A kind of preparation technology of concentrated children's Kechuanling oral liquid

A kind of Kechuanling oral liquid and the technology of preparation process, which is applied in the field of preparation technology of innovative specification concentrated children's Kechuanling oral liquid, can solve the problems of large dosage, unsatisfactory taking effect, low effective content, etc. Simple, avoid a large amount of loss, the effect of increasing the content of active ingredients

Active Publication Date: 2020-11-06
HARBIN KANGLONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the problems of low effective content, large dosage and unsatisfactory taking effect of the children's Kechuanling oral liquid in the prior art, and when children and elderly people with dysphagia take the children's Kechuanling oral liquid, in order to achieve the curative effect, it is necessary to take a lot of The problem of a large number of children's cough and asthma oral liquid, the present invention provides a preparation process of innovative specification concentrated type of children's cough and asthma oral liquid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The formula of Xiaoer Kechuanling oral liquid is: 25g of ephedra, 250g of honeysuckle, 125g of bitter almond, 250g of Radix isatidis, 375g of gypsum, 125g of licorice, and 125g of Trichosanthes. The preparation process includes the following steps:

[0037] Add bitter almonds, gypsum, isatis root, licorice, and Trichosanthes, and decoct them with water for 1 hour, then filter; Filter with a 180nm ceramic membrane, control the filtration pressure at 0.3-0.4MPa, and control the temperature at 30-35°C, then add chitosan at a concentration of 0.6g / L, stir evenly, let it stand until it separates, and collect the supernatant , concentrate the supernatant to liquid extract; add ethanol so that ethanol accounts for 65% of the mass fraction of the liquid extract ethanol solution, stir well, and let it stand for refrigeration; take the supernatant, filter, recover ethanol, and concentrate to an appropriate amount , add 2 g of stevioside and 3 g of sodium benzoate, stir evenly, an...

Embodiment 2

[0039] The formula of Xiaoer Kechuanling oral liquid is: 25g of ephedra, 250g of honeysuckle, 125g of bitter almond, 250g of Radix isatidis, 375g of gypsum, 125g of licorice, and 125g of Trichosanthes. The preparation process includes the following steps:

[0040] Add bitter almonds, gypsum, isatis root, licorice, and Trichosanthes, and decoct them with water for 1 hour, then filter; 220nm ceramic membrane for filtration, the filtration pressure is controlled at 0.3-0.4MPa, the temperature is controlled at 30-35°C, and then L-aspartic acid and cationic starch are added according to the concentration of 0.4g / L (L-aspartic acid and The mass ratio of cationic starch is 0.3:1, first add cationic starch, stir for 15 minutes, then add L-aspartic acid), stir evenly, let stand to separate layers, collect the supernatant, and concentrate the supernatant to flow Extract; add ethanol so that the mass fraction of ethanol in the liquid extract ethanol solution is 65%, stir evenly, and let ...

Embodiment 3

[0042] The formula of Xiaoer Kechuanling oral liquid is: 25g of ephedra, 250g of honeysuckle, 125g of bitter almond, 250g of Radix isatidis, 375g of gypsum, 125g of licorice, and 125g of Trichosanthes. The preparation process includes the following steps:

[0043] Add bitter almonds, gypsum, isatis root, licorice, and Trichosanthes, and decoct them with water for 1 hour, then filter; 200nm ceramic membrane for filtration, the filtration pressure is controlled at 0.3-0.4MPa, the temperature is controlled at 30-35°C, and then L-aspartic acid and cationic starch are added according to the concentration of 0.3g / L (L-aspartic acid and The mass ratio of cationic starch is 0.6:1, first add cationic starch, stir for 15 minutes, then add L-aspartic acid), stir evenly, let stand to separate layers, collect the supernatant, and concentrate the supernatant to flow Extract; add ethanol so that the mass fraction of ethanol in the liquid extract ethanol solution is 65%, stir evenly, and let ...

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Abstract

The invention relates to the technical field of preparation technology of a Kechuanling oral solution, in particular to a preparation process of a concentrated type Xiao er Kechuanling oral solution with innovative specifications. The preparation process is simple, and a special flocculant is used to precipitate the solution, thereby eliminating a subsequent filtration step, saving production cost, improving the quality of the oral solution, and avoiding great loss of active ingredients.

Description

technical field [0001] The invention relates to the technical field of preparation technology of Kechuanling oral liquid, in particular to a preparation technology of innovative specification concentrated Kechuanling oral liquid for children. Background technique [0002] Pediatric cough and asthma is a chronic airway inflammatory disease, which is an immune inflammation, characterized by reversible airway narrowing and dyspnea. The clinical manifestations are shortness of breath, cough, expectoration, dyspnea, Wheezing, especially when exhaling, is more pronounced. [0003] Xiaoer Kechuanling Oral Liquid is derived from the traditional prescription "Maxing Shigan Decoction". . Its prescription is composed of 7 traditional Chinese medicines such as ephedra, honeysuckle, bitter almond, isatid root, gypsum, licorice, and Trichosanthes. The current production process mainly uses water extraction and alcohol precipitation. The original drug extract of Xiaoer Kechuanling Oral ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/08A61K47/36A61K47/18A61P11/14A61P11/10A61P11/06A61P11/00A61P31/00
CPCA61K9/0053A61K33/06A61K36/17A61K36/195A61K36/315A61K36/355A61K36/428A61K36/484A61K36/736A61K47/183A61K47/36A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P11/00A61P11/06A61P11/10A61P11/14A61P31/00A61K2300/00
Inventor 穆滨
Owner HARBIN KANGLONG PHARM CO LTD
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