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Anti-inflammation compounds and preparation method thereof

A compound and anti-inflammatory spirit technology, applied in the field of anti-inflammatory spirit compounds and their preparation, can solve problems such as side effects, and achieve the effects of reliable side effects, rapid recovery, and good anti-inflammatory effects

Active Publication Date: 2018-10-19
苏州埃莫尔医药科技有限公司
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  • Abstract
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Problems solved by technology

Currently the most used drugs include steroids and non-steroidal anti-inflammatory drugs, but there are side effects and drug resistance in one way or another

Method used

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  • Anti-inflammation compounds and preparation method thereof
  • Anti-inflammation compounds and preparation method thereof
  • Anti-inflammation compounds and preparation method thereof

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Embodiment Construction

[0033] The following clearly and completely describes the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0034] In the embodiment of the present invention, an anti-inflammatory spirit compound and its preparation method, the general structural formula is: cFLFLFX 1 x 2 ,

[0035] where cFLFLF is myristoyl-phenylalanyl-(D)leucyl-phenylalanyl-(D)leucyl-phenylalanyl- or cinnamoyl-phenylalanyl-(D)leucine Acyl-phenylalanyl-(D)leucyl-phenylalanine;

[0036] When X 1 :-O-,X 2 : Glutathione, gallic acid or 6-aminoascorbic acid, where glutathione is abbreviated as -GLT, gallic acid is abbreviated as (D)-GA, and 6-aminoascorbic acid is abbr...

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Abstract

The invention discloses anti-inflammation compounds and a preparation method thereof. The structural formula of the anti-inflammation compounds is cFLFFX1X2, which is tetradecanoyl-phenylalanyl-(D)-lencyl-phenylalanyl-(D)-lencyl-phenylalanyl- or cinnamoyl-phenylalanyl-(D)-lencyl-phenylalanyl-(D)-lencyl-phenylalanine. The antagonist compounds are targeting formyl peptide receptors and have an anti-inflammation effect. The compounds are composed of two parts: a formyl peptide receptor targeting small molecule peptide and an anti-oxidation group and are used to treat bacterium-free inflammation or bacterial inflammation in clinic. Through the formyl peptide receptor, the leukocyte activation time, process and degree can be regulated and controlled directly, thus the whole treatment process has the advantages that the spectrum is wider, the treatment is more reliable, and the side effect is weaker; the patients can be recovered more quickly; the inflammation can be removed more quickly; and at the same time, the patients do not need to eat steroid anti-inflammation drugs or non-steroid anti-inflammation drugs and do not need to worry about side effects and drug resistance.

Description

technical field [0001] The invention relates to a compound, in particular to an anti-inflammatory spiritual compound and a preparation method thereof. Background technique [0002] At present, excessive activation of leukocytes and pathological inflammation are the pathological causes of various acute and chronic diseases, and precise regulation of the activation time, process, and degree of immune leukocytes is the key to control and treatment. Clinically, there is no broad-spectrum, reliable, and less side-effect method to regulate the activity of immune leukocytes. Currently the most used drugs include steroids and non-steroidal anti-inflammatory drugs, but all of them have side effects and drug resistance in one way or another. Contents of the invention [0003] The object of the present invention is to provide an anti-inflammatory spiritual compound and its preparation method to solve the problems raised in the above-mentioned background technology. [0004] To achi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/02C07K7/06C07K1/06C07K1/04A61P29/00A61P31/00
CPCA61P29/00A61P31/00C07K7/02C07K7/06Y02P20/55
Inventor 邵立
Owner 苏州埃莫尔医药科技有限公司
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