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An auxiliary evaluation system and method for prognosis and chemotherapy benefit of gastric cancer based on enhanced CT imaging omics

A CT imaging and radiomics technology, applied in computer tomography scanners, echo tomography and other directions, to achieve the effect of mature system, simple operation process and objective and accurate results

Inactive Publication Date: 2019-01-25
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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Problems solved by technology

However, medical imaging still has untapped valuable information about patient prognosis and chemotherapy response

Method used

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  • An auxiliary evaluation system and method for prognosis and chemotherapy benefit of gastric cancer based on enhanced CT imaging omics
  • An auxiliary evaluation system and method for prognosis and chemotherapy benefit of gastric cancer based on enhanced CT imaging omics
  • An auxiliary evaluation system and method for prognosis and chemotherapy benefit of gastric cancer based on enhanced CT imaging omics

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Embodiment Construction

[0025] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific examples.

[0026] The enhanced CT image of gastric cancer used in the present invention is collected by the following enhanced CT image equipment: 256-MDCTscanner Brilliance iCT, Philips Healthcare, Cleveland, OH, USA; 64-sectionLightSpeed ​​VCT, GE Medical Systems, Milwaukee, Wis; and GE Lightspeed 16, GE Healthcare Milwaukee, WI.

[0027]First, computer software Mazda4.6 was used to preprocess the enhanced CT images of gastric cancer, and the portal venous phase image with the largest gastric cancer lesion area was selected, and the region of interest (all gastric cancer lesion areas) was outlined on it by two experienced pathologists. Automatically extract the image features of the region of interest; 269 feature data such as texture features and morphological features are extracted...

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Abstract

The present invention relates to an auxiliary evaluation system and method for prognosis and chemotherapy benefit of gastric cancer based on enhanced CT imaging omics. A system and method of that present invention include extracting 19 image texture and morphological characteristic data of gastric cancer focus areas on enhanced CT portal vein phase images of gastric cancer objects, calculating gastric cancer imaging omics score GC Rad-score of each object, and extracting the image texture and morphological characteristic data of the gastric cancer focus areas on the enhanced CT portal vein phase images of the gastric cancer objects. Score, according to the score, predicts the prognosis and chemotherapy benefit after tumor resection and provides credible predictive and analytical results for specific individuals. The system and method of the invention are based on GC Rad-score score can be used to evaluate the prognosis and chemotherapy benefit after gastric cancer surgery. The procedure is simple, intuitive and easy to repeat. The system and method of the invention can evaluate the postoperative prognosis and chemotherapy benefit of gastric cancer, and better assist doctors to formulate treatment and follow-up plan.

Description

technical field [0001] The present invention relates to the assessment of the prognosis of gastric cancer and the benefit of chemotherapy, in particular to an auxiliary assessment system and method for the prognosis of gastric cancer and the benefit of chemotherapy based on enhanced CT influencing omics. Background technique [0002] Gastric cancer (GC) is one of the most common malignant tumors in the world. In China alone in 2015, there were 679,000 new gastric cancer patients and 498,000 gastric cancer deaths, which seriously aggravated the global disease burden, especially in China. Gastric cancer is prone to metastasis and insensitive to chemotherapy, which are important reasons for its poor prognosis. Effectively predicting the postoperative prognosis and chemotherapy benefits of patients with gastric cancer will enable the selection of appropriate treatment groups and methods, and provide strong support for effective diagnosis and treatment. The clinical staging of g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03
CPCA61B6/032
Inventor 李国新江玉明黄伟才韩震
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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