41results about How to "Effective treatment options" patented technology

The invention discloses an intracranial aneurysm rupture risk assessment method and system. The method is applied to the intracranial aneurysm rupture risk assessment method and includes steps: creating a three-dimensional model comprising a parent artery and an aneurysm on the parent artery according to intracranial image data; determining target morphological parameters of a virtual parent artery and a virtual aneurysm on the basis of the three-dimensional model; determining target hemodynamic parameters of the virtual parent artery and the virtual aneurysm on the basis of the three-dimensional model; performing operation on the target morphological parameters, the target hemodynamic parameters and target clinical parameters on the basis of a pre-trained machine learning model to obtaina virtual aneurysm assessment result for assessing aneurysm rupture risks. Therefore, by implementation of the method and the system, accuracy in aneurysm rupture risk assessment can be improved through automatic comprehensive analysis of intracranial aneurysm rupture risks according to clinical parameters, morphological parameters and hemodynamic parameters of intracranial aneurysms of patients.

The invention relates to a chimeric antigen receptor targeting BCMA, which comprises an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, wherein the extracellular domain is an anti-BCMA single domain antibody; wherein the amino acid sequence of the anti-BCMA single domain antibody is selected from: (a) an amino acid sequence as shown in SEQ ID NO. 1; or (b) a variant which is formed by substitution, addition or deletion of one or more amino acids in the amino acid sequence shown in SEQ ID NO. 1 and which is capable of specifically binding to the chimeric antigen receptor and has a function of binding to BCMA and inducing T cell signaling conduction. The chimeric antigen receptor has smaller clinical side effects and highersafety, can effectively reduce solid tumor focus and effectively improve the treatment effect of tumors.

The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.

The invention relates to a fully human anti-BCMA (B Cell Maturation Antigen) chimeric antigen receptor and application thereof. The chimeric antigen receptor comprises an extracellular domain, a membrane spanning domain and at least one intracellular domain capable of binding antigens, wherein the extracellular domain is an anti-BCMA single domain antibody; and the fully human anti-BCMA antibody comprises a heavy chain variable region and a light chain variable region having specific sequences. The chimeric antigen receptor disclosed by the invention has low immunogenicity, small rejection reaction and high safety, the solid tumor foci can be effectively reduced, and the tumor treatment effect is effectively improved.

The invention discloses a method and device for measuring morphological parameters of an intracranial aneurysm image. The method comprises constructing a three-dimensional model comprising a parent artery and an aneurysm on the parent artery according to intracranial image data, wherein the three-dimensional model comprises a virtual parent artery matched with the parent artery and a virtual aneurysm matched with the aneurysm; determining an aneurysmal neck plane of the virtual aneurysm based on the three-dimensional model and determining a target morphological parameter based on the three-dimensional model and the aneurysmal neck plane, wherein the target morphological parameter at least includes the morphological parameter of the virtual aneurysm. The three-dimensional model of the intracranial image data and the aneurysmal neck plane of the virtual aneurysm included by the three-dimensional model are utilized to measure the morphological parameters of the intracranial aneurysm automatically, which can not only improve the measurement accuracy of the morphological parameters of the intracranial aneurysm but also improve the measurement speed of the morphological parameters of theintracranial aneurysm, thus providing a scientific reference for medical staff in making treatment decisions.

The realization method is part of the biology project technology field, based on sequence alignment nuclear function to forecast signal peptide and its breakpoint position. The invention adopt full sequence alignment to settle the problem that the amino acid sequence lengths are disagreement, and count the relativity between two amino acid sequences to reflect the similarity of both. The new coordinate is made by space transform, after the similarity matrix transform non-negative fix matrix; it settle the problem how make a matrix of dissatisfied non-negative fix condition into a nuclear matrix. For a new amino acid sequence, at its new characteristic space, the said method can forecast whether it is a signal peptide and estimate its breakpoint position. The said invention increase the correctness of forecast signal peptide and forecast breakpoint, so it has a great effect to understand the cause of some illness and is helpful to explore effective cure precept.

