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An antidepressant drug and its oral granules and pharmaceutical uses

An antidepressant and granule technology, applied in the field of medicine, can solve the problems of prolonging the taking time and increasing the dose, etc.

Active Publication Date: 2019-03-26
程世宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, increasing the dose and prolonging the time of taking the drug will cause withdrawal symptoms such as anxiety and sleep disturbance.

Method used

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  • An antidepressant drug and its oral granules and pharmaceutical uses
  • An antidepressant drug and its oral granules and pharmaceutical uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Oral granules for the treatment of depression

[0036] Prescription of raw and auxiliary materials: mirtazapine 12g, compound (VIIIA) 2g, mannitol 247.2g, hydroxypropyl methylcellulose 96g, aspartame 2.4g and an appropriate amount of purified water.

[0037] Preparation:

[0038] The prescription amount of mirtazapine and compound (VIIIA) were pulverized through 80 mesh sieve to obtain main drug powder; the prescription amount of mannitol, hydroxypropyl methylcellulose and aspartame were respectively pulverized through 60 mesh sieve to obtain excipient powder ; Mix the main ingredient powder and auxiliary material powder evenly, add purified water to prepare soft material, pass through a 30-mesh sieve to granulate, dry in vacuum at 30°C for 60 minutes, granulate with a 24-mesh sieve, and pack separately.

Embodiment 2

[0039] Example 2 Oral granules for the treatment of depression

[0040] Prescription of raw and auxiliary materials: 10 g of mirtazapine, 2 g of compound (VIIIA), 206 g of mannitol, 80 g of hydroxypropyl methylcellulose, 2 g of aspartame and an appropriate amount of purified water.

[0041] Preparation:

[0042] The prescription amount of mirtazapine and compound (VIIIA) were pulverized through 80 mesh sieve to obtain main drug powder; the prescription amount of mannitol, hydroxypropyl methylcellulose and aspartame were respectively pulverized through 60 mesh sieve to obtain excipient powder ; Mix the main ingredient powder and auxiliary material powder evenly, add purified water to prepare soft material, pass through a 30-mesh sieve to granulate, dry in vacuum at 30°C for 60 minutes, granulate with a 24-mesh sieve, and pack separately.

Embodiment 3

[0043] Embodiment 3 oral granules for treating depression

[0044] Prescription of raw and auxiliary materials: 10 g of mirtazapine, 2 g of compound (VIIIB), 206 g of mannitol, 80 g of hydroxypropyl methylcellulose, 2 g of aspartame and an appropriate amount of purified water.

[0045] Preparation method: take the prescribed amount of mirtazapine and compound (VIIIB) and pulverize them through a 80-mesh sieve to obtain the main drug powder; take the prescribed amount of mannitol, hydroxypropyl methylcellulose and aspartame and pulverize them through a 60-mesh sieve respectively, Obtain auxiliary material powder; mix the main drug powder and auxiliary material powder evenly, add purified water to prepare a soft material, granulate through a 30-mesh sieve, vacuum-dry at 30°C for 60 minutes, granulate with a 24-mesh sieve, and pack separately.

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PUM

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Abstract

The invention belongs to the field of medicine, and especially relates to an anti-depressant drug and its oral particulate agent and a pharmacy purpose thereof. The anti-depressant drug is prepared bya pharmaceutical adjuvant, mirtazapine and an isoquinoline compound. The pharmaceutical adjuvant of the oral particulate agent comprises mannitol, hydroxypropyl methyl cellulose, citric acid and aspartame. With low dosage usage of mirtazapine, the anti-depressant drug can perform obvious anti-depression effect and has good safety.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an antidepressant medicine, oral granules and pharmaceutical application thereof. Background technique [0002] Depression is a common mood disorder syndrome characterized by low mood, reduced social willingness, and suicidal tendencies. The disease is a mental disease that seriously endangers the physical and mental health of human beings. With the acceleration of the pace of life and the increase of social pressure, the incidence of the disease shows a clear upward trend and a younger trend. According to the World Health Organization, there are currently 340 million depression patients in the world, and the number of depression patients in China has exceeded 26 million. 28.5-63.7% of depressed patients have suicidal behavior, and about 15% eventually commit suicide. [0003] The exact pathogenesis of depression is still unclear. There are currently many hypotheses on the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/55A61K31/4741A61K9/16A61P25/24
CPCA61K9/1623A61K9/1652A61K31/4741A61K31/55A61P25/24A61K2300/00
Inventor 程世宏汪婧王倩燕徐虹
Owner 程世宏
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