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A highly efficient anti-cancer and anti-oxidation complex liposome

A complex lipid and anti-oxidation technology, which is applied in liposome delivery, anti-toxic agent, drug combination, etc., can solve the problems of single function of β-carotene liposome, poor stability and easy oxidation of coix seed oil liposome, etc. Achieve the effect of improving anti-cancer effect, improving preparation technology and improving immunity

Active Publication Date: 2020-11-17
JIANGXI SCI & TECH NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Another technical problem to be solved by the present invention is that the existing coix seed oil liposomes have poor stability and are easily oxidized, and the stability needs to be improved.
[0007] Another technical problem to be solved by the present invention is that the existing β-carotene liposome has single function and unsatisfactory anticancer effect

Method used

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  • A highly efficient anti-cancer and anti-oxidation complex liposome
  • A highly efficient anti-cancer and anti-oxidation complex liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 140mg of lecithin, 20mg of cholesterol, and 6mg of Coix Seed Oil in 10mL of ethanol, take 0.6mL of β-carotene-dichloromethane solution (1mg / mL) and add it to the above ethanol solution and mix well to obtain an oil phase. Slowly inject into 25mL of 20mM / L, pH 6.8 phosphate buffer solution (at a constant temperature of 43°C and in the state of magnetic stirring). After the addition is complete, control the temperature and rotation speed to remain constant, continue to stir for 20min, and then transfer the sample to a water bath shaker , shake at 100 r / min at 45°C for 20 minutes to obtain a liposome coarse emulsion; after shaking, transfer the sample to a rotary evaporator, and distill ethanol and dichloromethane under vacuum at 45°C to obtain complex liposomes.

Embodiment 2

[0028] Weigh 560mg of lecithin, 80mg of cholesterol and 24mg of coix seed oil in 40mL of ethanol, take 2.4mL of β-carotene-dichloromethane solution (1mg / mL) and add it to the above ethanol solution and mix well to obtain an oil phase. Slowly inject into 100mL of 20mM / L, pH 6.8 phosphate buffer solution (at a constant temperature of 43°C and in a state of magnetic stirring). After the addition is complete, control the temperature and rotation speed to remain constant, continue to stir for 20min, and then transfer the sample to a water bath shaker , shake at 100 r / min at 45°C for 20 minutes to obtain a liposome coarse emulsion; after shaking, transfer the sample to a rotary evaporator, and distill ethanol and dichloromethane under vacuum at 45°C to obtain complex liposomes.

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Abstract

The invention belongs to the technical fields of health-care food and medicine products, and provides high-efficiency anti-cancer anti-oxidation composite lipidosome and a preparation method thereof.The composite lipidosome mainly comprises the following raw materials: egg yolk lecithin, coix seed oil, beta-carotene, cholesterol, disodium hydrogen phosphate and sodium dihydrogen phosphate. The composite lipidosome prepared by the method has high antioxidation activity and anti-cancer effect. Relative to the conventional coix seed oil lipidosome and the beta-carotene lipidosome, the high-efficiency anti-cancer anti-oxidation composite lipidosome obviously improves anti-oxidation activity and anti-cancer activity. The composite lipidosome is simple in preparation process and low in cost andhas good application prospect.

Description

technical field [0001] The invention relates to the fields of health food and medicine, in particular to a composite liposome containing coix seed oil and β-carotene as two active ingredients, and the composite liposome has a simple preparation process and has good anticancer and anticancer properties. Oxidation activity. Background technique [0002] Coix seed oil, as a medicinal and edible functional oil, has broad-spectrum anticancer activity, especially for liver cancer, nasopharyngeal cancer, breast cancer, and esophageal cancer. However, coix seed oil has poor water solubility and low bioavailability; the unsaturated fatty acid content in the components exceeds 70%, which is easy to oxidize and decompose to produce harmful substances, which not only affects its efficacy, but also is harmful to health. Its clinical application is subject to certain restrictions. Therefore, adding a certain amount of fat-soluble antioxidant protective agent and changing the physical sta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K31/015
CPCA23L33/10A23L33/105A23L33/115A23V2002/00A61K9/127A61K9/1277A61K31/015A61K36/8994A61K47/28A61P35/00A61P39/06A61K2300/00A23V2200/30A23V2200/308A23V2250/18A23V2250/211
Inventor 白春清刘华郑景霞赵利袁美兰江勇陈丽丽
Owner JIANGXI SCI & TECH NORMAL UNIV
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