Application of [7-(2,2-dimethylbut-3-enamido)-2,4-dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f] quinolin-1-yl acetate, DQA] in preparation of lipid-lowering drugs

A kind of technology of octahydrobenzquinoline acetate and crotonamide group, which is applied in the application field of monomer compounds to achieve the effect of reducing body weight

Active Publication Date: 2021-11-16
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant research report on the use of 7-(2,2-dimethyl-3-butenamido)-octahydrobenzoquinoline acetate in lipid-lowering drugs

Method used

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  • Application of [7-(2,2-dimethylbut-3-enamido)-2,4-dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f] quinolin-1-yl acetate, DQA] in preparation of lipid-lowering drugs
  • Application of [7-(2,2-dimethylbut-3-enamido)-2,4-dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f] quinolin-1-yl acetate, DQA] in preparation of lipid-lowering drugs
  • Application of [7-(2,2-dimethylbut-3-enamido)-2,4-dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f] quinolin-1-yl acetate, DQA] in preparation of lipid-lowering drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: 7-(2,2-dimethyl-3-butenamido)-octahydroquinoline acetate, namely 7-(2,2-dimethyl-3-butenamido )-2,4-Dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]-1-quinolyl-acetate on 3T3 - Lipid-lowering activity experiment of L1 adipocytes.

[0014] Reagents and Drugs:

[0015] Adipocytes (3T3-L1, ATCC, Rockville, MD, USA) can store excess energy in the form of triglycerides, maintain a high differentiation ability, and can be induced to differentiate into mature adipocytes, which is an internationally recognized research Cellular model of lipid metabolism; Simvastatin (Sim), purchased from Sigma Aldrich Company (St. Louis, MO, USA), >99.5% pure (HPLC); DQA, 7-(2,2-dimethyl -3-butenamido)-octahydroquinoline acetate, which is extracted and isolated from the aerial root endophyte of the medicinal plant Lavender in the laboratory, with a purity of >98% (HPLC).

[0016] Experimental method and results:

[0017] 1. 3T3-L1 Adipocyte Differentiation and Administration ...

Embodiment 2

[0022] Example 2: 7-(2,2-dimethyl-3-butenamido)-octahydroquinoline acetate, namely 7-(2,2-dimethyl-3-butenamido )-2,4-Dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]-1-quinolyl-acetate for acute Lipid accumulation and hypolipidemic experiment in high-fat-induced obese mice.

[0023] Reagents and Drugs:

[0024] 4-week-old male C57BL / 6 mice (Hunan Slack Jingda Experimental Animal Co., Ltd.); Simvastatin (Sim), purchased from Sigma Aldrich Company (St. Louis, MO, USA), with a purity of >99.5% (HPLC ); DQA, that is, 7-(2,2-dimethyl-3-butenamido)-octahydroquinoline acetate, was extracted and isolated from the aerial root endophyte of the medicinal plant Lavender by the laboratory Obtained with >98% purity (HPLC).

[0025] Experimental method and results:

[0026] 1. Establishment of acute hyperlipidemia-induced obesity animal model

[0027] Male C57BL / 6 mice aged 4 weeks were used for modeling. After feeding the purchased mice with a normal diet in the laboratory for one...

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Abstract

The invention belongs to the technical field of application of monomeric compounds, and particularly relates to application of [7-(2,2-dimethylbut-3-enamido)-2,4-dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f] quinolin-1-yl acetate, DQA] in preparation of drugs for lowering lipid and treating obesity. In-vitro and in-vivo lipid-lowering experimental model research finds that the [7-(2,2-dimethylbut-3-enamido)-2,4-dimethyl-5-oxo-1,2,3,4,4a,5,6,10b-octahydrobenzo[f] quinolin-1-yl acetate, DQA] has the activity of reducing fat accumulation and lowering blood fat, can be used for preparing drugs for lowering lipid and treating obesity, is suitable for large-scale popularization and has potential application value.

Description

technical field [0001] The invention belongs to the technical field of application of monomer compounds, and in particular relates to the application of 7-(2,2-dimethyl-3-butenamido)-octahydroquinoline acetate in the preparation of lipid-lowering drugs . Background technique [0002] Hyperlipidemia is one of the common metabolic diseases in my country, and its incidence is increasing year by year. It can cause a series of cardiovascular and cerebrovascular complications, seriously affecting the quality of life and average life expectancy of the population in our country. Obesity is one of the main manifestations. It is estimated that by 2050, global obesity will become an epidemic trend. Obesity in adult males will rise to 65%, adult female obesity will rise to 50%, and underage children will rise to to about 25%. Survey data show that hyperlipidemia is an important factor in the induction of coronary heart disease, myocardial infarction, cerebral thrombosis, and stroke. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/473A61P3/04A61P3/06
CPCA61K31/473A61P3/04A61P3/06
Inventor 玉万国唐皎瑢陈春华
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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