Use of circulating exosomal long non-coding RNA-tc0101441 as a marker for the diagnosis of endometriosis

An endometrium, non-coding technology, applied in the field of medical detection, can solve problems such as the difficulty of early diagnosis of endometriosis, achieve the effect of promoting invasion and metastasis, and the technical effect is obvious
CN108676874BActive Publication Date: 2021-05-18THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
Publication Date
2021-05-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

A circulating exosome long-chain non-coding RNA-TC0101441 is used as a marker for diagnosing endometriosis, and the gene sequence of the circulating exosome long-chain non-coding RNA-TC0101441 is as shown in SEQ ID NO.1 Show. Provided is a kit for diagnosing endometriosis, which contains a reagent for detecting circulating exosome long non-coding RNA-TC0101441, the reagent includes an upstream primer sequence and a downstream primer sequence, and the upstream primer sequence is as shown in SEQ ID NO .2, the downstream primer sequence is shown in SEQ ID NO.3. The present invention found that exosome TC0101441 can be detected in the serum of patients with endometriosis, and its expression level is significantly higher than that of women without endometriosis. Invasive biomarkers.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of medical detection, and relates to a serum and cell supernatant exosome lncRNA-TC0101441, specifically circulating exosome long-chain non-coding RNA-TC0101441 as a biomarker for diagnosing endometriosis and use in diagnostic reagents. Background technique

[0002] Endometriosis (EMs, referred to as "endometriosis") is an aggressive, estrogen-dependent disease characterized by the presence of endometrial glands and stroma in other parts of the uterus . The main clinical manifestations of endometriosis are pain and infertility, which seriously affect the quality of life of women. Endometriosis affects 10%-15% of reproductive-age women worldwide and more than 70 million people. Mild lesions of endometriosis may have tiny lesions on the surface of the organs, and severe lesions may lead to extensive adhesions of the bowel, bladder, and ureter in the pelvic organs.

[0003] Laparoscopy is not practical as an invasive...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More