Preparation of a non-toxic hair dye imitating melanin and hair dyeing method

A technology of hair dye and melanin, which is applied in the direction of medical preparations containing active ingredients, hair care, pharmaceutical formulas, etc., can solve problems such as restrictions on commercial promotion and use, insufficient diversity of hair dyeing colors, and unsatisfactory dyeing effects, etc., to achieve High stability of hair dyeing effect, beneficial to environmental protection, and easy to operate

Active Publication Date: 2021-06-29
SOUTHWEST MEDICAL UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although semi-permanent hair dyes can color hair under relatively mild pH conditions, they limit the diffusion of colorants, resulting in insufficient dye loading, and the color is washed out after a few washes
While using graphene or other natural pigments for hair dyeing, on the one hand, their biological safety still has a relatively large hidden danger; Ideal, limiting its commercial promotion and use

Method used

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  • Preparation of a non-toxic hair dye imitating melanin and hair dyeing method
  • Preparation of a non-toxic hair dye imitating melanin and hair dyeing method
  • Preparation of a non-toxic hair dye imitating melanin and hair dyeing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: see figure 1 , a preparation method of imitating melanin nontoxic hair dye, the hair dye includes A agent, B agent and C agent, and the A agent, B agent and C agent are prepared according to the following steps:

[0025] Step 1. Preparation of intermediate reaction liquid: under low temperature (0-4°C), dissolve the amphiphilic block copolymer with gel-solution temperature-sensitive properties in a solution with a concentration of 10-50mM and a pH of 4-4°C. In the acetic acid-sodium acetate buffer solution of 6, be made into intermediate reaction liquid; The mass concentration of copolymer in the prepared intermediate reaction liquid is (15~30)% (w / v); Described amphiphilic block copolymer Pluronic, or carbomer, that is, acrylic resin, or chitosan, that is, polyglucosamine (1-4)-2-amino-B-D glucose, or agar. Specifically, Pluronic F68 (trade name: Poloxamer 188), Pluronic F87 (trade name: Poloxamer 237), Pluronic F108 (trade name: Poloxamer 338) or Pluron...

Embodiment 2

[0030] Step 1. First prepare 50mM acetic acid-sodium acetate buffer solution with pH=5, then weigh 25g of carbomer, add 100ml of acetic acid-sodium acetate buffer solution, and obtain Pluronic with a mass concentration of 25%. - Acetic acid-sodium acetate buffer.

[0031] Step 2. Preparation of Agent A: Weigh 1g of dopamine, add it into the 100ml pluronic-acetic acid-sodium acetate buffer solution prepared in Step 1, stir to dissolve evenly, and then obtain Agent A.

[0032] Step 3. Preparation of agent B: Weigh 5g of sodium periodate and add it to the 100ml pluronic-acetic acid-sodium acetate buffer solution prepared in step 1 to prepare agent B.

[0033]Step 4. Prepare agent C: according to the hair color requirements, quantitatively weigh 2g of copper sulfate pentahydrate or ferrous chloride tetrahydrate or ferric chloride, and add 100ml of pluronic-acetic acid-sodium acetate buffer solution prepared in step 1 , stir evenly to dissolve it, and its mass concentration is 20m...

Embodiment 3

[0035] Step 1. Preparation of intermediate reaction solution: Take 10g of Pluronic F127, put it in a beaker, add it to 40ml of acetic acid-sodium acetate buffer solution (50mM, pH=5), and put it in an environment of 0-4°C until it dissolves completely , forming an intermediate reaction solution.

[0036] Step 2. Preparation of agent A: Weigh 0.33g of dopamine, add it into 20ml of intermediate reaction solution, and stir to dissolve it evenly.

[0037] Step 3, preparation of agent B: take 1.1 g of sodium periodate, add it to 20 ml of the intermediate reaction solution, and dissolve it completely.

[0038] Step 4. Hair dyeing: at room temperature (10-20°C), mix agent A and agent B uniformly at a ratio of 10:1 to obtain a hair dye, and then raise the temperature to 25-30°C to make the hair dye in a gel state. Then apply it evenly on the hair to be dyed immediately, wait for 1 hour, rinse the hair with clean water, and get the effect of black hair.

[0039] see figure 2 and ...

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Abstract

The invention discloses a method for preparing a non-toxic imitation melanin hair dye and a hair dyeing method; a method for preparing a non-toxic imitation melanin hair dye, which is characterized in that: the hair dye includes agent A and agent B, and the agent A and Agent B is prepared according to the following steps: 1. Under low temperature (0-4°C), dissolve the amphiphilic block copolymer with gel-solution temperature-sensitive properties in a solution with a concentration of 10-50mM and a pH of 4-4°C. 6 in the acetic acid-sodium acetate buffer solution to prepare an intermediate reaction solution; the mass concentration of the copolymer in the prepared intermediate reaction solution is (15~30)% (w / v); two, dopamine is uniformly dissolved in step one In the intermediate reaction liquid prepared, obtain A agent; The mass concentration of dopamine in A agent is (0.1~15) mg / ml; Three, the sodium periodate is uniformly dissolved in the intermediate reaction liquid prepared in step 1, obtains B agent; the mass concentration of sodium periodate in agent B is (30-60) mg / ml; the present invention can be widely used in various groups of people and in the production of wigs.

Description

technical field [0001] The invention relates to a hair dye, in particular to a preparation of a melanin-like nontoxic hair dye and a hair dyeing method. Background technique [0002] Hair dyes have a long history of use. The main dyes used in traditional commercial hair dye formulations can be broken down into three main categories: temporary, semi-permanent, and permanent. Permanent hair dyes use a base, such as ammonia, to swell and open the cuticle on the surface of the hair. Enables aromatic amine and / or phenol-based colorants (such as p-phenylenediamine and p-aminophenol) to penetrate deep into the hair. Oxidizing agents such as hydrogen peroxide are used to bleach natural melanin and initiate reactions between the pigments to synthesize the final dye compound. Semi-permanent hair dyes can treat hair at a weak alkaline or near neutral pH, avoiding the opening of the cuticle, and dye molecules with relatively small molecular weights penetrate into the epidermis of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/41A61K8/20A61K8/36A61K8/19A61K8/86A61K8/81A61K8/04A61Q5/10
CPCA61K8/042A61K8/19A61K8/20A61K8/36A61K8/41A61K8/8147A61K8/86A61K2800/4324A61Q5/10
Inventor 付琦峰邱艳尹红刚高蝶张开莲易高圯
Owner SOUTHWEST MEDICAL UNIVERISTY
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