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a flower-like structure nise 2 The preparation method and its application

A flower-like structure and variety of technology is applied in the field of glucose sensors to achieve the effects of improving stability, high sensitivity and simple preparation method

Active Publication Date: 2022-04-22
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the main component of glucose oxidase is protein, so its stability is easily affected by the surrounding temperature, pH and humidity

Method used

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  • a flower-like structure nise <sub>2</sub> The preparation method and its application
  • a flower-like structure nise <sub>2</sub> The preparation method and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: In this embodiment, the flower-like structure NiSe 2 The preparation method is carried out according to the following steps: add 0.45g selenium powder, 0.38g nickel nitrate hexahydrate and 4mL ammonia water into 40mL deionized water, and ultrasonically dissolve it completely under 40KHz; Under hydrothermal reaction for 12h; centrifuge wash with absolute ethanol at 3000rpm, dry at 50°C for 6h to get flower-like structure NiSe 2 .

Embodiment 2

[0029] Embodiment 2: In this embodiment, the flower-like structure NiSe 2 The preparation method is carried out according to the following steps: 1.50g of selenium powder, 0.58g of nickel nitrate hexahydrate and 4mL of ammonia water are added to 40mL of deionized water, and ultrasonicated at 40KHz until completely dissolved; Hydrothermal reaction at ℃ for 12h; centrifuge washing with absolute ethanol at 3000rpm, drying at 100℃ for 12h to obtain flower-like structure NiSe 2 .

Embodiment 3

[0030] Embodiment 3: NiSe prepared by the method of Embodiment 1 in this embodiment 2 The modified glassy carbon electrode is used for the enzyme-free glucose electrochemical sensor, and the specific scheme is: the preparation method of the electrode for the enzyme-free glucose electrochemical sensor is carried out according to the following steps:

[0031] Step 1, the flower-like structure NiSe prepared by the preparation method described in Example 1 2 Add in deionized water, stir evenly to get NiSe 2 The concentration is 1.0mg / mL -1 Solution A;

[0032] Step 2, dissolving 0.1 mg of chitosan (CS) in 0.5 mL of acetic acid solution with a mass concentration of 1%, followed by ultrasonic treatment at 40 KHz for 45 min to obtain solution B;

[0033] Step 3: Take 50 μL of solution A, add it to solution B, and disperse it ultrasonically to obtain dispersion A;

[0034] Step 4: Pretreat the glassy carbon electrode with a diameter of 3 mm until the peak potential difference is 8...

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Abstract

A flower-like structure NiSe 2 The preparation method and application thereof belong to the technical field of glucose sensors. The invention aims to solve the technical problem of unstable detection of blood sugar concentration in the prior art. The present invention prepares flower-like NiSe with multiple active sites and excellent conductivity through a simple hydrothermal reaction 2 , flower-like NiSe 2 With excellent electrical conductivity and a large number of redox active sites, a biomimetic structure NiSe is built on the glassy carbon electrode 2 ; Can be used for high-sensitivity enzyme-free electrochemical glucose sensing. The flower-like structure NiSe prepared by the present invention 2 Biosensors have high sensitivity, good stability, and wide linear range, and are widely used in the monitoring of blood sugar and urine sugar in diabetic patients.

Description

technical field [0001] The invention belongs to the technical field of glucose sensors; relates to a flower-like structure NiSe 2 The preparation method and its application. Background technique [0002] Diabetes has become one of the diseases that seriously threaten human health since the 21st century. Therefore, rapid and real-time monitoring of blood glucose concentration is crucial for the clinical diagnosis and treatment of diabetes. At present, many methods have been used to detect the concentration of blood sugar, such as electrochemical method, fluorescence detection method and so on. Due to the characteristics of fast response and good economic benefits, the electrochemical detection method is widely used in the field of blood glucose concentration detection. [0003] This detection method is mainly based on the oxidation-reduction reaction between glucose oxidase and glucose, which produces a change in current, and the concentration of glucose can be determined ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 齐殿鹏田宫伟刘妍徐洪波钟正祥
Owner HARBIN INST OF TECH
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