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Pharmaceutical formulation for treating alzheimer's disease

A technology of Alzheimer's disease and drugs, which is applied in the direction of medical formulas, drug combinations, medical preparations containing active ingredients, etc., and can solve problems such as drug dependence

Active Publication Date: 2018-11-02
JINGGANGSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are already effective acetylcholinesterase inhibitors, because different groups of people have different tolerances to different drugs, the efficacy and dosage of different drugs vary from person to person, and drug dependence is prone to occur when taking the same drug for a long time. Therefore, there is a continuous need to develop new acetylcholinesterase inhibitor drugs

Method used

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  • Pharmaceutical formulation for treating alzheimer's disease
  • Pharmaceutical formulation for treating alzheimer's disease
  • Pharmaceutical formulation for treating alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A medicinal formula for treating Alzheimer's disease, which is prepared by mixing the following substances: 5 parts of Lycopodium cypress extract, 5 parts of Lycopodium cypress extract, and 100 parts of auxiliary materials;

[0038] The extract of Lycomus pine is a crude extract of Lycopodium; the crude extract of Lycopodium is prepared according to the following method: take 2 kg of dried Lycopodium whole herb, crush it with a volume fraction of 95% of 8 times the mass % ethanol solution at room temperature for 3 times, each time for 2h, filter, collect all the extracts, and concentrate the extracts under reduced pressure to obtain 180g of ethanol-free Lycopodium extract, then dry to obtain the crude extract of Lycopodium chinensis thing.

[0039] The cypress pine extract is the rough extract of cypress pine; the crude pine extract is extracted according to the following method: take 2 kg of the whole herb of dry cypress pine, grind it with 8 times the mass fraction of...

Embodiment 2

[0042] A medicinal formula for treating Alzheimer's disease, which is prepared by mixing the following substances: 10 parts of Lycopodium cypress extract, 10 parts of Lycopodium cypress extract, and 300 parts of excipients;

[0043] The extract of Lycopodium is the crude extract of Lycopodium; the preparation method of the crude extract of Lycopodium is the same as in Example 1.

[0044] The cypress pine extract is the rough extract of cypress pine; the preparation method of the cypress pine crude extract is the same as that in Example 1.

[0045] The auxiliary material is corn starch.

Embodiment 3

[0047] A medicinal formula for treating Alzheimer's disease, which is prepared by mixing the following substances: 8 parts of Lycopodium cypress extract, 7 parts of Lycopodium cypress extract, and 150 parts of excipients;

[0048] The extract of Lycopodium is the crude extract of Lycopodium; the preparation method of the crude extract of Lycopodium is the same as in Example 1.

[0049] The cypress pine extract is the rough extract of cypress pine; the preparation method of the cypress pine crude extract is the same as that in Example 1.

[0050] The auxiliary material is a mixture of cornstarch, talcum powder and sodium lauryl sulfate in a mass ratio of 1:4:0.2.

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Abstract

The invention belongs to alzheimer's drug technology field, which specifically relates to a pharmaceutical formulation for treating alzheimer's disease and prepared by mixing the following materials:5-10 parts of palhinhaea cernua extrative, 5-10 parts of lycopodium obscurum extrative, 100-300 parts of auxiliary materials, the palhinhaea cernua extrative is the coarse extractive of the palhinhaeacernua or fine extractive of the palhinhaea cernua, the lycopodium obscurum extrative is the coarse extractive of the lycopodium obscurum or fine extractive of the lycopodium obscurum, the auxiliarymaterials are microcrystalline cellulose, corn starch, talcum powder, one or a plurality of combination of lauryl sodium sulfate, the compounds contained in extratives from palhinhaea cernua and lycopodium obscurum has a inhibition rate of acetylcholinesterase activity to be 35.67-81.17%, which can provide AD prevention and cure with candidate drug leading structure or model compounds.

Description

technical field [0001] The invention belongs to the technical field of senile dementia drugs, in particular to a medicinal formula for treating senile dementia. Background technique [0002] Alzheimer's disease (also known as Alzheimer's, Alzheimer's Disease, AD) is one of the important diseases that seriously threaten human life and health after cardiovascular disease and tumors. Research hotspots in the field of pharmacy. [0003] In the prior art, drugs for treating Alzheimer's disease are mainly divided into anxiolytics, antidepressants, antipsychotics and nootropic drugs. Among them, anti-anxiety drugs include alprazolam, oxazepam (norxazepam), lorazepam (rolla) and triazolam (Hai Leshen), etc., but the dosage of these drugs should be small and not easy to use for a long time Otherwise, side effects such as drowsiness and slurred speech may occur; antidepressants such as doxepin (doxepin) and maprotiline are suitable for patients with depressive symptoms; antipsychoti...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61P25/28A61K31/56A61K31/4375A61K31/4748A61K31/395A61K31/59C07D471/22C07D471/08C07J67/00C07C401/00C07C35/36C07C29/76C07C29/86C07D225/04C07D225/06
CPCA61K31/395A61K31/4375A61K31/4748A61K31/56A61K31/59A61K36/11A61K2236/333A61P25/28C07B2200/07C07C29/76C07C29/86C07C35/36C07C401/00C07D225/04C07D225/06C07D471/08C07D471/22C07J67/00C07C2602/10A61K2300/00
Inventor 殷帅文朱立成
Owner JINGGANGSHAN UNIVERSITY
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