Injectable biologic glue having high-strength adhesion property and preparation method and applications thereof

A glue and biological technology, applied in non-active ingredient medical preparations, applications, drug delivery, etc., can solve the problems of increased operation time and cost, complicated operation, large equipment, etc., and achieves high adhesion ability, easy to use, good quality The effect of biocompatibility

Active Publication Date: 2018-09-14
深圳宁聚生物新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These bioglues have strong adhesion properties and good biocompatibility, but these bioglues are usually two-component bioglues, and double syringes must be used when using them. The equipment is relatively large and the operation is more complicated, especially for Some deep tissue adhesions are more difficult to operate
At the same time, most of these glues are cross-linked by chemical action. If cracking occurs during use, resulting in irreversible damage to chemical bonds, these glues will lose their function, and usually have to be removed and coated with new biological glue, which greatly improves the quality of the glue. Operating time and cost

Method used

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  • Injectable biologic glue having high-strength adhesion property and preparation method and applications thereof
  • Injectable biologic glue having high-strength adhesion property and preparation method and applications thereof
  • Injectable biologic glue having high-strength adhesion property and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take by weighing two arms polyethylene glycol succinimide 5000mg (as shown in formula I, R is formula a, Z is 2, M is an oxygen atom, n value is 56, R 1 , R 2 , R 3 and R 4 are all hydrogen atoms) dissolved in 10mL of pH 7.4 PBS buffer solution (mass-volume concentration is 500mg / ml), weighed 5000mg of tannic acid and dissolved in 10ml pH of 7.4 PBS solution (mass-volume concentration is 500mg / ml), the above two solutions were mixed according to the volume ratio of 1:1 (the mass ratio of two-arm polyethylene glycol succinimide to tannic acid was 1:1), and then centrifuged at a speed of 3000r / min for 5min Finally, pour off the supernatant, and the resulting precipitate is the biological glue of the present invention. Put the bioglue into the syringe and save it for the next step.

[0051] After measurement, the adhesion performance of the bioglue prepared by the present embodiment is 249kPa, which has higher adhesion ability and is far better than commercially avail...

Embodiment 2

[0054] Take by weighing four arms polyethylene glycol succinimide 4000mg (as shown in formula II, R is formula b, Z is 0, M is oxygen atom, n value is 56, R 1 , R 2 , R 3 and R 4 is a hydrogen atom, R 5 , R 6 , R 7 and R 8 Both are hydroxyl groups) dissolved in 10mL of PBS buffer solution with pH 7.4 (mass-volume concentration is 400mg / ml), weighed 4000mg of tannic acid and dissolved in 10ml of PBS solution with pH 7.4 (mass-volume concentration is 400mg / ml ml), the above two solutions were mixed according to the volume ratio of 2:1 (the mass ratio of four-arm polyethylene glycol succinimide to tannic acid was 2:1), and centrifuged at a speed of 3000r / min for 5min , pour off the supernatant, and the resulting precipitate is the biological glue of the present invention. Put the bioglue into the syringe and save it for the next step.

[0055] It is measured that the adhesion property of the bioglue prepared in this embodiment is 265kPa, which has a higher adhesion abilit...

Embodiment 3

[0058] Take by weighing six arm polyethylene glycol succinimide 4000mg (as shown in formula III, R is formula a, Z is 3, M is nitrogen atom, n value is 28, R 1 , R 2 , R 3 and R 4 are hydrogen atoms, R 5 , R 6 , R 7 and R 8 Both are methyl, R 9 , R 10 , R 11 and R 12 Both are benzene rings) dissolved in 10mL of PBS buffer solution with pH 7.4 (mass-volume concentration is 400mg / ml), weighed 4000mg of tannic acid and dissolved in 10ml of PBS solution with pH 7.4 (mass-volume concentration is 400mg / ml ml), the above two solutions were mixed according to the volume ratio of 1:4 (the mass ratio of six-arm polyethylene glycol succinimide to tannic acid was 1:4), and centrifuged at a speed of 3000r / min for 5min , pour off the supernatant, and the resulting precipitate is the biological glue of the present invention. Put the bioglue into the syringe and save it for the next step.

[0059] It is measured that the adhesive property of the bioglue prepared in this embodiment...

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Abstract

The invention discloses an injectable biologic glue having a high-strength adhesion property and a preparation method and applications thereof. The injectable biologic glue is formed by the hydrogen bond interaction of a polyethylene glycol derivative (polyethylene glycol succinimide ester) and tannic acid. The preparation method of the injectable biologic glue includes (1) preparing a solution 1of the polyethylene glycol derivative; (2) preparing a solution 2 of the tannic acid; and (3) mixing the solution 1 and the solution 2 to obtain a sediment through centrifugation. The injectable biologic glue has potential applications in the following fields: surgical wound adhesion; drug delivery and release systems; medical implants; and surface coatings of medical implants; The beneficial effects of the injectable biologic glue are that the injectable biologic glue can be formed by the interaction of two substances which are the PEG derivative and the tannic acid through a physical effect(the hydrogen bond); the injectable biologic glue has high adhesion capability; and the injectable biologic glue can be used by single-tube injectors so that the usage is more convenient.

Description

technical field [0001] The invention relates to a biological glue, in particular to an injectable biological glue with high adhesion performance. Background technique [0002] Surgical wound suturing problem has been paid more and more attention by people. The traditional way generally uses sutures. However, suturing will introduce new suture wounds, which will cause secondary damage to the wound during the stitch removal process, and sutures are prone to infection. [0003] So now people have developed biological glue to replace sutures in surgery. Bio-glues are generally divided into two categories: natural and synthetic bio-glues. Among them, natural bioglue is represented by fibrin glue, which is usually weak in strength and prone to cross-infection problems such as blood diseases such as AIDS. Synthetic glue is mainly based on derivatives of cyanoacrylate, which has high strength, but poor biocompatibility, and the degradation products are toxic. [0004] People ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00
CPCA61K47/34A61L24/001A61L24/046A61L2400/06C08L79/08
Inventor 吴德成补亚忠杨飞
Owner 深圳宁聚生物新材料科技有限公司
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