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41results about How to "Effective treatment options" patented technology

Intracranial aneurysm rupture risk assessment method and system

The invention discloses an intracranial aneurysm rupture risk assessment method and system. The method is applied to the intracranial aneurysm rupture risk assessment method and includes steps: creating a three-dimensional model comprising a parent artery and an aneurysm on the parent artery according to intracranial image data; determining target morphological parameters of a virtual parent artery and a virtual aneurysm on the basis of the three-dimensional model; determining target hemodynamic parameters of the virtual parent artery and the virtual aneurysm on the basis of the three-dimensional model; performing operation on the target morphological parameters, the target hemodynamic parameters and target clinical parameters on the basis of a pre-trained machine learning model to obtaina virtual aneurysm assessment result for assessing aneurysm rupture risks. Therefore, by implementation of the method and the system, accuracy in aneurysm rupture risk assessment can be improved through automatic comprehensive analysis of intracranial aneurysm rupture risks according to clinical parameters, morphological parameters and hemodynamic parameters of intracranial aneurysms of patients.
Owner:唯智医疗科技佛山有限公司

Chimeric antigen receptor targeting BCMA and application thereof

The invention relates to a chimeric antigen receptor targeting BCMA, which comprises an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, wherein the extracellular domain is an anti-BCMA single domain antibody; wherein the amino acid sequence of the anti-BCMA single domain antibody is selected from: (a) an amino acid sequence as shown in SEQ ID NO. 1; or (b) a variant which is formed by substitution, addition or deletion of one or more amino acids in the amino acid sequence shown in SEQ ID NO. 1 and which is capable of specifically binding to the chimeric antigen receptor and has a function of binding to BCMA and inducing T cell signaling conduction. The chimeric antigen receptor has smaller clinical side effects and highersafety, can effectively reduce solid tumor focus and effectively improve the treatment effect of tumors.
Owner:GUANGZHOU BIO GENE TECH CO LTD

Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse

The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.
Owner:FRED HUTCHINSON CANCER RES CENT

Fully human anti-BCMA (B Cell Maturation Antigen) chimeric antigen receptor and application thereof

The invention relates to a fully human anti-BCMA (B Cell Maturation Antigen) chimeric antigen receptor and application thereof. The chimeric antigen receptor comprises an extracellular domain, a membrane spanning domain and at least one intracellular domain capable of binding antigens, wherein the extracellular domain is an anti-BCMA single domain antibody; and the fully human anti-BCMA antibody comprises a heavy chain variable region and a light chain variable region having specific sequences. The chimeric antigen receptor disclosed by the invention has low immunogenicity, small rejection reaction and high safety, the solid tumor foci can be effectively reduced, and the tumor treatment effect is effectively improved.
Owner:GUANGZHOU BIO GENE TECH CO LTD

Method and device for measuring morphological parameters of intracranial aneurysm image

The invention discloses a method and device for measuring morphological parameters of an intracranial aneurysm image. The method comprises constructing a three-dimensional model comprising a parent artery and an aneurysm on the parent artery according to intracranial image data, wherein the three-dimensional model comprises a virtual parent artery matched with the parent artery and a virtual aneurysm matched with the aneurysm; determining an aneurysmal neck plane of the virtual aneurysm based on the three-dimensional model and determining a target morphological parameter based on the three-dimensional model and the aneurysmal neck plane, wherein the target morphological parameter at least includes the morphological parameter of the virtual aneurysm. The three-dimensional model of the intracranial image data and the aneurysmal neck plane of the virtual aneurysm included by the three-dimensional model are utilized to measure the morphological parameters of the intracranial aneurysm automatically, which can not only improve the measurement accuracy of the morphological parameters of the intracranial aneurysm but also improve the measurement speed of the morphological parameters of theintracranial aneurysm, thus providing a scientific reference for medical staff in making treatment decisions.
Owner:唯智医疗科技佛山有限公司

