Biodegradable material for treating orthopedic diseases and application thereof

A biodegradable material, orthopedic disease technology, applied in medical science, drug delivery, prosthesis, etc., can solve problems such as high cost, thrombosis, lack of trauma in osteoarthritis, achieve good biocompatibility, improve joints Function, effect of protecting articular cartilage

Active Publication Date: 2019-03-22
广州噢斯荣医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, surgical treatment such as joint replacement is not only expensive, but also wears and loosens after long-term activities, requiring revision, and there may be catastrophic complications such as postoperative thrombosis, infection after replacement, and amputation.
[0007] In view of the current situation that oral drugs can only relieve symptoms, the role of intra-articular injection drugs in alleviating the disease process is controversial, surgical treatment is expensive and there is a risk of infection, there is still a lack of a fast, effective and minimally invasive treatment for osteoarthritis

Method used

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  • Biodegradable material for treating orthopedic diseases and application thereof
  • Biodegradable material for treating orthopedic diseases and application thereof
  • Biodegradable material for treating orthopedic diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of Injection Molded Biodegradable Materials for Treatment of Osteoarthritis

[0034] Accurately weigh glycolide-lactide copolymer (PLGA) and N-methylpyrrolidone (NMP), the weight ratio of the two is 10:90; transfer N-methylpyrrolidone (NMP) to a stainless steel liquid mixing tank , stir with a stirring paddle at low speed (200-400rpm), slowly add PLGA powder to disperse and fully dissolve to obtain a relatively stable solution system; then use a 0.22 μm sterile filter to filter and sterilize the solution system. Filtration is completed and filled to obtain an injection-molded biodegradable material for treating osteoarthritis. Protect from light and store at room temperature.

[0035] The product requires technical testing, including observation, identification, and determination of molecular weight. At the same time, heavy metals, solvent residues, moisture, sterility, bacterial endotoxins, biological properties, physical and mechanical propertie...

Embodiment 2

[0037] Example 2 Preparation of Injection Molded Biodegradable Materials for Treatment of Osteoarthritis

[0038] Except that the weight ratio of glycolide-lactide copolymer (PLGA) and N-methylpyrrolidone (NMP) is 5:95; other preparation processes are the same as in Example 1.

Embodiment 3

[0039] Example 3 Preparation of Injection Molded Biodegradable Materials for Treatment of Osteoarthritis

[0040] Except that the weight ratio of glycolide-lactide copolymer (PLGA) and N-methylpyrrolidone (NMP) is 50:50; other preparation processes are the same as in Example 1.

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Abstract

The invention discloses a biodegradable material for treating orthopedic diseases and an application thereof. The biodegradable material for treating the orthopedic diseases is a material which formsa solid or semi-solid molded shape after being injected into a subchondral bone with osteoarthritis. The biodegradable material for treating the orthopedic diseases, disclosed by the invention, has the advantages that the biodegradable material is injected into the subchondral bone of a bone joint to create a beneficial environment for damaged bone tissue repairing and regeneration so as to achieve effects of relieving arthralgia, protecting cartilago articularis, improving a motion function and the like. The biodegradable material for treating the orthopedic diseases, disclosed by the invention, has the advantages that the biodegradable material is safe and nontoxic, good biocompatibility is realized, osteoarthritis is rapidly and effectively treated, and wounds are extremely small. The biodegradable material for treating the orthopedic diseases, disclosed by the invention, has the advantages that symptoms, such as pains, of patients are fundamentally relieved by using the subchondralbone as a target point part, the joint function is improved, and the state of an illness is stopped against being developed to a more serious direction.

Description

technical field [0001] The invention belongs to the field of medical equipment, and in particular relates to a biodegradable material for treating orthopedic diseases (such as osteoarthritis and bone marrow edema) and an application thereof. Background technique [0002] Osteoarthritis (OA) is a chronic damage to articular cartilage and surrounding tissues, characterized by pain, stiffness, and loss of joint function, which seriously affects the quality of life of patients. Osteoarthritis is the most common joint disease. The latest statistics show that there are 355 million people with arthritis worldwide. As of 2015, there were more than 120 million arthritis patients in mainland China, with an incidence rate of about 13%, and an incidence rate of more than 50% among people aged 60-75. [0003] The pathological features of OA are degeneration and destruction of articular cartilage, subchondral bone sclerosis, bone marrow edema (bone marrow lesion, BML) in the subchondral ...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61L31/14A61L27/58
CPCA61L27/58A61L31/148A61L2400/06
Inventor左联张涛路红艳吴雯汤小强
Owner广州噢斯荣医药技术有限公司