Preservative composition for antisepsis of enzyme creatinine agent

Abstract

The invention discloses a preservative composition for the antisepsis of an enzyme creatinine agent, wherein the preservative composition comprises the following raw materials by weight: 1-3 parts ofa stabilizer, 0.4-1.3 parts of a preservative, 1-2 parts of a surfactant, 1-1.3 parts of a washing agent, 1-2 parts of ascorbate oxidase creatininase, 0.5-1.5 parts of sarcosine oxidase, 2-3 parts ofa buffer liquid, 2-3 parts of peroxidase, 3-5 parts of aminoantipyrine, and 2-4 parts of potassium ferrocyanide. The method specifically comprises: 1, respectively placing 3 parts of thiosulfate, 3 parts of thiocyanate, 3 parts of maleic acid, and 3 parts of sodium dialkyl sulfate in a mixing device, and uniformly stirring by a stirring rod. The invention relates to the technical field of creatinine. According to the present invention, with the preservative composition, the enzyme creatinine reagent can be prevented from being corroded by other corrosive chemical substances during the quantitative determination of the creatinine in human serum, plasma (lithium heparin and K2EDTA) and urine by the ADVIA biochemical analysis system so as not to affect the determination results.

Description

technical field [0001] The invention relates to the technical field of creatinine, in particular to a preservative composition used for enzymatic creatinine reagent preservation. Background technique [0002] Creatinine is a polar organic nitrogen compound with a relatively small molecular weight. The sources of serum creatinine are divided into exogenous and endogenous sources. Exogenous creatinine is the product of meat food metabolism in the body; endogenous creatinine is the product of muscle tissue metabolism in the body. When the intake of meat food is stable and the body's muscle metabolism is basically unchanged, the production of creatinine is constant. Creatinine can be filtered through the glomerulus and is rarely absorbed in the renal tubules. Almost all creatinine produced in the body is excreted with urine every day, and is generally not affected by urine output. Clinically, blood creatinine concentration is used to reflect renal function such as renal damage...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a preservative composition for enzymatic creatinine reagent preservation, which solves the problem that the enzymatic creatinine reagent lacks antiseptic function and is easily corroded by some other chemical substances when it is tested again , and then affect the measurement results