Traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and application of traditional Chinese medicine composition

A technology of peripheral neuropathy and composition, applied in the field of medicine, can solve problems such as hindering nerve function, nerve cell damage, lack of therapeutic drugs, etc., and achieve the effect of improving inflammatory response and relieving neuralgia
CN109512948APending Publication Date: 2019-03-26南京爱立克生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南京爱立克生物科技有限公司
Publication Date
2019-03-26

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy. The traditional Chinese medicine composition is prepared byextracting the following bulk drugs in parts by weight: 20-50 parts of radix paeoniae rubra, 15-35 parts of salvia miltiorrhiza, 25-45 parts of radix achyranthis bidentatae and 20-45 parts of stem ofnoble dendrobium. It is found that the traditional Chinese medicine composition has a preventive and therapeutic effect on chemotherapy-induced peripheral neuropathy and dorsal root ganglion injury byestablishing an in-vivo mouse model, blood stasis diseases characterized by pain and numbness in lower limbs can be treated, no toxic side effects is caused, no drug dependence is caused, the formulais simple, and the cost is low.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and its application. Background technique

[0002] Chemotherapy-induced peripheral neuropathy (Chemotherapy-induced peripheral neuropathy, CIPN) is a neurotoxic lesion caused by direct damage to the peripheral nervous system by chemotherapy drugs. 2010, 25(2):116-131). Its clinical manifestations mainly include sensory and motor abnormalities, such as limb weakness, numbness, tingling, burning sensation, glove-like or stocking-like abnormal sensation, cold hyperalgesia, gait and balance disturbance, loss of limb function, and autonomic nervous dysfunction etc. (Chinese Journal of Pain Medicine, 2010, 16 (5): 302-304), affect the curative effect and seriously reduce the quality of life of patients.

[0003] Common clinical chemotherapy drugs that cause periphera...

Claims

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