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New use of J147

A technology of 1.J147, use, applied in the new use field of J147, can solve the problems of unseen pigment synthesis and so on

Active Publication Date: 2021-10-08
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at present, there are no reports of its inhibitory effect on pigment synthesis at home and abroad.

Method used

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  • New use of J147
  • New use of J147
  • New use of J147

Examples

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Embodiment Construction

[0028] In order to further clarify the present invention, a series of examples are given below, these examples are completely illustrative, they are only used to specifically describe the present invention, and should not be construed as limiting the present invention.

[0029] Below are part pharmacodynamic tests and results of the present invention:

[0030] Part 1: Effect of J147 on Melanin Synthesis in Normal Human Epidermal Melanocyte Line PIG1

[0031] 1. The effect of J147 on the proliferation of normal human epidermal melanocyte cell line PIG1

[0032] The normal human epidermal melanin cell line PIG1 in good exponential growth phase was taken, digested, counted, and then the cells were seeded in 96-well culture plates (seeding density: 5×10 4 cells / ml, inoculation volume: 180 μl / well), placed at 37°C, 5% CO 2 Cultivate in an incubator for 24 hours; then add different concentrations of J147, put it into the incubator to continue culturing; after 48 hours, add 20 μl M...

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Abstract

The invention belongs to the technical field of medicines, relates to new use of J147 and particularly relates to use of the J147 or pharmaceutically acceptable salts thereof in preparation of medicines / cosmetics for treating and / or preventing hyperpigmentation diseases, particularly various pigmented skin diseases such as chloasma, hyperpigmentation after inflammation and senile freckles.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a new application of J147. Background technique [0002] Under normal physiological conditions, melanin protects human skin from damage such as ultraviolet rays, toxic chemicals, and other environmental factors. However, the overproduction and abnormal accumulation of melanin can lead to hyperpigmented diseases such as melasma, post-inflammatory hyperpigmentation, and senile lentigo, resulting in severe psychosocial burden. Therefore, it is very necessary to find effective melanin synthesis inhibitors. At present, it has been found that various proteins in the body are involved in the synthesis of melanin in the skin. Among them, tyrosinase (Tyrosinase) is a key enzyme involved in melanin synthesis, and inhibiting the catalytic activity of tyrosinase is the most commonly used method to inhibit melanin production. Some known tyrosinase inhibitors, including arbutin ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61P17/00A61K8/69A61Q19/02
CPCA61K31/167A61P17/00A61K8/69A61Q19/02
Inventor 吕金鹏杨莹张逸翔张锡梅高榕荫宋国强
Owner CHANGZHOU UNIV
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