Application of tremella polysaccharides in preparation of medicines for preventing and controlling obesity

A tremella polysaccharide and drug technology, applied in the field of biomedicine, to prevent fat cell hypertrophy, improve tolerance, and inhibit fat cell hypertrophy

Inactive Publication Date: 2018-10-16
TSINGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes how certain specific types of bacteria called gram-negative rods are used during different stages of food production or processing (such as fermentation). These microorganisms help break down fats from ingredients like milk into smaller molecules by breaking them up more easily when they come through water), which helps keep it healthy without losing its nutrients. Additionally, these tiny particles made with this type of material also slow down the process of absorbing sugar from other sugars found inside our body cells. Overall, this technology allows us to make medicine that prevents excessive buildup on your stomachs while still having some benefits such as reducing calorie intake and improving metabolism.

Problems solved by technology

The technical problem addressed in this patents relates to finding ways to safely treat or manage overweight conditions without causing harmful side effects on patients who may be at risk for heart failure (HF).

Method used

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  • Application of tremella polysaccharides in preparation of medicines for preventing and controlling obesity
  • Application of tremella polysaccharides in preparation of medicines for preventing and controlling obesity
  • Application of tremella polysaccharides in preparation of medicines for preventing and controlling obesity

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preparation example Construction

[0026] The present invention has no special limitation on the preparation method of the tremella polysaccharide, and the conventional preparation method of the tremella polysaccharide can be adopted by those skilled in the art, such as conventional hot water extraction method, alcohol extraction method, alkali extraction method and enzymatic hydrolysis The formulation is extracted from tremella.

[0027] In the present invention, the drugs preferably include drugs for preventing and treating lipid accumulation in liver tissue. In the present invention, the content of tremella polysaccharide in the medicine is preferably 50-60%; the method of taking the medicine is preferably oral, and the recommended daily dose of the tremella polysaccharide is 16-32 mg / kg. The number of polysaccharides taken per day is preferably 1 to 2 times. When taking once a day, the present invention has no special limitation on the time of taking; when taking twice a day, it is preferably taken once in...

Embodiment 1

[0033] Pharmacodynamic study of tremella polysaccharides in improving obesity and related metabolic diseases

[0034] 1. Experimental method

[0035] 1. Design of animal experiments

[0036] The C57BL / 6 mice were fed in the Animal Center of Tsinghua University in a 12-hour light-dark environment, with a temperature of 23±3°C and a relative humidity of 50%. After 1 week of adaptive feeding, the mice were randomly divided into 5 groups (n=10), and the group design was as follows: normal control group (ND), fed normal diet; high-fat control group (HFD), low-dose diet Tremella polysaccharide group (TP-L), dietary medium-dose tremella polysaccharide group (TP-M), dietary high-dose tremella polysaccharide group (TP-H), fed high-fat diet. Low, medium and high doses of tremella polysaccharide extract were 100mg / kg, 200mg / kg, 400mg / kg, orally administered for 14 weeks, ND and HFD groups were given intragastric water; weighed once every 7 days, and the mice were free to eat and drink ...

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Abstract

The invention provides application of tremella polysaccharides in preparation of medicines for preventing and controlling obesity, and belongs to the field of biomedicines. The tremella polysaccharides can be used for preventing the accumulation of liver tissue lipid and the adipocyte hypertrophy, and further preventing and controlling the obesity, can improve the tolerance of glucose and insulin,and reach the function of reducing blood lipid, cholesterol and lipid deposition.

Description

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Claims

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Application Information

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Owner TSINGHUA UNIV
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