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Characteristic extraction and classification method and device for DNA (Deoxyribo-Nucleic Acid) binding protein sequence information

A technology that combines protein and sequence information, applied in the field of computer biology

Inactive Publication Date: 2018-11-23
HENAN NORMAL UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to provide a DNA-binding protein sequence information feature extraction and classification method and device to solve the unsolved classification problems of DNA-binding protein sequence data in the prior art

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  • Characteristic extraction and classification method and device for DNA (Deoxyribo-Nucleic Acid) binding protein sequence information
  • Characteristic extraction and classification method and device for DNA (Deoxyribo-Nucleic Acid) binding protein sequence information
  • Characteristic extraction and classification method and device for DNA (Deoxyribo-Nucleic Acid) binding protein sequence information

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[0038] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments, but the embodiments of the present invention are not limited thereto.

[0039] Examples of the method for extracting and classifying DNA-binding protein sequence information of the present invention:

[0040] The overall scheme of the present invention is as figure 1 Shown.

[0041] The commonly used structure databases of DNA binding proteins include: Protein Data Bank (PDB) NDB, ProNuc, and structure classification databases SCOP and CATH; commonly used sequence databases include: SWISS-PROT, PIR, OWL, NRL3D, TrEMBL, etc. Among them, the protein database was established in 1971 by Walter Hamilton of Brookhaven National Laboratory. It is now managed by the Structural Biology Cooperative Research Association (RCSB) and has become an international organi...

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Abstract

The invention relates to a characteristic extraction and classification method and device for DNA (Deoxyribo-Nucleic Acid) binding protein sequence information. The method comprises the following steps that: firstly, carrying out theory argumentation, and analyzing and arranging collected data to obtain a reliable dataset with a biological meaning and a statistical meaning; then, extracting effective protein sequence data characteristic parameters from a complex protein three-dimensional structure as a key link which is a way of converting sequence character information into digital characteristic information, designing a reasonable classification algorithm for extracted characteristic data, and screening the characteristics favorable for classification for realizing target classification;and finally, adopting a reasonable and fair evaluation system, including testing methods, checking means, evaluation index selection and the like, for classification performance. By use of the method, requirements on high-flux protein sequencing function annotation can be met, automated DNA binding protein sequence function annotation can be realized, and meanwhile, the characteristics which areput forward can assist biologists in carrying out experimental analysis and research on the DNA binding protein sequence.

Description

Technical field [0001] The invention belongs to the field of computer biology technology, and specifically relates to a method and device for extracting and classifying DNA binding protein sequence information. Background technique [0002] With the continuous growth of biological data, how to dig out valuable knowledge from a large amount of data is a very challenging and very interesting work, which also promotes the intersection of mathematics, computer science and biology. A new research field-bioinformatics was born. [0003] With the continuous development of protein structure determination technology and high-throughput sequencing technology, a large amount of DNA-binding protein structure data and sequence data have been generated, laying a data foundation for computational methods to study the functions of DNA-binding proteins. DNA binding proteins are divided into single-stranded DNA-binding proteins (SSBs) and double-stranded DNA-binding proteins (DSBs). SSBs are mainly...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/22
Inventor 王伟
Owner HENAN NORMAL UNIV
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