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Multi-omics based cervical carcinoma characteristic obtaining method and system

A cervical cancer and methylation technology, applied in the field of data processing, can solve the problems of poor accuracy and incomplete feature extraction of cervical cancer patients

Pending Publication Date: 2018-12-07
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Abstract
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  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a multi-omics-based cervical cancer feature acquisition method and system to alleviate the technical problems of poor accuracy and incomplete feature extraction when traditional methods are used to classify cervical cancer patients

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  • Multi-omics based cervical carcinoma characteristic obtaining method and system
  • Multi-omics based cervical carcinoma characteristic obtaining method and system
  • Multi-omics based cervical carcinoma characteristic obtaining method and system

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Embodiment 1

[0033] According to an embodiment of the present invention, an embodiment of a method for acquiring features of cervical cancer based on multi-omics is provided.

[0034] figure 1 is a flow chart of a multi-omics-based cervical cancer feature acquisition method according to an embodiment of the present invention, such as figure 1 As shown, the method includes the following steps:

[0035] Step S102, obtaining the methylation data to be analyzed, wherein the methylation data is the methylation data in cervical cancer detection, including the value of the target methylation site of the object to be analyzed, and the number of objects to be analyzed is at least indivual;

[0036] It should be noted that, in the embodiment of the present invention, the methylation data may not only be the methylation data in cervical cancer detection, but may also be the methylation data in other tumoromics research processes. Wherein, in the following embodiments, the methylation data is descr...

Embodiment 2

[0104] The embodiment of the present invention also provides a multi-omics-based cervical cancer feature acquisition system. The multi-omics-based cervical cancer feature acquisition system is mainly used to perform the multi-omics-based cervical cancer detection system provided by the above content of the embodiment of the present invention. The cancer feature acquisition method, the multi-omics-based cervical cancer feature acquisition system provided by the embodiment of the present invention will be specifically introduced below.

[0105] Figure 9 is a schematic diagram of a multi-omics-based cervical cancer feature acquisition system according to an embodiment of the present invention, such as Figure 9 As shown, the cervical cancer feature acquisition system based on multi-omics mainly includes: a first acquisition unit 91, a classification unit 92, a first extraction unit 93 and a second extraction unit 94, wherein:

[0106] The first acquisition unit 91 is configured...

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Abstract

The invention provides a multi-omics based cervical carcinoma characteristic obtaining method and a system. The multi-omics based cervical carcinoma characteristic obtaining method comprises followingsteps: methylation data for analysis is obtained, wherein the methylation data is obtained in cervical carcinoma detection, and comprises target methylation site values of a plurality of objects foranalysis; based on the target methylation site values of the plurality of objects for analysis, the objects are subjected to subgroup classification so as to obtain a plurality of subgroups; the subgroups are subjected to first characteristic extraction based on the methylation data so as to obtain epigenetic characteristics; the subgroups are subjected to second characteristic extraction based onthe gene expression data of the objects for analysis so as to obtain gene expression characteristics. The transcription factor combination characteristics in epigenetic characteristics and the differential expression gene in gene expression characteristics can be used for determining target gene expression function characteristics, and solving problems in the prior art that the accuracy of classification of cervical carcinoma patients using a conventional method is poor, and characteristic extraction is not comprehensive.

Description

technical field [0001] The present invention relates to the technical field of data processing, in particular to a multi-omics-based cervical cancer feature acquisition method and system. Background technique [0002] The heterogeneity that exists among cervical cancer patients allows potential subgroups to exist in the affected population, and different subgroups exhibit different characteristics and different responses to treatment. The traditional classification method of cervical cancer patients is generally based on the clinical stage of the patient or the histological characteristics of the corresponding cancer tissue, without considering the heterogeneity among patients and the complexity of the disease at the internal molecular level such as DNA and gene expression. sex. Among them, according to the clinical stage of the patient, the International Federation of Gynecology and Obstetrics (FIGO) system is usually used to check the size of the nucleus of the cancer cel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G06F19/20G06F19/24
CPCC12Q1/6886C12Q2600/154C12Q2600/158
Inventor 李霞蔡云鹏
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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