates to the field of hemostatic materials, in particular to a fluid hemostatic glue and its preparation method and application. Background technique [0002] For wounds with diffuse bleeding on uneven surfaces or hard-to-reach deep or narrow areas, commonly used sponge or yarn-like hemostatic materials are difficult to achieve sufficient wound coverage, so flowable hemostatic materials are required. The fluid hemostatic material can shape itself according to the shape of the wound to achieve full contact, and has a good effect on the hemostasis of the above-mentioned special wound. [0003] The fluid hemostatic materials currently on the market mainly include Floseal Haemostatic Matrix of Baxter Company and Surgiflo Haemostatic Matrix of Ethicon Company. Among them, Floseal HaemostaticMatrix is ​​a kit for making hemostatic gelatin paste. The gelatin paste was made by first preparing a thrombin solution and then transferring the gela...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/10A61L24/06
CPCA61L24/046A61L24/06A61L24/104A61L2400/04C08L77/04C08L39/02
Inventor 林丽敏邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH