Application of terazosin in medicine for treating radioactive cognitive dysfunction

A cognitive dysfunction, terazosin technology, applied in the field of medicine, can solve problems such as brain tissue damage that cannot be avoided

Active Publication Date: 2019-01-11
GENERAL HOSPITAL OF NUCLEAR IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complexity of the anatomical structure of the brain, radiation therapy is one of the main treatment methods for head and neck malignant tumors, primary brain tumors and brain metastases. damage

Method used

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  • Application of terazosin in medicine for treating radioactive cognitive dysfunction
  • Application of terazosin in medicine for treating radioactive cognitive dysfunction
  • Application of terazosin in medicine for treating radioactive cognitive dysfunction

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Embodiment Construction

[0017] As we all know, neurons in the brain are a type of cells with extremely active physiological activities, and their normal operation requires a lot of energy. Therefore, the metabolic function of mitochondria is extremely important. At the same time, there are also literatures showing that terazosin affects the two genes of Pink1 and Parkin, participates in the renewal and metabolism of mitochondria, reduces the decline of neuron function and cell death, and has a therapeutic effect on family hereditary Parkinson's disease. At the same time, cell apoptosis and energy metabolism disorder are also important mechanisms of cognitive impairment caused by radiotherapy.

[0018] The technical solutions of the present invention will be described in detail below in conjunction with the examples. In order to make the above-mentioned purpose of the present invention more obvious and understandable, the specific implementation modes of the present invention will be described in detai...

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Abstract

The invention provides an application of terazosin in a medicine for treating radioactive cognitive dysfunction. The terazosin is a pharmaceutical salt formed with terazosin as an active ingredient ora solvate thereof. The invention has the beneficial effects that whether the terazosin component can improve cognitive function damage and hippocampal neuron damage caused by whole brain irradiationis observed through experiments, and the terazosin component has certain neuroprotective effect in the occurrence and development process of radiation cognitive function damage.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an application of terazosin in medicine for treating radioactive cognitive dysfunction. Background technique [0002] Terazosin (Terazosin) is usually used clinically as its hydrochloride, and the specifications of tablets or capsules on the market include 1 mg, 2 mg and 5 mg. Terazosin hydrochloride can be used for the treatment of benign prostatic hyperplasia and also for the treatment of hypertension, either alone or in combination with other antihypertensive drugs such as diuretics or α1-adrenergic blockers. According to the existing clinical indications, the daily dosage of terazosin for adults usually ranges from 1 to 10 mg. Terazosin is used for the treatment of benign prostatic hyperplasia (BPH). The relief of symptoms of benign prostatic hyperplasia and the improvement of urine flow rate are related to the smooth muscle relaxation caused by blockade of α1-a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61P25/28
CPCA61K31/517A61P25/28
Inventor 张力元马佳艳朱雪婷杨红英
Owner GENERAL HOSPITAL OF NUCLEAR IND
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