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Preparation method of annular effervescent granules with health care effects

An effervescent granule and ring-shaped technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, can solve problems such as poor marketability, slow dissolution of granules, and physical injury.

Inactive Publication Date: 2018-10-23
BOZHOU QIANCAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of theaflavins in black tea is only 0.3-1.5%. Using black tea to prevent and treat fatty liver, the effect is very slow and cannot meet people's needs at all.
[0004] Granules are granular preparations made by combining drugs with suitable excipients. Most of the existing granules are based on symptoms by adding some or some pharmaceutical ingredients to prevent and treat certain diseases. Although the therapeutic effect of pharmaceuticals is relatively Significant, but long-term use will produce drug dependence, and will also cause certain damage to the body
In view of the slow dissolution rate of granules and poor marketability, many developers now make granules into effervescent granules. Although the dissolution rate has been improved, it is still difficult to meet the needs of consumers.
In addition, the existing granules have a bitter taste and cannot be swallowed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of ring-shaped effervescent granules with health care function, comprising the following steps:

[0021] (1) Dissolution: Weigh 4.2 parts of the catechin mixture and 16 parts of 95% ethanol in the corresponding weight parts and put them in the Erlenmeyer flask together, then heat and dissolve in the water bath, the temperature of the water bath heating is 76°C, and the water bath heating time is 18 minutes ;

[0022] (2) Enzymatic reaction: After cooling the solution obtained in step (1) to room temperature, weigh 0.06 parts of polyphenol oxidase and place it in a triangular flask, and then place the triangular flask in a gigahertz transverse electromagnetic transmission chamber for transverse electromagnetic wave treatment , the treatment time is 3 minutes, and then put the triangular flask in the water bath, the temperature in the water bath is 95-100°C, and keep heating until 95% of the ethanol evaporates to 1 / 8 of the original volume;

[0023] ...

Embodiment 2

[0031] A preparation method of ring-shaped effervescent granules with health care function, comprising the following steps:

[0032] (1) Dissolution: Weigh 4.5 parts of catechin mixture and 19 parts of 95% ethanol in corresponding weight parts and place them in a conical flask, and then heat and dissolve in a water bath. ;

[0033](2) Enzymatic reaction: After cooling the solution obtained in step (1) to room temperature, weigh 0.07 parts of polyphenol oxidase and place it in a triangular flask, and then place the triangular flask in a gigahertz transverse electromagnetic transmission chamber for transverse electromagnetic wave treatment , the treatment time is 4.5min, then put the triangular flask in the water bath, the temperature in the water bath is 97.5°C, keep heating until 95% ethanol volatilizes to 1 / 7 of the original volume;

[0034] (3) Suction filtration and drying: put the solution after the enzymatic reaction in step (2) into a centrifuge tube for suction filtrat...

Embodiment 3

[0042] A preparation method of ring-shaped effervescent granules with health care function, comprising the following steps:

[0043] (1) Dissolution: Weigh 4.8 parts of the catechin mixture and 22 parts of 95% ethanol in a conical flask, and then heat and dissolve in a water bath. The temperature of the water bath heating is 88°C, and the water bath heating time is 24 minutes ;

[0044] (2) Enzymatic reaction: After cooling the solution obtained in step (1) to room temperature, weigh 0.08 parts of polyphenol oxidase and place it in a triangular flask, and then place the triangular flask in a gigahertz transverse electromagnetic transmission chamber for transverse electromagnetic wave treatment , the treatment time is 6 minutes, then put the triangular flask in the water bath, the temperature in the water bath is 100°C, and keep heating until 95% of the ethanol evaporates to 1 / 6 of the original volume;

[0045] (3) Suction filtration and drying: put the solution after the enzy...

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Abstract

The invention discloses a preparation method of annular effervescent granules with health care effects, and belongs to the technical field of granule processing. The method comprises the following steps of (1) dissolution, (2) enzymatic reaction, (3) suction filtering drying, (4) weighing, (5) extrusion puffing treatment and (6) tableting treatment. The finally obtained granules have good performance, can be used for preventing and treating fatty liver, and also have the advantages that the mouthfeel is good; the dissolution speed is high; the bioavailability is high; the granules can be easily accepted by customers; the economic benefits are good; good market popularization values are realized.

Description

technical field [0001] The invention belongs to the technical field of granule processing, and in particular relates to a method for preparing ring-shaped effervescent granules with health-care effects. Background technique [0002] Fatty liver refers to the lesion of excessive fat accumulation in liver cells caused by various reasons. It is a common pathological change of the liver, rather than an independent disease. Fatty liver disease is seriously threatening the health of the Chinese people, becoming the second largest liver disease after viral hepatitis, the incidence rate is constantly increasing, and the age of onset is getting younger. Normal human liver tissue contains a small amount of fat, such as triglycerides, phospholipids, glycolipids, and cholesterol, and its weight is about 3% to 5% of the liver weight. If too much fat accumulates in the liver, it exceeds 5% of the liver weight. Or when more than 50% of the liver cells have fatty degeneration in histology,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/02A61K47/26A61K47/14A61K47/46A61K47/10A61K47/08A61K47/36A61K31/353A61P1/16A61P3/06
CPCA61P1/16A61P3/06A61K9/0007A61K9/1611A61K9/1617A61K9/1623A61K9/1641A61K9/1652A61K9/1664A61K31/353A61K2300/00
Inventor 郑秀文刘书彬李继武
Owner BOZHOU QIANCAO PHARMA
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