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Method for preparing oyster calcium carbonate granules

A technology of oyster calcium carbonate and granules, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, active ingredients of aluminum/calcium/magnesium, etc. It can solve the problems of long production cycle, uneven mixing of granules, and high cost, and achieve labor efficiency. Low strength, good solubility, and high yield

Active Publication Date: 2019-01-25
CHONGQING PHARSCIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] CN106943427A discloses a calcium carbonate granule composition and a preparation method thereof to solve the problems that existing calcium carbonate preparations easily increase gastrointestinal adverse reactions and poor absorption
[0011] There are many technical problems in the above preparation method, such as uneven particle mixing, low yield of finished products, long production cycle, high cost, etc.

Method used

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  • Method for preparing oyster calcium carbonate granules
  • Method for preparing oyster calcium carbonate granules
  • Method for preparing oyster calcium carbonate granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Oyster calcium carbonate granule prescription (parts by weight):

[0023]

[0024] Preparation Process:

[0025] 1) Tartrazine is dissolved in 30% ethanol solution of 4% granulation amount to obtain 30% tartrazine

[0026] weak;

[0027] 2) Grind oyster calcium carbonate, sucrose powder, and citric acid through a 100-mesh sieve, then stir in a wet granulator for 100 seconds, then add the ethanol solution in step 1) into the wet granulator while stirring at a low speed , stirring and cutting for 100s;

[0028] 3) Put the cut granules into a one-step granulator for granulation, control the air inlet temperature at 50-60°C, and spray 30% ethanol solution into the granules to meet the requirements (that is, the amount of fine powder passing through 80 mesh does not exceed 5%) , and then dry for 8 minutes;

[0029] 4) Sieve the dried granules, sieve the coarse granules, put all the granules into the mixer, spray the atomized essence at a spray rate of 80g / min, mix for...

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Abstract

The invention discloses a preparation method of oyster calcium carbonate granules, which comprises stirring oyster calcium carbonate, sucrose powder and citric acid in a wet granulator, adding 20-30%ethanol solution is addd into a wet granulator to be stirred and cut to be granulate, and then is put into a one-step granulator to be resprayed with 20-30% ethanol solution to granule, making 80 meshfine powder quantity not exceed 5%, drying 5-10 min, sieve, spraying the atomize essence at an appropriate spray rate, mixing for 30 min, and finally packaging.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation method of oyster calcium carbonate granules. Background technique [0002] Calcium is one of the important elements of the human body and has very important physiological and biochemical functions. The content of calcium in the human body accounts for 1.5-2% of the total body weight, of which bones and teeth account for about 99%. Body fluids and soft tissues make up 1%. Calcium is not only the main substance that constitutes bones, but also participates in the metabolism of bones, and is necessary to maintain nerve and muscle functions. It can also regulate the secretion and storage of neurotransmitters and hormones, the uptake and utilization of amino acids, and the absorption of vitamin B12. The important mechanism for the living cells of the human body to obtain energy is the transmembrane movement of calcium. The calcium content of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/10A61K9/16A61K47/26A61K47/12A61P3/14A61P19/10
CPCA61K9/1617A61K9/1623A61K33/10A61P3/14A61P19/10
Inventor 聂铭叶兆军周帮建黄介江桂清杭永禄邓林唐秀春
Owner CHONGQING PHARSCIN PHARM CO LTD
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