The invention discloses a pharmaceutical composition for treating chicken gout and a preparation method thereof. The pharmaceutical composition comprises the following raw medicinal materials: achyranthes aspera, begonia roots, China rose, lacca, lamiophlomis rotate, herba lycopi, madder, lycopodium obscurum, huechys, lantana camara, fringed iris herb, aizoon stonecrop herb, piper hancei, peruvian groundcherry herb, grub, homalocladium platycladum, cinnamon, semen brassicae, Indian kalimeris herb, Chinese tupistra rhizome, camphortree, zanthoxylum planispinum, osmorhiza aristata, panax pseudo-ginseng Wsll. Var, girald jasmine root, radix glehniae, roundleaf dutchmanspipe root, baeckea frutescens, zornia diphylla pers, cyrtomium fortunei, amur lilac, celandine and blumea. The pharmaceutical composition disclosed by the invention has the beneficial effects of promoting blood circulation and removing stasis, relieving swelling and stopping pain, dredging channels and dispelling cold, warming blood and promoting granulation, and diminishing inflammation and reducing internal heat; syndrome differentiation and treatment are carried out on the basis of holistic view, the targeting property is high, the efficacy is capable of directly achieving lesions to effectively control the condition, and the curative effect is remarkable; moreover, by using the pure natural traditional Chinese medicinal materials, the pharmaceutical composition is cheap, safe and effective, free from medicine residue, and capable of improving the appetite of chicken and meeting the nutritional needs thereof.