Preparation method of nanometer chemotherapeutic drug carrier

Abstract

The invention discloses a preparation method of a nanometer chemotherapeutic drug carrier. The preparation method comprises the steps that manganese-doped prussian blue nanoparticles and manganese-doped prussian blue@polypyrrole nanoparticles are synthesized firstly, then 4 mg of the manganese-doped prussian blue nanoparticles and the manganese-doped prussian blue@polypyrrole nanoparticles are weighed to be dissolved in a 4 ml of PBS buffer solution, and stirring is conducted to prepare a uniform solution; 1 mg of doxorubicin hydrochloride (DOX) is weighed to be dissolved in a 1 ml of PBS solution and dropped into a nanoparticle solution under the light avoidance condition, and after dropping is finished, 75 mg of sodium hyaluronate is weighed to be added to the solution to be stirred at the low speed for 24 h; and then a dialysis bag with the molecular weight cut-off being 14 KD is selected to conduct light avoidance dialysis for 24 h, and a final product is obtained and placed in a refrigerator at 4 DEG C for light avoidance preservation. The preparation method has great significance in preparing the nanometer chemotherapeutic drug carrier with MRI and PTT functions to load chemotherapeutic drugs, and realizing the nanoparticles with a diagnosis and treatment integrated function.

Description

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AI Technical Summary

Benefits of technology

This patented technology describes how we use different types of materials called prussium (Pseudolarix) or iron pigments to create special structures like quantum dots that have specific properties such as magnetism, photoconductivity, and absorption capabilities at certain wavelength ranges. These new compounds help deliver medicine specifically towards cancerous areas while reducing its harmful impact upon healthy parts nearby. They may be combined with other medications to improve their efficacy against various diseases caused by these conditions.

Problems solved by technology

This patents discusses different ways how molecular medicine works effectively when it targets specific areas inside or outside living bodies without harmful reactions caused by other substances like medicines. However, current techniques such as photothermal therapies require long exposure times and may result in delayed growth rates. Chemoimmunotherapeuction involves delivering small particles called platins onto affected parts through various routes including intramascular implants. While these approaches provide advantages over existing methodology they still suffer from challenges associated with their ability to specifically focus on certain regions within the body while avoiding unwanted collaterals during radiation sessions.

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