The invention provides a traditional Chinese medicine acupoint patch for treating insomnia of women in the perimenopausal period. Raw medicine materials of the traditional Chinese medicine acupoint patch include rhizoma coptidis from Sichuan of China, yolk, colla corii asini, radix rehmanniae preparata, radix paeoniae alba, fructus ligustri lucidi, bulbus lilii, ratan of polygonum multiflorum, radix polygalae, semen ziziphi spinosae, cortex albiziae, radix scutellariae, plumula nelumbinis, fructus gardeniae, herbal lophatheri, seman platycladi, light wheat, cochinchinese asparagus roots, semen coicis, common yam rhizomes, fructus lycii, rhizoma acori tatarinowii, radix glycyrrhizae preparata and cortex cinnamomi. The traditional Chinese medicine acupoint patch is remarkable in treatment effect, the effect is superior to that of an old method or an old formula, and an economical, effective and rapid treatment scheme is provided for insomniacs.

The invention relates to a prescription for treating ascites due to cirrhosis and a preparing method thereof. The prescription includes musk, radix euphorbiae kansui, earthworm and villous amomum fruit. The prescription includes 1-3 parts by weight of the musk, 0.5-2 parts by weight of the radix euphorbiae kansui, 5-15 parts by weight of the earthworm and 8-13 parts by weight of the villous amomum fruit. The method includes 1) a step of weighing medicine materials, 2) a step of cleaning and drying the medicine materials, 3) crushing the medicine materials, and 4) blending the crushed medicine materials into medicine paste. By adopting liver function improving and portal vein haemodynamic interference as breakthrough points, an umbilicus external application manner is adopted, and the holistic view and advantages of treatment based on syndrome differentiation of the traditional Chinese medicine are fully utilized to treat the ascites due to cirrhosis and portal hypertension. The prescription has characteristics of a simple and effective treatment scheme, a low cost, few adverse effects and capability of being easily accepted by patients, and being widely popularized and applied in primary hospitals. The prescription improves clinical symptoms of patients with ascites due to cirrhosis, improves liver functions, reduces portal vein pressure, and is free of obvious toxic or side effects.

The invention discloses a combined drug composition for breast cancer immunotherapy and an application of the combined drug composition. The combined drug composition comprises an SR1664 inhibitor ineffective quantity and an immunologic test point blocking antibody in effective quantity. The invention further provides a tumor immunotherapy drug combination method. The inventor finds that SR1664 can be used for resisting tumor malignant progression of PPAR gamma phosphorylation mediated with CDK5. The tumor relevant macrophage phenotype and function in tumor microenvironment can be adjusted and controlled, so that the T cellular infiltration is improved, and the immunosuppression tumor microenvironment can be further reversed. Through synergism of the SR1664 and the immunologic test pointblocking antibody, tumor restraining can be further reinforced.

The invention belongs to the field of biological medicine, and particularly relates to a circular RNA molecule, a cyclized precursor RNA molecule, a recombinant nucleic acid molecule, a recombinant expression vector, a recombinant host cell, a composition, application of the composition in targeted degradation of target protein and a method for preventing or treating diseases. The circular RNA molecule has good membrane permeability, is easy to be delivered into cells, and has efficient in-vivo protein targeted degradation activity. According to the circular RNA molecule disclosed by the invention, tumor growth inhibition is successfully realized, the in-vivo protein degradation activity of the bio-PROTACs is proved for the first time, and a positive and effective treatment scheme is provided for treatment of diseases such as tumors.

The invention belongs to the technical field of medicine, relates to novel use of PK11195, and particularly relates to the use of PK11195 or a pharmaceutically acceptable salt thereof in the preparation of a medicine/cosmetic for treating and/or preventing hyperpigmented diseases, especially the use in preparation of a medicine/cosmetic for treating and/or preventing various hereditary, ultraviolet and inflammatory factors-induced hyperpigmentation such as freckles, pregnancy spots, melasma, coffee spots and moles.