Combined medication combination for tumor immnuotherapy

ActiveCN106955354AInhibitory activityEnhance antigen-specific immune responseAntibody ingredientsImmunoglobulinsCD8Acyl coenzyme A
The invention provides a combined medication combination for tumor immunotherapy. The combined medication combination contains an effective dose of an acyl coenzyme A: cholesterol acyltransferase ACAT1 inhibitor and an effective dose of an immune detection point blocking antibody. The invention further provides a combined medication method for the tumor immunotherapy. By inhibiting the acyl coenzyme A: cholesterol acyltransferase ACAT1, the killing activity of CD8 T cells to tumors can be enhanced, and the acyl coenzyme A: cholesterol acyltransferase ACAT1 and the immune detection point blocking antibody can generate a synergic effect in combined medication, so that the inhibition to the tumors can be further enhanced.
Owner:CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI

Early stage detection molecular marker of Angiostrongylus cantonensis disease and primer

The invention belongs to the field of biology, and relates to early stage detection molecular marker of early stage Angiostrongylus cantonensis disease, and primer and correlated kit thereof. The necessary composition of the diagnostic reagent contains: aca-miR-146a-5p sequence and three related primers (stem loop primer, upstream and downstream primer) designed according to the sequence design. The invention firstly provides an application of aca-miR-146a-5p in preparation for diagnosis of Angiostrongylus cantonensis disease. The diagnostic reagent can accurately and simply detect infection of Angiostrongylus cantonensis at early stage, and can distinguish between meningitis or encephalitis caused by Angiostrongylus cantonensis and other meningitis or encephalitis with good social and economic benefits.
Owner:SUN YAT SEN UNIV

Human body gait monitoring algorithm based on dynamic time planning

The invention discloses a human body gait monitoring algorithm based on dynamic time planning, and belongs to the field of human body gait recognition methods. An existing gait recognition method is low in recognition precision. The human body gait monitoring algorithm based on dynamic time planning comprises the following steps: acquiring a human body gait video by using a visual sensor, and establishing a human body gait model; acquiring skeleton movement information by adopting a sensor skeleton technology; training a gait monitoring recognition algorithm; performing motion recognition; and performing human gait skeleton diagnosis and evaluation. According to the gait diagnosis and evaluation carried out by the method, the recognition rate can reach 98% at most.
Owner:黑龙江省科学院智能制造研究所

Remote-monitoring peristaltic pump transfusion system

InactiveCN103386154AQuality improvementAppropriate treatment planPressure infusionPeristaltic pumpNatural disaster
The invention provides a remote-monitoring peristaltic pump transfusion system which mainly consists of a computer host, a wireless routing and switching host, peristaltic pump transfusion instruments, high-definition cameras and the like, wherein each peristaltic pump transfusion instrument consists of main parts such as a peristaltic pump, a lithium battery, a micro computer main circuit board, a transfusion bag, a transfusion bag fixing rack, a weight sensor, a bubble monitoring device, a dripping speed monitoring device, a charging socket, a liquid crystal display screen, a micro speaker, an alarm indicating lamp, a functional key, an LED (Light-Emitting Diode) illuminating lamp, a transfusion (blood transfusion) pipe and a plastic shell. The remote-monitoring peristaltic pump transfusion system has the following beneficial effects: one computer host is connected with the multiple peristaltic pump transfusion instruments by virtue of the wireless routing and switching host and is used for monitoring and controlling, so that manpower source is greatly saved, the transfusion condition of patients can be monitored at any timely, and the use safety is improved; and the remote-monitoring peristaltic pump transfusion system is simple and convenient in fixation, convenient to carry, and particularly suitable for blood transfusion and transfusion on the way of slavaging and transferring patients during wartime, natural disaster and pre-hospital rescue processes.
Owner:陈大军 +2

Realization of kernel function predicted signal peptide and broken point based on sequence ratio

