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Soft capsule containing lubiprostone as well as preparation method thereof

A lubiprostone and soft capsule technology, applied in the field of drug preparation, can solve problems such as uneven bioavailability of lubiprostone, improve stability and bioavailability, reduce degradation, and bioavailability high effect

Inactive Publication Date: 2018-10-09
青海制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology improves on existing methods for making certain types of drugs that have low solubility or poor absorption into bloodstream tissues such as oxypropylene (oxytropin). By reducing its decomposition overcomes this issue, it becomes more effective at delivering these medications through systemic circulatory systems without causing side-effects like other treatments. Additionally, while some forms require specialized equipment, there exist liquid formulations containing only one ingredient, which makes them easier to manufacture than traditional powders used during production processes. Overall, this new process provides better quality products for patients who may benefit from their treatment due to enhanced pharmacokinetic properties compared to current dosage regimes.

Problems solved by technology

This patented technical solution described in this patents relates to improving the effectiveness of drugs called lupus necrosis factor receptor activation modulators (LNGFRM), particularly those used alone but also combined together like other medicines. LNP-37 is one example where these two compounds may work synergistically when given individually at different levels. However, there exist challenges related to achieving consistently high drug absorption rates from solid dosages while maintaining good taste sensitivity and reduced side effects associated with administering multiple agents simultanously.

Method used

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  • Soft capsule containing lubiprostone as well as preparation method thereof
  • Soft capsule containing lubiprostone as well as preparation method thereof
  • Soft capsule containing lubiprostone as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A preparation method of soft capsules containing lubiprostone, carried out as follows:

[0027] a. Take the raw materials of the soft capsule shell according to the proportion, heat them in the glue tank, mix them evenly, remove the bubbles under vacuum, take samples to measure the moisture and viscosity, and keep them warm at 50-70°C for later use after passing the inspection;

[0028] b. Heat and stir the solvent in a water bath at 70-80°C to form a uniform solution, cool to room temperature, add the main ingredient to dissolve completely, and set aside;

[0029] c. Determine the loading amount of the content according to the main drug content;

[0030] d. prepare soft capsules by compression method;

[0031] e. the prepared soft capsules are placed in a rotating drier for drying, and the oil stains on the surface are washed away with 95% ethanol, and then the soft capsules are dried in a drying room;

[0032] f. dry soft capsules are inspected and packaged.

[003...

Embodiment 2

[0040] A preparation method of soft capsules containing lubiprostone, carried out as follows:

[0041] a. Take the raw materials of the soft capsule shell according to the proportion, heat them in the glue tank, mix them evenly, remove the bubbles under vacuum, take samples to measure the moisture and viscosity, and keep them warm at 50-70°C for later use after passing the inspection;

[0042] b. Heat and stir the solvent in a water bath at 70-80°C to form a uniform solution, cool to room temperature, add the main ingredient to dissolve completely, and set aside;

[0043] c. Determine the loading amount of the content according to the main drug content;

[0044] d. prepare soft capsules by compression method;

[0045] e. the prepared soft capsules are placed in a rotating drier for drying, and the oil stains on the surface are washed away with 95% ethanol, and then the soft capsules are dried in a drying room;

[0046] f. dry soft capsules are inspected and packaged.

[004...

Embodiment 3

[0055] A preparation method of soft capsules containing lubiprostone, carried out as follows:

[0056] a. Take the raw materials of the soft capsule shell according to the proportion, heat them in the glue tank, mix them evenly, remove the bubbles in vacuum, take samples to measure the moisture and viscosity, and keep them warm at 50-70°C for later use after passing the inspection;

[0057] b. Heat and stir the solvent in a water bath at 70-80°C to form a uniform solution, cool to room temperature, add the main ingredient to dissolve completely, and set aside;

[0058] c. Determine the loading amount of the content according to the main drug content;

[0059] d. prepare soft capsules by compression method;

[0060] e. the prepared soft capsules are placed in a rotating drier for drying, and the oil stains on the surface are washed away with 95% ethanol, and then the soft capsules are dried in a drying room;

[0061] f. dry soft capsules are inspected and packaged.

[0062] ...

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Abstract

The invention discloses a soft capsule containing lubiprostone as well as a preparation method thereof. The capsule is a soft elastic capsule and consists of a capsule shell and a liquid composition accommodated in the capsule shell; the liquid composition comprises lubiprostone, a proper solvent and the like; and the capsule shell comprises the following components: gelatin, purified water, a plasticizer, a preservative, an antioxidant, an opacifying agent and a coloring agent. The soft capsule is short in disintegration time, rapid in dissolution, high in bioavailability, accurate in dosageand easy to absorb. The soft capsule containing the lubiprostone can effectively improve the stability and the bioavailability of the lubiprostone active component; and the preparation method is relatively simple and easy to produce, and has wide application prospect.

Description

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Claims

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Application Information

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Owner 青海制药有限公司
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