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Chitosan iodine biomaterial and preparation method thereof

A technology of biological materials and chitosan, which is applied in the direction of artificially synthesized active ingredients of polymeric materials, active ingredients of iodine compounds, drug combinations, etc. Promotes the growth of epithelial cells and vascular endothelial cells, reduces the source of collagen fibers, and prevents and adheres to the effect

Active Publication Date: 2018-11-02
JIANGSU HAIERZI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, normal saline is traditionally used as the flushing solution used in clinical practice. Conventional normal saline can neither effectively antibacterial, stop bleeding, prevent tissue adhesion, and promote wound healing, nor can it inhibit implantation metastasis due to adhesion of scattered tumor cells during surgery.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Chitosan iodine biological material, the main components and mass fraction of the biological bactericidal material are:

[0031] Iodine 0.05%;

[0032] Potassium iodide 0.1%;

[0033] Potassium iodate 0.4%;

[0034] Glycerin 1%;

[0035] Boric acid 0.1%;

[0036] Polyvinylpyrrolidone 5%;

[0037] Water-soluble chitosan 1.0%;

[0038] Sodium alginate 0.1%;

[0039] Calcium bicarbonate 0.05%;

[0040] Tea polyphenols 0.4%;

[0041] Phosphate buffered saline 5.0%;

[0042] Add water for injection or purified water to a sufficient amount.

[0043] The preparation method of described chitosan iodine biological material is prepared according to the following steps:

[0044] Step 1) After dissolving potassium iodide and potassium iodate with water for injection or purified water, add iodine and mix in a stirring tank to obtain liquid ①; then add boric acid, glycerin, and polyvinylpyrrolidone to mix, then add water for injection or purified water and stir to mix Unif...

Embodiment 2

[0048] Chitosan iodine biological material, the main components and mass fraction of the biological material are:

[0049] Iodine 0.5%;

[0050] Potassium iodide 0.3%;

[0051] Potassium iodate 0.25%;

[0052] Glycerin 3.0%;

[0053] Boric acid 0.2%;

[0054] Polyvinylpyrrolidone 10%;

[0055] Water-soluble chitosan 0.6%;

[0056] Sodium Alginate 1.0%;

[0057] Calcium bicarbonate 0.7%;

[0058] Tea polyphenols 0.4%;

[0059] Phosphate buffered saline 7.0%;

[0060] Add water for injection or purified water to a sufficient amount.

[0061] The preparation method of described chitosan iodine biological material is characterized in that: it is prepared according to the following steps:

[0062] Step 1) After dissolving potassium iodide and potassium iodate with water for injection or purified water, add iodine and mix in a stirring tank to obtain liquid ①; then add boric acid, glycerin, and polyvinylpyrrolidone to mix, then add water for injection or purified water and...

Embodiment 3

[0066] Chitosan iodine biological material, the main components and mass fraction of the biological bactericidal material are:

[0067] Iodine 1%;

[0068] Potassium iodide 0.5%;

[0069] Potassium iodate 0.3%;

[0070] Glycerin 3%;

[0071] Boric acid 0.15%;

[0072] Polyvinylpyrrolidone 15%;

[0073] Water-soluble chitosan 0.9%;

[0074] Sodium Alginate 0.7%;

[0075] Calcium bicarbonate 0.8%;

[0076] Tea polyphenols 0.35%;

[0077] Phosphate buffered saline 8.0%;

[0078] Add water for injection or purified water to a sufficient amount.

[0079] The preparation method of described chitosan iodine biological material is prepared according to the following steps:

[0080] Step 1) After dissolving potassium iodide and potassium iodate with water for injection or purified water, add iodine and mix in a stirring tank to obtain liquid ①; then add boric acid, glycerin, and polyvinylpyrrolidone to mix, then add water for injection or purified water and stir to mix Uniform...

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Abstract

The invention discloses a chitosan iodine biomaterial capable of killing bacteria and pathogenic microorganisms. The chitosan iodine biomaterial mainly comprises, by weight, 0.05-1% of iodine, 0.1-0.5% of potassium iodine, 0.15-0.4% of potassium iodate, 1-4% of glycerol, 0.1-0.2% of boric acid, 5-15% of polyvinylpyrrolidone, 0.1-1.0% of water-soluble chitosan, 0.1-1.0% of sodium alginate, 0.05-1.0% of calcium bicarbonate, 0.1-0.4% of tea polyphenols, 5.0-8.0% of buffer phosphate, and the balance of injection water or purified water. The chitosan iodine biomaterial is nontoxic, nonirritating ornon-allergic to human, has good biodegradability and biocompatibility, has good sterilizing and wound-healing functions, and can prevent implantation metastasis due to scattering of tumor cells of human cavity internal membranes during tumor surgery.

Description

technical field [0001] The invention relates to a medical sterilization, antibacterial, anti-adhesion, biological material and skin and mucous membrane external disinfection and surgical field skin and mucous membrane biological material used in the perioperative period, in particular to a chitosan iodine biological material and a preparation method thereof. Background technique [0002] At present, the traditional preparation of iodine-containing preparations is mainly polyvinyl ether and polyvinylpyrrolidone-embedded iodine preparations. The defect of this iodine preparation is that high-energy iodine can be stored for a long time, but the available iodine below 5000PPm iodine solution is easy to volatilize. It is very effective to be prepared into tincture of iodine, but it is very irritating to the skin and mucous membranes. Low-concentration chitosan iodine microsphere sol solution preparation is still a blank. [0003] In surgical infectious operations such as intesti...

Claims

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Application Information

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IPC IPC(8): A61K33/22A61K9/10A61K31/353A61K31/722A61K31/734A61K31/79A61K33/18A61K47/02A61P31/04A61P35/00A61P41/00
CPCA61K9/10A61K31/353A61K31/722A61K31/734A61K31/79A61K33/18A61K33/22A61K47/02A61P31/04A61P35/00A61P41/00A61K2300/00
Inventor 胡军胡静雯胡梦
Owner JIANGSU HAIERZI BIOTECH CO LTD
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