InactiveCN1818916AAvoid the disadvantage of low prediction rateSolve problems that do not satisfy non-negative definite conditionsSpecial data processing applicationsSequence signalCharacteristic space
The realization method is part of the biology project technology field, based on sequence alignment nuclear function to forecast signal peptide and its breakpoint position. The invention adopt full sequence alignment to settle the problem that the amino acid sequence lengths are disagreement, and count the relativity between two amino acid sequences to reflect the similarity of both. The new coordinate is made by space transform, after the similarity matrix transform non-negative fix matrix; it settle the problem how make a matrix of dissatisfied non-negative fix condition into a nuclear matrix. For a new amino acid sequence, at its new characteristic space, the said method can forecast whether it is a signal peptide and estimate its breakpoint position. The said invention increase the correctness of forecast signal peptide and forecast breakpoint, so it has a great effect to understand the cause of some illness and is helpful to explore effective cure precept.
Owner:SHANGHAI JIAO TONG UNIV

Traditional Chinese medicine preparation treating heart-kidney imbalance type insomnia

The invention provides a traditional Chinese medicine preparation treating heart-kidney imbalance type insomnia. The preparation is prepared from phellodendron chinense schneid, hen egg yolk, donkey-hide glue, prepared rehmannia roots, white peony roots, glossy privet fruits, lilies, tuber fleeceflower stems, polygala tenuifolia, spina date seed, cortex albiziae, radix scutellariae, radix gentianae, gardenia jasminoides, lophatherum gracile, platycladi seeds, light wheat, radix asparagi, coix seeds, Chinese yam, fructus lycii, acorus tatarinowii, honey-fried licorice roots and cinnamon. The preparation is remarkable in treatment effect, the effects are better than those of old methods, and an economical, effective and quick treatment scheme is provided for insomnia patients.
Owner:QINGDAO JINZHI HIGH NEW TECH

Method for assessing mental illness incidence risks for mental health help seekers in China

The invention relates to a method for assessing mental illness incidence risks for mental health help seekers in China. The method for estimating the mental illness incidence risks comprises the following steps: S1, conducting a brief international neuropsychiatric interview and establishing a baseline; S2, conducting a psychiatric high-risk syndrome structured interview; S3, conducting MCCB neurocognitive assessment; S4, selecting variables for calculation; S5, outputting a prediction result, wherein the variables in S4 include ages, BACS symbolic coding scores, HVLT-R scores, P1 and P2 scores, GAF score changes of one year, and mental illness histories of first degree relatives. The method has the advantages of being high in accuracy, helping doctors to effectively select therapeutic schemes and improving the therapeutic effect of clinical prognosis of patients.
Owner:SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)

Traditional Chinese medicine acupoint patch for treating insomnia of women in perimenopausal period

The invention provides a traditional Chinese medicine acupoint patch for treating insomnia of women in the perimenopausal period. Raw medicine materials of the traditional Chinese medicine acupoint patch include rhizoma coptidis from Sichuan of China, yolk, colla corii asini, radix rehmanniae preparata, radix paeoniae alba, fructus ligustri lucidi, bulbus lilii, ratan of polygonum multiflorum, radix polygalae, semen ziziphi spinosae, cortex albiziae, radix scutellariae, plumula nelumbinis, fructus gardeniae, herbal lophatheri, seman platycladi, light wheat, cochinchinese asparagus roots, semen coicis, common yam rhizomes, fructus lycii, rhizoma acori tatarinowii, radix glycyrrhizae preparata and cortex cinnamomi. The traditional Chinese medicine acupoint patch is remarkable in treatment effect, the effect is superior to that of an old method or an old formula, and an economical, effective and rapid treatment scheme is provided for insomniacs.
Owner:孙中莎

Bacterial drug resistance fluorescence detection method and diagnostic kit thereof

The invention provides a fluorescence detection method for detecting bacterial drug resistance in an individual and a diagnostic kit / diagnostic reagent thereof. According to the fluorescence detection method, absorbance difference under the condition of different wavelengths is detected by using a fluorogenic substrate, which only can be degraded by broad spectrum beta lactamase, through double fluorescence signals and further the bacterial drug resistance of the individual or the biological sample of the individual can be detected. The detection method and the obtained detection kit based on the method can detect the 3rd and 4th generations of drug-resistance bacteria of cephalosporin, which cannot be detected by products available in the markets and can reach a detection value of 10<5>-10<8> drug-resistance bacteria, so that a market blank is filled in, more effective monitoring method and use guide are provided for the use of antibiotics in clinic, and extremely great practical values are achieved.
Owner:SHANGHAI BAIKE BIO TECH CO LTD

