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Enhanced cancer immunotherapy by microneedle patch-assisted delivery

A technology of microneedle sticking and immunotherapy, which is applied in the direction of microneedle, immunoglobulin, immune system assessment, etc., and can solve the problem of high treatment cost

Pending Publication Date: 2018-12-21
NORTH CAROLINA STATE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Treatment costs are also prohibitively high due to the amount of inhibitor required

Method used

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  • Enhanced cancer immunotherapy by microneedle patch-assisted delivery
  • Enhanced cancer immunotherapy by microneedle patch-assisted delivery
  • Enhanced cancer immunotherapy by microneedle patch-assisted delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] Example 1. Enhancement of cancer immunotherapy by microneedle patch-assisted delivery of anti-PD1 antibody

[0139] Material

[0140] All chemicals were obtained from commercial sources and used without further purification. Sodium hyaluronate (molecular weight of 300 kDa) was purchased from Freda Biochem Co., Ltd. (Shandong, China). Alginate (Mn=160kDa), dextran (Mn=9-11kDa), glucose oxidase (GOx) and bovine catalase (CAT) were purchased from Sigma-Aldrich. 2-Ethoxy-1-propene was obtained from Synthonix Corporation. Deionized water was produced by a Millipore NanoPure purification system (resistivity above 18.2 MΩ·cm-1). All organic solvents used for synthesis and analysis were ordered from Fisher Scientific and used as received.

[0141] cell line

[0142] The mouse melanoma cell line B16F10 was purchased from the American Type Culture Collection. For bioluminescent in vivo tumor imaging, B16F10-luc cells were kindly provided by Dr. Leaf Huang, UNC. Cells were ...

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Abstract

Disclosed herein are self-degradable microneedle devices for the controlled-release of an immunotherapeutic agent. Also disclosed are methods for treating a disease (for example, cancer) using a self-degradable microneedle patch for the sustained delivery of an immunotherapeutic agent (for example, a PD1 antibody).

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Patent Application No. 62 / 301,789, filed March 1, 2016, the disclosure of which is expressly incorporated herein by reference. technical field [0003] The present disclosure relates to microneedle devices and methods for treating diseases (eg, cancer) using self-degradable microneedle patches for sustained delivery of immunotherapeutic agents (eg, anti-PD1 antibodies). Background technique [0004] Skin cancer is the most common malignancy in humans, especially in Caucasians. Current estimates suggest that one in five Americans will develop skin cancer in their lifetime ( M. et al. Cancer Lett. 2015, 357, (1), 8-42; Rogers, H.W.; Weinstock, M. et al. Arch. Dermatol. 2010, 146, (3), 283-287). For skin cancer treatment, immunotherapy has been intensively studied in the past several years (Chinembiri, T.N. et al. Molecules 2014, 19, (8), 11679-11721; Pardoll, D.M. ...

Claims

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Application Information

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IPC IPC(8): A61B5/1486A61M5/158A61M37/00A61M5/168
CPCA61B5/1486A61B5/055A61K9/0021A61B5/150022A61B5/150969A61B5/150984A61B5/41A61M2037/0046A61M2037/0061A61P35/00A61K31/728A61K31/734A61K9/5161A61K39/3955A61K2039/585A61K2039/54A61M5/158A61M5/168C07K16/2803C07K16/2896
Inventor 顾臻汪超叶彥奇
Owner NORTH CAROLINA STATE UNIV
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