Injectable biologic glue having high-strength adhesion property and preparation method and applications thereof
A glue and biological technology, applied in non-active ingredient medical preparations, applications, drug delivery, etc., can solve the problems of increased operation time and cost, complicated operation, large equipment, etc., and achieves high adhesion ability, easy to use, good quality The effect of biocompatibility
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Embodiment 1
[0050] Take by weighing two arms polyethylene glycol succinimide 5000mg (as shown in formula I, R is formula a, Z is 2, M is an oxygen atom, n value is 56, R 1 , R 2 , R 3 and R 4 are all hydrogen atoms) dissolved in 10mL of pH 7.4 PBS buffer solution (mass-volume concentration is 500mg / ml), weighed 5000mg of tannic acid and dissolved in 10ml pH of 7.4 PBS solution (mass-volume concentration is 500mg / ml), the above two solutions were mixed according to the volume ratio of 1:1 (the mass ratio of two-arm polyethylene glycol succinimide to tannic acid was 1:1), and then centrifuged at a speed of 3000r / min for 5min Finally, pour off the supernatant, and the resulting precipitate is the biological glue of the present invention. Put the bioglue into the syringe and save it for the next step.
[0051] After measurement, the adhesion performance of the bioglue prepared by the present embodiment is 249kPa, which has higher adhesion ability and is far better than commercially avail...
Embodiment 2
[0054] Take by weighing four arms polyethylene glycol succinimide 4000mg (as shown in formula II, R is formula b, Z is 0, M is oxygen atom, n value is 56, R 1 , R 2 , R 3 and R 4 is a hydrogen atom, R 5 , R 6 , R 7 and R 8 Both are hydroxyl groups) dissolved in 10mL of PBS buffer solution with pH 7.4 (mass-volume concentration is 400mg / ml), weighed 4000mg of tannic acid and dissolved in 10ml of PBS solution with pH 7.4 (mass-volume concentration is 400mg / ml ml), the above two solutions were mixed according to the volume ratio of 2:1 (the mass ratio of four-arm polyethylene glycol succinimide to tannic acid was 2:1), and centrifuged at a speed of 3000r / min for 5min , pour off the supernatant, and the resulting precipitate is the biological glue of the present invention. Put the bioglue into the syringe and save it for the next step.
[0055] It is measured that the adhesion property of the bioglue prepared in this embodiment is 265kPa, which has a higher adhesion abilit...
Embodiment 3
[0058] Take by weighing six arm polyethylene glycol succinimide 4000mg (as shown in formula III, R is formula a, Z is 3, M is nitrogen atom, n value is 28, R 1 , R 2 , R 3 and R 4 are hydrogen atoms, R 5 , R 6 , R 7 and R 8 Both are methyl, R 9 , R 10 , R 11 and R 12 Both are benzene rings) dissolved in 10mL of PBS buffer solution with pH 7.4 (mass-volume concentration is 400mg / ml), weighed 4000mg of tannic acid and dissolved in 10ml of PBS solution with pH 7.4 (mass-volume concentration is 400mg / ml ml), the above two solutions were mixed according to the volume ratio of 1:4 (the mass ratio of six-arm polyethylene glycol succinimide to tannic acid was 1:4), and centrifuged at a speed of 3000r / min for 5min , pour off the supernatant, and the resulting precipitate is the biological glue of the present invention. Put the bioglue into the syringe and save it for the next step.
[0059] It is measured that the adhesive property of the bioglue prepared in this embodiment...
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