A prescription for treating ascites due to cirrhosis and a preparing method thereof

InactiveCN107041939AImprove clinical symptomsImprove clinical symptoms, improve liver functionDigestive systemMammal material medical ingredientsSide effectPortal vein
The invention relates to a prescription for treating ascites due to cirrhosis and a preparing method thereof. The prescription includes musk, radix euphorbiae kansui, earthworm and villous amomum fruit. The prescription includes 1-3 parts by weight of the musk, 0.5-2 parts by weight of the radix euphorbiae kansui, 5-15 parts by weight of the earthworm and 8-13 parts by weight of the villous amomum fruit. The method includes 1) a step of weighing medicine materials, 2) a step of cleaning and drying the medicine materials, 3) crushing the medicine materials, and 4) blending the crushed medicine materials into medicine paste. By adopting liver function improving and portal vein haemodynamic interference as breakthrough points, an umbilicus external application manner is adopted, and the holistic view and advantages of treatment based on syndrome differentiation of the traditional Chinese medicine are fully utilized to treat the ascites due to cirrhosis and portal hypertension. The prescription has characteristics of a simple and effective treatment scheme, a low cost, few adverse effects and capability of being easily accepted by patients, and being widely popularized and applied in primary hospitals. The prescription improves clinical symptoms of patients with ascites due to cirrhosis, improves liver functions, reduces portal vein pressure, and is free of obvious toxic or side effects.
Owner:刘春光

Combined drug composition for breast cancer immunotherapy and application of combined drug composition

ActiveCN110464845AEffective treatment optionsStem transformation inhibitionAntibody ingredientsAntineoplastic agentsMalignant progressionWilms' tumor
The invention discloses a combined drug composition for breast cancer immunotherapy and an application of the combined drug composition. The combined drug composition comprises an SR1664 inhibitor ineffective quantity and an immunologic test point blocking antibody in effective quantity. The invention further provides a tumor immunotherapy drug combination method. The inventor finds that SR1664 can be used for resisting tumor malignant progression of PPAR gamma phosphorylation mediated with CDK5. The tumor relevant macrophage phenotype and function in tumor microenvironment can be adjusted and controlled, so that the T cellular infiltration is improved, and the immunosuppression tumor microenvironment can be further reversed. Through synergism of the SR1664 and the immunologic test pointblocking antibody, tumor restraining can be further reinforced.
Owner:NANJING UNIV

Circular RNA molecule and application thereof in targeted degradation of target protein

The invention belongs to the field of biological medicine, and particularly relates to a circular RNA molecule, a cyclized precursor RNA molecule, a recombinant nucleic acid molecule, a recombinant expression vector, a recombinant host cell, a composition, application of the composition in targeted degradation of target protein and a method for preventing or treating diseases. The circular RNA molecule has good membrane permeability, is easy to be delivered into cells, and has efficient in-vivo protein targeted degradation activity. According to the circular RNA molecule disclosed by the invention, tumor growth inhibition is successfully realized, the in-vivo protein degradation activity of the bio-PROTACs is proved for the first time, and a positive and effective treatment scheme is provided for treatment of diseases such as tumors.
Owner:SUZHOU CUREMED BIOMEDICAL TECH CO LTD

Novel use of PK11195

The invention belongs to the technical field of medicine, relates to novel use of PK11195, and particularly relates to the use of PK11195 or a pharmaceutically acceptable salt thereof in the preparation of a medicine / cosmetic for treating and / or preventing hyperpigmented diseases, especially the use in preparation of a medicine / cosmetic for treating and / or preventing various hereditary, ultraviolet and inflammatory factors-induced hyperpigmentation such as freckles, pregnancy spots, melasma, coffee spots and moles.
Owner:CHANGZHOU UNIV

