A fully human anti-bcma chimeric antigen receptor and its application

A chimeric antigen receptor, fully human technology, applied in the field of tumor cell immunotherapy, can solve the problems of unpredictable treatment effect and unstable treatment effect.
CN109485733BActive Publication Date: 2020-04-24GUANGZHOU BIO GENE TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGZHOU BIO GENE TECH CO LTD
Publication Date
2020-04-24

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Abstract

The invention relates to a fully human anti-BCMA (B Cell Maturation Antigen) chimeric antigen receptor and application thereof. The chimeric antigen receptor comprises an extracellular domain, a membrane spanning domain and at least one intracellular domain capable of binding antigens, wherein the extracellular domain is an anti-BCMA single domain antibody; and the fully human anti-BCMA antibody comprises a heavy chain variable region and a light chain variable region having specific sequences. The chimeric antigen receptor disclosed by the invention has low immunogenicity, small rejection reaction and high safety, the solid tumor foci can be effectively reduced, and the tumor treatment effect is effectively improved.
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Description

technical field

[0001] The present invention relates to the field of tumor cell immunotherapy, in particular to a fully human anti-BCMA chimeric antigen receptor and its application, specifically the fully human chimeric antigen receptor T (CAR-T) cell technology construction method and its application in anti-tumor therapy. Background technique

[0002] With the development of tumor immunology theory and clinical technology, chimeric antigen receptor T-cell immunotherapy (CAR-T) has become one of the most promising tumor immunotherapy. Generally, a chimeric antigen receptor CAR consists of a tumor-associated antigen-binding region, an extracellular hinge region, a transmembrane region, and an intracellular signal transduction region. Usually, CAR contains the single chain fragment variable region (Single chain fragment variable, scFv) of the antibody or the binding domain specific to the tumor associated antigen (tumor associated antigen, TAA), which communicates with the ...

Claims

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