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Application of iron removal drug to preparation of H7N9 type bird flu prevention and treatment drugs

A bird flu and drug technology, applied in the field of biomedicine, can solve problems such as poor understanding of iron homeostasis

Inactive Publication Date: 2018-12-21
ZHEJIANG UNIV
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Problems solved by technology

[0004] At present, it is known that iron homeostasis in the body is related to various viral infections, such as HIV and hepatitis B virus, etc., but the role of iron homeostasis in the prevention and treatment of H7N9 avian influenza is still poorly understood. It is of great significance to the prevention of H7N9 bird flu

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  • Application of iron removal drug to preparation of H7N9 type bird flu prevention and treatment drugs
  • Application of iron removal drug to preparation of H7N9 type bird flu prevention and treatment drugs
  • Application of iron removal drug to preparation of H7N9 type bird flu prevention and treatment drugs

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Embodiment Construction

[0021] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. All other embodiments obtained by persons of ordinary skill in the art based on the embodiments of the present invention belong to the protection scope of the present invention.

[0022] Desferrioxamine: desferrioxamine B, a chelating agent, mainly complexes with trivalent ions and trivalent aluminum ions to form complexes, and the complex formation constants are 1031 and 1025 respectively. But for divalent ions such as ferrous (Fe++ ), copper (Cu++), zinc (Zn++) and calcium (Ca++), etc. have very low affinity, and their complex formation constants are 1014 or lower. Chelation is performed on a 1:1 molar basis.

[0023] Experiment 1: Low serum iron levels in patients ...

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Abstract

The invention relates to the field of medical science. By detecting the serum iron content in the body of an H7N9 type bird flu patient, it is discovered that decreasing of the serum iron plays the important role in engine body resisting H7N9 bird flu infection, and application of the iron removal drug to preparation of the H7N9 type bird flu prevention and treatment drugs is disclosed through experimental data, theoretical support is provided for prevention and treatment of H7N9 bird flu virus, and particularly basis is provided for research and development of drugs for preventing and treating H7N9 bird flue virus.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of deferoxamine, an iron-removing drug, in the preparation of drugs for the prevention and treatment of H7N9 avian influenza. Background technique [0002] H7N9 avian influenza is an avian influenza virus belonging to the genus Influenza A in the Orthomyxoviridae family. The H7N9 subtype avian influenza virus is a new type of reassortant virus, and its internal genes are derived from the H9N2 avian influenza virus. The main source of infection of the virus is live poultry. After human contact with the virus source of infection, avian influenza infection will occur. After being infected with H7N9 avian influenza virus, symptoms of acute respiratory infectious disease will appear, mainly manifested as fever, cough, sputum, chest pain, shortness of breath. Difficulties, etc. At present, there is no specific vaccine against H7N9 avian influenza, and its pathogenesis still ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/16A61P31/16
CPCA61K31/16A61P31/16
Inventor 王福俤周继勇
Owner ZHEJIANG UNIV
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