Preparation method of milbemycin oxime

Abstract

The invention discloses a preparation method of milbemycin oxime. The preparation method comprises the following steps: taking an ethyl acetate-ethanol solution as a reaction solvent to dissolve milbemycin ketone, and adding and a water solution of hydroxylamine hydrochloride for carrying out a reaction for 4-6 hours to prepare the milbemycin oxime. The preparation method also comprises the stepsof purifying the prepared milbemycin oxime, and the specific purifying steps are as the follows: washing the prepared milbemycin oxime with water, dissolving the washed milbemycin oxime with ethanol,dropwise adding the obtained solution into water for crystallization under stirring, and carrying out filtering and drying to obtain the pure product of milbemycin oxime. Compared with the prior art,the preparation method can be used to greatly reduce the occupational health hazard of employees by using the low-toxicity solvent instead of a high-toxicity solvent. The reaction time is greatly shortened, and the production efficiency is improved.

Description

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AI Technical Summary

Benefits of technology

This technology allows for better conversion between different chemicals from one type of molecule called mimicry alcohol (MA) or diketonate ester (DK). By doing this it produces an improved amount of product with high yields compared to previous methods like dichloromethanesulfonium bromide/dioxydehydesorbornyl chloroformamine. Additionally, there're less harmful side reactions caused when converting MA or DK through these processes.

Problems solved by technology

The technical problem addressed in this patented method involves finding ways to make it safer for workers who work at chemical plants or other facilities that use these drugs due to their high safety concerns associated therewith.