Medicine bottle capable of collecting medicine taking data of patient

The invention discloses a medicine bottle capable of collecting medicine taking data of a patient. The medicine bottle comprises an opaque bottle cover, an opaque bottle body, a display unit, a weighing unit, an opening sensing unit, a control unit, a posture sensing unit and a wireless communication unit. The display unit is installed on the outer side wall of the bottle body. The opening sensing unit is installed at the upper portion of the inner side wall of the bottle body. The weighing unit is installed on the upper layer of the inner surface of the bottom of the bottle body. The control unit, the posture sensing unit and the wireless communication unit are all installed in the bottom of the bottle body. The display unit, the opening sensing unit, the weighing unit, the posture sensing unit and the wireless communication unit are all electrically connected with the control unit. The medicine bottle can continuously collect medicine taking time, medicine taking amounts and other data of the patient and can also transmit the data to an external wireless mobile communication device and transmit the data to a cloud side or other data centers through the external wireless mobile communication device.
Owner:张彦龙

Application of Artemisia carvifolia in preparation of gastrointestinal disease treatment drugs

The invention discloses an application of Artemisia carvifolia in the preparation of gastrointestinal disease treatment drugs, and belongs to the technical field of drugs. Artemisia carvifolia has the advantages of improvement of the symptoms of gastrointestinal diseases, lasting curative effect and no obvious untoward effects in the treatment of Helicobacter pylori infected gastrointestinal diseases, and is suitable for treating gastritis, gastric and duodenal ulcer or nausea, vomiting, abdominal pain, diarrhea and other diseases.
Owner:唐桂益 +1

Chest X-ray display device with adjusting mechanism

The invention discloses a chest X-ray display device with an adjusting mechanism. The chest X-ray display device comprises a bed board, a perspective body, a main body and a groove, wherein a liftingrod is arranged on the right side of the bed board, a flexible rod is arranged at the top of the lifting rod, the perspective body is fixed to the top end of the flexible rod, a pillow is arranged atthe top of the bed board, a clamping groove is formed in the inner side of the pillow, the left end of the bed board is connected with a wood plate, a transverse plate is arranged on the outer wall ofthe wood plate, a fixing plate is arranged at the bottom of the transverse plate, a supporting body is installed at the top end of the transverse plate, the main body is fixed to the top of the supporting body, a display screen is arranged on the inner side of the main body, and supporting columns are arranged at the bottom of the bed board. Through arrangement of the bed board, the lifting rod,the flexible rod and the perspective body, the central axis of the lifting rod coincides with the central axis of the bed board, and through the lifting effect of the lifting rod, the height of the perspective body can be adjusted, so that the device works more smoothly.
Owner:青岛卓森纳生物工程有限公司

Broad-spectrum beta-lactamase fluorescent substrate, and preparation method and application thereof

The invention provides a broad-spectrum beta-lactamase fluorescent substrate applied to a fluorescence detection method capable of detecting the drug resistance of bacteria in a single body. The structure of the broad-spectrum beta-lactamase fluorescent substrate is shown in the specification. An experiment result indicates that the fluorescent substrate C-2 provided by the invention can accurately and qualitatively detect cephalosporin resistant bacteria in different samples, can be applied to clinical or other detection fields to prepare a corresponding diagnostic reagent or diagnostic kit, and has broad application space and a high practical value.
Owner:SHANGHAI BAIKE BIO TECH CO LTD

Application of indometacin in preparation of medicines for treating cough

The invention relates to application of indometacin in preparation of medicines for treating cough. The indometacin is applied to preparation of medicines for treating cough. The indometacin has obvious effects on treating chronic cough and especially refractory cough in chronic cough and provides an effective treatment scheme for difficult and complicated diseases with unknown pathogenesis and complicated pathogenesis.
Owner:THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +1

