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Quality detecting method of medicine composition for treating obsessed feeling

A quality inspection method and drug technology, applied in the field of medical invention, can solve the problems of lack of quality, inaccurate identification, and insufficient color development of Shumian capsules, etc., and achieve the effect of increasing thin-layer identification and optimizing the identification method

Active Publication Date: 2019-03-01
贵州大隆药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The detection method of Shumian Capsules is disclosed in the quality standard of State Drug Administration National Drug Standard WS3-773 (Z-137)-2001Z Shumian Capsules. The inventor finds through research that the existing quality standard of Shumian Capsules In the inspection of the main medicinal ingredient Ziziziren in the preparation, only the jujube seed saponin A was identified by TLC, which was not enough to control the quality of Shumian Capsules. The preparation of the test solution is not ideal, resulting in the color development is not clear enough, and the identification is not accurate enough; the lack of quality control of the active ingredients Bombyx mori and Rush, it is difficult to fully control the quality of Shumian Capsules

Method used

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  • Quality detecting method of medicine composition for treating obsessed feeling
  • Quality detecting method of medicine composition for treating obsessed feeling
  • Quality detecting method of medicine composition for treating obsessed feeling

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 【Properties】This product is a capsule, the content is yellow to brown powder; slightly gas, bitter taste.

[0040] 【identification】

[0041] TLC identification

[0042] Preparation of the test solution: Take 4.5g of the content of the pharmaceutical preparation, add 20ml of ethanol:methanol:ethyl acetate solution with a volume ratio of 0.8:0.8:1, ultrasonicate at 60°C for 35 minutes, filter, and place the filtrate in a water bath Evaporate to dryness, add 5ml of water to the residue to dissolve, shake and extract 2 times with water-saturated n-butanol, 10ml each time, combine the n-butanol solution, wash 2 times with 5% sodium bicarbonate, 10ml each time, discard the lotion , the n-butanol solution was evaporated to dryness on a water bath, and the residue was dissolved in 1 ml of methanol, which was used as the test solution;

[0043] Preparation of the reference medicinal material solution: take 1.8g of the reference medicinal material of Bupleurum chinensis, and pr...

Embodiment 2

[0070] 【Properties】This product is a capsule, the content is yellow to brown powder; slightly gas, bitter taste.

[0071] 【Identification】TLC identification

[0072] Preparation of the test solution: Take 5.5g of the content of the pharmaceutical preparation, add 30ml of ethanol:methanol:ethyl acetate solution with a volume ratio of 1:1:1.5, ultrasonicate at 60°C for 35 minutes, filter, and place the filtrate in a water bath Evaporate to dryness, add 10ml of water to the residue to dissolve, shake and extract twice with water-saturated n-butanol, 15ml each time, combine the n-butanol solution, wash twice with 10% sodium bicarbonate, 20ml each time, discard the washed solution, the n-butanol solution was evaporated to dryness on a water bath, and the residue was dissolved by adding 3ml of methanol, which was used as the test solution;

[0073] Preparation of the reference medicinal material solution: take 2.2g of the reference medicinal material of Bupleurum chinensis, and pre...

Embodiment 3

[0100] 【Properties】This product is a capsule, the content is yellow to brown powder; slightly gas, bitter taste.

[0101] 【identification】

[0102] TLC identification

[0103] Preparation of the test solution: Take 5g of the content of the pharmaceutical preparation, add 30ml of ethanol:methanol:ethyl acetate solution with a volume ratio of 1:1:1.5, ultrasonicate at 60°C for 35 minutes, filter, and place the filtrate on a water bath Evaporate to dryness, add 10ml of water to the residue to dissolve, shake and extract 3 times with water-saturated n-butanol, 15ml each time, combine the n-butanol solution, wash 3 times with 5% sodium bicarbonate, 20ml each time, discard the lotion , the n-butanol solution was evaporated to dryness on a water bath, and the residue was dissolved in 1 ml of methanol, which was used as the test solution;

[0104] Preparation of the reference medicinal material solution: take 2 g of the reference medicinal material of Bupleurum chinensis, and prepar...

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Abstract

The invention relates to a quality detecting method of a medicine composition for treating obsessed feeling. The medicine composition is prepared from semen ziziphi spinosae, radix bupleuri, white paeony roots, flos albizziae, cortex albiziae, bombyx batryticatus, cicada slough and junci medulla. The quality detecting method comprises the steps of distinguishing the active ingredients of radix bupleuri, flos albizziae, cortex albiziae, bombyx batryticatus and junci medulla, and determining the content of paeoniflorin in white paeony root, jujuboside A in semen ziziphi spinosae and spinosin. The jujuboside in semen ziziphi spinosae and flavonoid ingredient spinosin have important sedative and hypnotic effects; a basis is provided for evaluating the quality of semen ziziphi spinosae. The medicine quality is comprehensively and effectively controlled; an efficient, strict and reliable quality detecting method is made for ensuring the medicine quality; the accuracy is high; the stability is high; the sample treatment time is saved; the method can be effectively used for the quality detection on the medicine composition for treating obsessed feeling.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a quality detection method for a medicinal composition for treating restlessness. Background technique [0002] The preparation of the medicinal composition for treating restlessness is Shumian Capsules, which is composed of Suanzaoren, Bupleurum, Radix Paeoniae Albizia, Albizia Julibrissin, Cortex Albizia Albizia, Silkworm, Cicada Slough, and Rush. Mature seeds have the effects of nourishing the liver, calming the heart, and promoting body fluid. They are mainly used for restlessness and insomnia, palpitations and dreaminess, body deficiency and hyperhidrosis, and thirst for fluid wounds. Jujube seed contains flavonoid glycosides, triterpenes, saponins, and organic acids. Sour jujube saponin A and spinosin are important active ingredients, which can effectively calm the nerves and have a significant effect on insomniacs; Bupleurum: the dried roots of Bupleurum bupleuri and Bupl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90
CPCG01N30/02G01N30/90
Inventor 刘念宁徐卫东聂开品
Owner 贵州大隆药业有限责任公司
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