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Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies

An ultrasound therapy, ultrasound technology, applied in the field of ultrasound systems, can solve the problems of disappearance, no effective contribution to the treatment effect, etc.

Active Publication Date: 2018-09-28
KONINKLJIJKE PHILIPS NV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, VAR will be efficient at the beam peak in order to achieve sufficient acoustic beam pressure, but the VAR will fade away near the beam
The disappearance of VAR away from the center of the beam zone occurs at lower ultrasound amplitudes, which does not effectively contribute to the therapeutic effect

Method used

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  • Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies
  • Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies
  • Interleaved beam pattern for sonothrombolysis and other vascular acoustic resonator mediated therapies

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Embodiment Construction

[0023]In accordance with the principles of the present disclosure, ultrasonic thrombolysis systems and methods are described that more effectively use a vascular acoustic resonator VAR at the site of a blood clot by interleaving therapeutic beam scanning. The ultrasonic thrombolysis system includes: at least one ultrasonic array (e.g., a phased array) arranged to transmit ultrasonic therapeutic beams to a region of interest; and a transmission controller coupled to the array and arranged to A sequence of patterns controls the steering of the treatment beam, wherein each temporally subsequent pattern includes beam zones spatially interleaved between beam zones of a previous pattern.

[0024] The limited overlap between the beam regions of subsequent patterns reduces the instantaneous acoustic power at the skin surface while providing sufficient acoustic power to destroy the VAR at the desired location below the surface. Subsequent scans with a different beam pattern can then ef...

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Abstract

A therapeutic ultrasound system transmits a staggered or interleaved pattern of therapy beams for use in sonothrombolysis and other Vascular Acoustic Resonators (VAR) mediated therapy. The inventive technique minimizes VAR, e.g. microbubble, destruction due to adjacent beams, ensures uniform sonication of the targeted region by filling in the spaces between the beams in subsequent passes, and further provides a means for bubble replenishment to maximize the clot lysis from ultrasound. The technique is also applicable to diagnostic ultrasound, VAR mediated drug delivery and blood brain barrieropening.

Description

technical field [0001] The present disclosure relates to medical ultrasound systems, and in particular to ultrasound systems in combination with vascular acoustic resonators (VARs) (eg, gas-filled microbubbles) to perform ultrasonic thrombolysis and other treatments. Background technique [0002] Ischemic stroke is one of the most debilitating diseases known in medicine. Blocked or significantly reduced blood flow to the brain can quickly lead to paralysis or death. Attempts to achieve recanalization by thrombolytic drug therapy (eg, treatment with tissue plasminogen activator (tPA)) have been reported to result in symptomatic intracerebral hemorrhage in many cases. Advances in the diagnosis and management of this serious health-damaging effect are the subject of continuing medical research. [0003] US Patent 8211023 (Swan et al.) describes a diagnostic ultrasound system and method that enables a clinician to transcranially visualize areas of cerebral vessels where blood ...

Claims

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Application Information

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IPC IPC(8): A61N7/02A61B17/22A61N7/00
CPCA61N7/02A61B17/22004A61B2017/22008A61N2007/0039A61N2007/0078A61N2007/0082A61N2007/0095A61N2007/027A61B8/488A61B8/06A61B8/14A61B2017/00106A61B2017/22028
Inventor S·W·迪亚尼斯J·E·鲍尔斯R·塞普W·T·史Y·博伦E·J-M·高德J-M·P·R·许韦林
Owner KONINKLJIJKE PHILIPS NV
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