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Lateral deviation micro column array chip and application thereof

A microcolumn array and lateral offset technology, applied in the field of separation, can solve the problems of low separation flux, narrow separation channel, and easy blockage of the channel, and achieve the effect of improving separation efficiency

Active Publication Date: 2018-11-06
ZIGZAG BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the condition of a certain separation channel length, the smaller the offset angle is, the narrower the separation channel is, and the narrow separation channel results in low separation flux, and the channel is easy to be blocked, so it is impossible to separate large-volume samples. Pillar array device or chip applications

Method used

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  • Lateral deviation micro column array chip and application thereof
  • Lateral deviation micro column array chip and application thereof
  • Lateral deviation micro column array chip and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0050] to have Figure 5 The laterally offset microcolumn array chip of the microcolumn unit of the structure shown is taken as an example, and the separation effect of the laterally offset microcolumn array chip of the present invention is evaluated. The chip substrate is inorganic glass, and the cover is polydimethyl silicone.

[0051] 1. The critical separation dimension of different micropillar structures with the same array size and offset angle

[0052] In order to compare the influence of different microcolumn structures on the critical separation size, the figure 1 The inlet and outlet designs of the chip shown, the micropillar structures in the chip are circular micropillars, triangular micropillars, Figure 5 Composite microcolumns shown. The diameter of the circular micro-pillar is 10 microns, the distance between rows is 10 microns, the distance between columns is 10 microns, and the array is laterally offset by 6 degrees; The lateral offset of the array is 6 d...

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Abstract

The invention discloses a lateral deviation micro column array chip and application thereof. The lateral deviation micro column array chip comprises lateral deviation micro column arrays arranged intolines or arranged into rows; each subsequent line or subsequent row of lateral deviation micro column unit deviates according to a certain angle relative to the front line or the front row; one or aplurality of channels are arranged in each micro column unit; in one or a plurality of channels, the opening direction of at least one channel is different from the deviation direction of the lateraldeviation micro column array. The dimension in separation fluid is more precise; the effect of filtering small-dimension particles is achieved, so that the big-dimension particles have the enriching effects before entering the next array; the critical separation dimension of the micro column array is reduced; the separation flux is higher; the separation volume is greater.

Description

technical field [0001] The invention relates to the field of separation technology, in particular to a lateral offset microcolumn array chip and its application. Background technique [0002] In the fields of biology, medicine, chemistry and industry, it is a basic analysis method to separate substances or particles according to their size. Common methods such as filtration, chromatographic separation, inertial force, eddy current and lateral offset microcolumn array, etc. . Among these technologies, the laterally offset micropillar array technology is widely used due to its dimensionally precise separation. array, the micropillars of each subsequent column or subsequent row are offset by a certain angle relative to the previous column, arranged according to the size and angle of the micropillar array, and each micropillar array has a specific material critical sorting size (diameter), When the large particles larger than the critical diameter collide with the micro-pillar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00
CPCC12M23/16B01L3/502746B01L3/502761B01L2200/0652B01L2200/027
Inventor 刘宗彬
Owner ZIGZAG BIOTECH LTD
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