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Dipeptide el for improving insulin resistance and use thereof

A technology for insulin resistance and hypoglycemia, applied in the field of dipeptide EL, to achieve the effect of promoting synthesis

Inactive Publication Date: 2020-09-01
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the currently reported hypoglycemic polypeptides are proteolytic mixtures, and seldom involve specific single polypeptides to achieve hypoglycemic effects from improving insulin resistance.

Method used

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  • Dipeptide el for improving insulin resistance and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1) The hypoglycemic activity of dipeptide EL at a concentration of 1.0 mg / mL:

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PUM

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Abstract

The invention discloses dipeptide EL to improve insulin resistance. An amino acid sequence of the dipeptide EL is Glu-Leu. The invention also discloses application of the dipeptide EL in the preparation of hypoglycemic drugs; the dipeptide EL is suitable for the preparation of hypoglycemic drugs to improve insulin resistance, namely the preparation of drugs that may significantly promote glucose consumption of insulin resistant HepG2 cells and glycogen synthesis, improve insulin resistance, and arrive at glucose reduction.

Description

Technical field [0001] The present invention belongs to the field of biotechnology, and in particular relates to dipeptide EL with the function of lowering blood sugar and its use. Background technique [0002] Diabetes is a common and frequently-occurring disease that seriously endangers human health. According to the latest report of the International Diabetes Federation (IDF), there were 425 million people with diabetes worldwide in 2017, and it is estimated that by 2045, there will be 629 million people with diabetes. my country has the largest number of diabetic patients, with 134.3 million patients and a prevalence rate of 10.9%. Among them, type 2 diabetes accounts for 90%-95% of diabetes. At present, its treatment is still based on drug therapy, mainly including acarbose, voglibose, repaglinide, nateglinide, and glimepe Urea, metformin, thiazolidinediones, etc., although these drugs can control blood sugar well, they are prone to drug resistance after long-term use, acc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K5/072A61K38/05A61P5/50A61P3/10
CPCA61K38/00A61P3/10A61P5/50C07K5/06104
Inventor 朱作艺王伟张玉李雪王君虹
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES