Methods for inhibiting stenosis, obstruction, or calcification of stented heart valve or bioprosthesis

A technology for heart valves and biological prostheses, applied in the direction of heart valves, prostheses, drug delivery, etc., can solve problems such as failure

Inactive Publication Date: 2019-03-15
CONCIEVALVE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As mentioned above, this technique was not successful

Method used

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  • Methods for inhibiting stenosis, obstruction, or calcification of stented heart valve or bioprosthesis
  • Methods for inhibiting stenosis, obstruction, or calcification of stented heart valve or bioprosthesis
  • Methods for inhibiting stenosis, obstruction, or calcification of stented heart valve or bioprosthesis

Examples

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Embodiment I

[0070] Coating a bioprosthetic heart valve with a coating composition comprising an eNOS activator, atorvastatin, an antiproliferative agent, paclitaxel; an extracellular production inhibitor, an anti-farnesyltransferase inhibitor; And osteogenesis inhibitors, bisphosphonate drugs. A bioprosthetic heart valve was implanted in a 75-year-old female patient. The patient was also receiving lipid-lowering therapy consisting of atorvastatin 80 mg orally per day and a PCSK9 inhibitor in the amount of 75 mg subcutaneously once a month to reduce her LDL cholesterol levels from 350 mg / ml to 80 mg / ml . On review of her echocardiogram, the bioprosthetic leaflets and stent had normal hemodynamics over a 25-year period, with a mean gradient of 10 mmHg and an aortic valve area of ​​2.0 cm2. The bioprosthetic valve leaflets and scaffold did not show any signs of calcification, as diagnosed by computed tomography and echocardiography.

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Abstract

Methods for inhibiting stenosis, obstruction and / or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including oneor more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis,obstruction and / or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to thebioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.

Description

[0001] Cross references to related patent applications [0002] This application is a continuation-in-part of pending U.S. Application Serial No. 15 / 193,208, filed June 27, 2016, which is a divisional of U.S. Application Serial No. 14 / 263,438, filed April 28, 2014, This U.S. application is a continuation-in-part of now-abandoned U.S. Application Serial No. 13 / 656,925, filed October 22, 2012; and this application is a pending U.S. Application Serial No. 14 / 687,479, filed April 15, 2015 14 / 263,438 filed April 28, 2014, which was filed on October 22, 2012 and has been A continuation-in-part of abandoned U.S. application Serial No. 13 / 656,925; and this application is a continuation-in-part of pending U.S. 371(c) national phase application of priority to International Patent Application Serial No. PCT / US2014 / 061745 filed on 22 October 2014; the entire contents of these patents are incorporated herein by reference. technical field [0003] The present invention relates to methods...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/24A61K45/06A61L27/28
CPCA61F2/2418A61F2250/0067A61L27/3625A61L27/54A61L2300/258A61L2300/416A61L2400/02A61L2430/20A61F2/2412A61K9/0024A61K31/337A61K31/40A61L31/14A61L31/16A61L2300/204A61L2300/21A61L2300/606
Inventor 纳里尼·M·拉贾曼楠
Owner CONCIEVALVE
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