Ocean ecologic toxicology research platform based on microfluidic chip

Abstract

The invention relates to an ocean ecologic toxicology research platform based on a microfluidic chip. The invention provides a microfluidic chemotactic chip. The microfluidic chemotactic chip is formed by the following units: a chip cell culture unit, a chip composite pollution generation unit, a chip pollutant concentration gradient generation unit, a chip control unit and a chip detection system. By integrating various pollutant composite units, the pollutant concentration gradient generation unit, and the array cell culture, cell stress, marking and corresponding detection units on the chip, the multi-index, multi-parameter and multi-response-event analysis for the damage action process of the environmental pollution for the marine organisms can be realized, the toxicity effect of the pollutants can be determined, and a great amount of important toxicology information can be acquired in a single experiment. The ocean ecologic toxicology research platform is significant in functionalcharacteristics in integration and flux compared with the traditional ecologic toxicology toxicity experimental method, and is simple in operation and low in cost; and meanwhile, the platform also has certain universality and can be extensively used for other research fields of the marine environmental sciences.

Description

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AI Technical Summary

Benefits of technology

The technology described by this patented allows for precise monitoring and controllability over different aspects such as liquid levels within chambers or cells during testing processes. It uses tiny valves controlled by an external pump to create pressure gradients inside these chambles. These pressures help with the movement of small particles called bioparticies (biomolecules) from one part into another. By analyzing these data sources, we found that there were many harmful substances like nitrogen oxide, sulfur dioxin, hydrochloramine, methanol, formaldehyde, acroleum residue, etc., which could cause damaging impact upon fish living near them. Additionally, it was discovered that some specific chemical compounds produced when bacteria infected seawater turtled off their shell became volatile after exposure to air containing oxygen at high altitudes.

Problems solved by technology

This patented technology involves integrating different units onto an entire piece of material called a microchip that can be easily analyzed for its ability to cause harm in fishes due to exposure to chemicals such as pesticides during their growth process. By comparing these results against traditional methods like testing them under specific environmental stress scenarios, it becomes possible to identify potential sources of damage from seafood contamination.

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