Methods for inhibiting stenosis, obstruction, or calcification of stented heart valve or bioprosthesis
A technology for heart valves and biological prostheses, applied in the direction of heart valves, prostheses, drug delivery, etc., can solve problems such as failure
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[0070] Coating a bioprosthetic heart valve with a coating composition comprising an eNOS activator, atorvastatin, an antiproliferative agent, paclitaxel; an extracellular production inhibitor, an anti-farnesyltransferase inhibitor; And osteogenesis inhibitors, bisphosphonate drugs. A bioprosthetic heart valve was implanted in a 75-year-old female patient. The patient was also receiving lipid-lowering therapy consisting of atorvastatin 80 mg orally per day and a PCSK9 inhibitor in the amount of 75 mg subcutaneously once a month to reduce her LDL cholesterol levels from 350 mg / ml to 80 mg / ml . On review of her echocardiogram, the bioprosthetic leaflets and stent had normal hemodynamics over a 25-year period, with a mean gradient of 10 mmHg and an aortic valve area of 2.0 cm2. The bioprosthetic valve leaflets and scaffold did not show any signs of calcification, as diagnosed by computed tomography and echocardiography.
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