Combined Drug Combinations for Tumor Immunotherapy

The invention provides a drug combination for tumor immunotherapy, which includes an effective amount of an acyl-CoA:cholesterol acyl transferase ACAT1 inhibitor and an effective amount of an immune checkpoint blocking antibody. The present invention further provides a combination drug method for tumor immunotherapy. The present invention finds that inhibiting acyl-CoA:cholesterol acyltransferase ACAT1 can enhance the tumor-killing activity of CD8 T cells, and in combination with immune checkpoint blocking antibodies, the two can have a synergistic effect, and can further enhance the anti-tumor activity. inhibition.
Owner:CENT FOR EXCELLENCE IN MOLECULAR CELL SCI CHINESE ACAD OF SCI

Method and device for measuring morphological parameters of intracranial aneurysm images

The invention discloses a method and device for measuring morphological parameters of an intracranial aneurysm image. The method includes constructing a three-dimensional model including a parent artery and an aneurysm on the parent artery according to intracranial image data. The three-dimensional model includes The virtual parent artery matched with the parent artery and the virtual aneurysm matched with the aneurysm; the neck plane of the virtual aneurysm is determined based on the three-dimensional model, and the target morphological parameters are determined based on the three-dimensional model and the neck plane. The morphological parameters include at least morphological parameters of the virtual aneurysm. It can be seen that the implementation of the present invention automatically measures the morphological parameters of intracranial aneurysms through the three-dimensional model of intracranial image data and the neck plane of the virtual aneurysm included in the three-dimensional model, which can not only improve the measurement of the morphological parameters of intracranial aneurysms The accuracy of the results can improve the measurement speed of the morphological parameters of intracranial aneurysms, thereby providing scientific reference for medical staff when making treatment decisions.
Owner:唯智医疗科技佛山有限公司

Cloud-based cross-medical conjoined multidisciplinary joint consultation system

The invention provides a cloud-based cross-medical conjoined MDT consultation system, belongs to the field of medical treatment, is used for solving the problem that cross-medical conjoined consultation cannot be realized among traditional Chinese medicine conjoined bodies in the prior art, and is beneficial to advantage complementation and reasonable resource utilization of current medical technologies. The consultation system comprises an incidence relation setting module, a cross-medical conjoined consultation application initiating module, a medical record data pushing module, a first auditing module, a consultation data sending module, a consultation module, a consultation diagnosis and treatment scheme sending module, a second auditing module and a final diagnosis and treatment scheme sending module. Based on the consultation system, the problem that cross-medical conjoined consultation cannot be carried out between two medical conjoined bodies is solved.
Owner:B SOFT CO LTD

A chimeric antigen receptor targeting bcma and its application

The invention relates to a chimeric antigen receptor targeting BCMA, which comprises an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, wherein the extracellular domain is an anti-BCMA single domain antibody; wherein the amino acid sequence of the anti-BCMA single domain antibody is selected from: (a) an amino acid sequence as shown in SEQ ID NO. 1; or (b) a variant which is formed by substitution, addition or deletion of one or more amino acids in the amino acid sequence shown in SEQ ID NO. 1 and which is capable of specifically binding to the chimeric antigen receptor and has a function of binding to BCMA and inducing T cell signaling conduction. The chimeric antigen receptor has smaller clinical side effects and highersafety, can effectively reduce solid tumor focus and effectively improve the treatment effect of tumors.
Owner:GUANGZHOU BIO GENE TECH CO LTD

Composition containing sulfonylureas sugar-reducing drug and statins lipid-lowering drug

The invention relates to a compound of sulfaurea drug and statins lipid lowering drug, belonging to the pharmaceutical field. The compound contains sulfaurea drug of therapy dose or salts of the sulfaurea, statins lipid lowering drug with low therapy dose or the pharmaceutical salt and pharmaceutical carrier or excipient. The invention also relates to the purpose of the compound in preparation of drug for preventing and treating a living body ill with diabetes and lipid metabolism disorder, providing an effective therapeutic schedule for the diabetes and lipid metabolism disorder.
Owner:BEIJING HUAANFO BIOMEDICAL RES CENT
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