A kind of dexamethasone acetate oral patch and preparation method thereof
A technology of dexamethasone acetate and oral patch, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of uneven mixing of drug-loaded particles and sustained-release materials The uniformity of the preparation content and the existence of problems such as iron filings falling off the machine have achieved the effects of stable and controllable quality, improved operational safety, and extended service life
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Embodiment 1
[0069] Embodiment 1: dexamethasone acetate oral adhesive tablet (900,000 pieces) and preparation method thereof
[0070] 900,000 dexamethasone acetate oral adhesive tablets (specification: each tablet weighs 35mg, and each tablet contains 0.1mg of dexamethasone acetate) are prescribed as follows:
[0071]
[0072] Prepared by:
[0073] 1) Preparation of drug-loaded particles
[0074] a. Dissolution of raw materials: add 90g of dexamethasone acetate to 2500ml of absolute ethanol, put it in a water bath at 50-60°C with constant temperature and stir to dissolve, take it out after complete dissolution, let it cool to room temperature, and obtain the solution of dexamethasone acetate in absolute ethanol, which is ready for use .
[0075] B, granulation: dextrin 20kg, carbomer 0.57kg (5%) put in the high-speed mixer, add 75-80% (v / v) ethanol aqueous solution 3500ml and stir, add the described dexamethasone acetate that step a obtains Anhydrous ethanol solution, mix evenly, dis...
Embodiment 2
[0086] Embodiment 2: dexamethasone acetate oral adhesive tablet (900,000 pieces) and preparation method thereof
[0087] 900,000 dexamethasone acetate oral adhesive tablets (specification: each tablet weighs 38mg, and each tablet contains 02mg of dexamethasone acetate) are prescribed as follows:
[0088]
[0089] Prepared by:
[0090] 1) Preparation of drug-loaded particles
[0091] a. Dissolution of raw material medicine: add 180g dexamethasone acetate to 4000ml absolute ethanol, put it in a water bath at 50-60°C with constant temperature and stir to dissolve, take it out after complete dissolution, let it cool to room temperature, and obtain dexamethasone acetate absolute ethanol solution, set aside .
[0092] B, granulation: dextrin 33kg, carbomer 0.225kg (5%) put in the high-speed mixer, add 75-80% ethanol aqueous solution 2500ml and stir, add the described dexamethasone acetate dehydrated alcohol solution that step a obtains, Mix evenly, discharge according to the c...
Embodiment 3
[0103] Embodiment 3: dexamethasone acetate oral adhesive tablet (900,000 pieces) and preparation method thereof
[0104] 900,000 dexamethasone acetate oral adhesive tablets (specification: each tablet weighs 50 mg, each tablet contains 0.3 mg of dexamethasone acetate) are prescribed as follows:
[0105]
[0106] Prepared by:
[0107] 1) Preparation of drug-loaded particles
[0108] a, raw material drug dissolution: add 280.8g dexamethasone acetate to 4500ml dehydrated ethanol, put in 50-60 ℃ water bath constant temperature and stir to dissolve, take out after completely dissolving, let cool to room temperature, obtain dexamethasone acetate dehydrated alcohol solution, spare.
[0109] B, granulation: dextrin 33kg, carbomer 0.57kg (5%) put in the high-speed mixer, add 75-80% (v / v) ethanol aqueous solution 3500ml to stir, add the described dexamethasone acetate that step a obtains Anhydrous ethanol solution, mix evenly, discharge depending on the condition of the soft mater...
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