The invention discloses a medicine bottle capable of collecting medicine taking data of a patient. The medicine bottle comprises an opaque bottle cover, an opaque bottle body, a display unit, a weighing unit, an opening sensing unit, a control unit, a posture sensing unit and a wireless communication unit. The display unit is installed on the outer side wall of the bottle body. The opening sensing unit is installed at the upper portion of the inner side wall of the bottle body. The weighing unit is installed on the upper layer of the inner surface of the bottom of the bottle body. The control unit, the posture sensing unit and the wireless communication unit are all installed in the bottom of the bottle body. The display unit, the opening sensing unit, the weighing unit, the posture sensing unit and the wireless communication unit are all electrically connected with the control unit. The medicine bottle can continuously collect medicine taking time, medicine taking amounts and other data of the patient and can also transmit the data to an external wireless mobile communication device and transmit the data to a cloud side or other data centers through the external wireless mobile communication device.

The invention discloses an application of Artemisia carvifolia in the preparation of gastrointestinal disease treatment drugs, and belongs to the technical field of drugs. Artemisia carvifolia has the advantages of improvement of the symptoms of gastrointestinal diseases, lasting curative effect and no obvious untoward effects in the treatment of Helicobacter pylori infected gastrointestinal diseases, and is suitable for treating gastritis, gastric and duodenal ulcer or nausea, vomiting, abdominal pain, diarrhea and other diseases.

The invention discloses a chest X-ray display device with an adjusting mechanism. The chest X-ray display device comprises a bed board, a perspective body, a main body and a groove, wherein a liftingrod is arranged on the right side of the bed board, a flexible rod is arranged at the top of the lifting rod, the perspective body is fixed to the top end of the flexible rod, a pillow is arranged atthe top of the bed board, a clamping groove is formed in the inner side of the pillow, the left end of the bed board is connected with a wood plate, a transverse plate is arranged on the outer wall ofthe wood plate, a fixing plate is arranged at the bottom of the transverse plate, a supporting body is installed at the top end of the transverse plate, the main body is fixed to the top of the supporting body, a display screen is arranged on the inner side of the main body, and supporting columns are arranged at the bottom of the bed board. Through arrangement of the bed board, the lifting rod,the flexible rod and the perspective body, the central axis of the lifting rod coincides with the central axis of the bed board, and through the lifting effect of the lifting rod, the height of the perspective body can be adjusted, so that the device works more smoothly.

The invention provides a broad-spectrum beta-lactamase fluorescent substrate applied to a fluorescence detection method capable of detecting the drug resistance of bacteria in a single body. The structure of the broad-spectrum beta-lactamase fluorescent substrate is shown in the specification. An experiment result indicates that the fluorescent substrate C-2 provided by the invention can accurately and qualitatively detect cephalosporin resistant bacteria in different samples, can be applied to clinical or other detection fields to prepare a corresponding diagnostic reagent or diagnostic kit, and has broad application space and a high practical value.

The invention belongs to the technical field of medicines, relates to new use of J147 and particularly relates to use of the J147 or pharmaceutically acceptable salts thereof in preparation of medicines/cosmetics for treating and/or preventing hyperpigmentation diseases, particularly various pigmented skin diseases such as chloasma, hyperpigmentation after inflammation and senile freckles.

The invention relates to a compound of sulfaurea drug and statins lipid lowering drug, belonging to the pharmaceutical field. The compound contains sulfaurea drug of therapy dose or salts of the sulfaurea, statins lipid lowering drug with low therapy dose or the pharmaceutical salt and pharmaceutical carrier or excipient. The invention also relates to the purpose of the compound in preparation of drug for preventing and treating a living body ill with diabetes and lipid metabolism disorder, providing an effective therapeutic schedule for the diabetes and lipid metabolism disorder.