Efficient rack special for sampling system with automatic release rate

Abstract

The invention discloses an efficient rack special for a sampling system with an automatic release rate. The efficient rack is characterized in comprising a base, a vertical movement mechanism, a horizontal movement mechanism, a sampling bracket, an inner pipe placement frame and a solvent outer pipe placement plate. By use of the efficient rack, a vertical movement way is adopted to simulate intestinal tract movement, the inner pipe adopts a vertical movement way in the solvent outer pipe, so that the solvent outer pipe simulates the intestine and stomach environment in the human body, the inner pipe vertically moves in the solvent outer pipe, and dissolution power is high. In addition, the above movement way is more similar to an intestine and stomach movement way, the vertical movement way is more proper to simulate the intestine and stomach movement environment, and an experiment effect is good.

Description

technical field [0001] The invention belongs to the technical field of medical experiment equipment application, in particular to a high-efficiency rack dedicated to an automatic release rate sampling system. Background technique [0002] In order to produce a desired pharmacological effect, the drug must be made available in the body at an appropriate concentration at its site of action. This effectiveness is influenced by a variety of factors including: the amount of drug administered, the rate of drug absorption, distribution (binding or localization) in tissues, drug metabolism, and elimination from the body. [0003] As an inspection method for drug properties, dissolution testing plays an important role in the quality consistency evaluation of generic drug preparations and changes after approval. The United States Pharmacopoeia divides drug dissolution release devices into 1-7 methods, of which the third method is the reciprocating cylinder method, which is used for t...

AI Technical Summary

Problems solved by technology

[0007] Therefore, when performing dissolution experiments, it is often necessary to fully simulate various parts of the stomach and intestinal tract. This process requires the use of multiple or even multiple solvent outer tubes to simulate the environment. Most of them use the same solvent outer tube. When changing the environment of the drug, it is necessary to take out the drug basket and replace the solvent outer tube. In this way, there will be errors in the experimental time, which will easily lead to inaccurate experimental data.

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