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Application of inula flower atractylenolide in preparation of drugs for reducing taxol neurotoxicity

A technique of neurotoxicity, inula, used in the field of medicine

Inactive Publication Date: 2018-09-21
侯桓光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no nootrope ketone A, nootrope ketone B, inulalide, oxo-inulalide, cyclic ether inulalide, and anolide A report on reducing the neurotoxicity of paclitaxel with chrysanthemum lactone B

Method used

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  • Application of inula flower atractylenolide in preparation of drugs for reducing taxol neurotoxicity
  • Application of inula flower atractylenolide in preparation of drugs for reducing taxol neurotoxicity
  • Application of inula flower atractylenolide in preparation of drugs for reducing taxol neurotoxicity

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Embodiment Construction

[0032] The following describes the substantive content of the present invention in detail in conjunction with the drawings and embodiments, but does not limit the protection scope of the present invention.

[0033] 1. Experimental materials

[0034] Nootropic terpene A, nootropic terpene B, inula lactone, oxo inulalide, cyclic ether inulalide, inula lactone A, inula lactone Lactone B and paclitaxel are self-made or purchased, with a purity of ≥95%, and the chemical structure is as follows figure 1 shown. Nrf2 antibody was purchased from abcam company.

[0035] SPF-grade male SD rats, weighing 190-210 g, were purchased from Qinglongshan Animal Breeding Farm in Jiangning, Nanjing, and were reared routinely.

[0036] 2. Experimental method

[0037] 1. Grouping, modeling and administration

[0038] SD rats were randomly divided into normal group, model group and each drug group, 10 in each group. The model group and each drug group were intraperitoneally injected with paclit...

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Abstract

The invention discloses application of inula flower atractylenolide in preparation of drugs for reducing taxol neurotoxicity. It discovers that alpinia oxyphylla arborinone A, alpinia oxyphylla arborinone B, inula flower atractylenolide, oxo big flower inulicin, cyclic ether big flower inulicin, chloranthus spicatus lactone A and chloranthus spicatus lactone B can remarkably reduce taxol neurotoxicity, and can be developed into taxol chemotherapy auxiliary drugs to reduce injury of taxol to a surrounding nervous system.

Description

technical field [0001] The present invention belongs to the field of medicine, and specifically relates to nootrope ketone A, nootrope ketone B, inula lactone, oxo inula lactone, cyclic ether inula lactone, The application of chrysanthemum lactone A and chrysanthemum lactone B in the preparation of drugs for reducing the neurotoxicity of paclitaxel. Background technique [0002] Taxol (Paclitaxel, trade name Taxol) is a diterpenoid compound extracted from the Taxus genus of Taxaceae, with a molecular formula of C47H51NO14. In 1963, American chemists Varney and Wall from a species that grew in the large forests of the western United States The crude extract of paclitaxel was isolated from the bark and wood of Pacific fir, and it was found to have strong anti-tumor activity in screening experiments. In 1971, the monomeric component of paclitaxel was isolated, its chemical structure was determined, and it was officially named paclitaxel. From 1989 to 1990, after completing th...

Claims

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Application Information

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IPC IPC(8): C07C49/733C07D307/77C07D307/93C07D493/04C07D493/10A61K31/365A61K31/122A61K31/337A61P39/02A61P35/00
CPCC07C49/733A61K31/122A61K31/337A61K31/365A61P35/00A61P39/02C07D307/77C07D307/93C07D493/04C07D493/10A61K2300/00
Inventor 张学珍
Owner 侯桓光