A compound medicament and its preparation method and use

Abstract

The invention discloses a compound medicament. The compound medicament comprises a main drug, which is cefquinome or salt thereof and tedizolid or phosphate thereof. The compound medicament is a breast injectant in dosage form and is used for treating mastitis of cows in the lactation period. The invention further discloses a preparation method of the compound medicament, the method comprises thefollowing steps: mixing the main drug, a stabilizing agent and a solvent uniformly, and enabling the main drug and an ingredient to be dissolved to obtain a settled solution; enabling an antioxidant,a synergist and a suspending agent to be mixed with the settled solution, and stirring uniformly; afterwards, grinding for 20-50 min by using a colloid mill to obtain a finished product. The compoundmedicament realizes a synergistic anti-microbial effect through two kinds of mechanisms in which the cefquinome or the salt thereof and the tedizolid or the phosphate thereof are jointly combined, thesynthesis of a cell wall is jointly inhibited and the synthesis of protein is inhibited. The compound medicament further has the advantages of good fluidity, good drug release performance and convenient drug administration.

Description

technical field [0001] The present invention relates to the technical field of animal medicine, in particular to a compound medicament and its preparation method and application. Background technique [0002] Dairy cow mastitis is a common disease in the dairy cattle breeding industry, which exists widely in all parts of the world. Cow mastitis can be divided into clinical mastitis and recessive mastitis. The clinical symptoms of clinical mastitis are breast swelling, heating, hyperemia, pain, unsmooth milk discharge, scarce milk, or even stop secretion, and enlarged lymph nodes. The milk contains milk clots or flocs, and in severe cases, blood and pus are mixed. Sick cows are unwilling to stand up, their hind limbs are spread apart when walking, and they refuse to breastfeed and artificially milk young animals. Appetite, decreased rumination and lack of energy appear, and with the development of the course of the disease, other mammary glands will also be infected, and t...

AI Technical Summary

Problems solved by technology

For a long time, antibiotics have been listed as the first choice for the treatment of mastitis all over the world, but with the widespread use of antibiotics, drug-resistant strains have gradually developed, and a large number of multidrug-resistant strains, especially methicillin-resistant strains, have emerged. The emergence of drug-resistant Staphylococcus aureus isolates (MRSA) makes the treatment very difficult, aggravates the disease, and increases the culling rate of dairy cows. At present, few new products that can be used for the treatment of mastitis in dairy cows are effective for MRSA. New effective drugs or treatments have become the focus of medical workers

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