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Traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and application of traditional Chinese medicine composition

A technology of peripheral neuropathy and composition, applied in the field of medicine, can solve problems such as hindering nerve function, nerve cell damage, lack of therapeutic drugs, etc., and achieve the effect of improving inflammatory response and relieving neuralgia

Pending Publication Date: 2019-03-26
南京爱立克生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most studies have shown that peripheral neuritis caused by oxaliplatin is related to the accumulation of oxalate in the dorsal root ganglia of the spinal cord. Since it is difficult to metabolize it or excrete it in a short time by other means, a large amount of oxalate accumulated Salt hinders normal nerve function, causing varying degrees of damage to nerve cells
There is currently a lack of effective treatments

Method used

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  • Traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and application of traditional Chinese medicine composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of tablet

[0028] 1. Prepare materials

[0029] 1.1. Radix Paeoniae Rubra: Take the original medicinal materials, remove impurities, separate the large and small strips, wash, soak until 60% to 70% transparent, cut into thin slices, dry, and sieve to remove debris;

[0030] 1.2 Danshen: clean impurities, remove rhizomes, wash, remove, moisten, slice and dry;

[0031] 1.3 Achyranthes bidentata: remove impurities, wash, moisten, cut into sections, and dry in the sun;

[0032] 1.4 Dendrobium: Take dried Dendrobium, soak it in water until it is 80% transparent, simmer and moisten, remove residual roots and black branches, cut into sections, knock off the film, and dry in the sun.

[0033] 2. Preparation

[0034] Weigh 35 parts of red peony root, 25 parts of salvia miltiorrhiza, 35 parts of Achyranthes bidentata, and 25 parts of dendrobium, add 8 times of water to soak for 1 hour, decoct for 1 hour, filter and keep the filtrate, add 6 times ...

Embodiment 2

[0035] Embodiment 2: Chinese medicine composition of the present invention (Siwei Jianbu Decoction (JB)) prevents and treats the peripheral neuropathy caused by chemotherapy in animal models

[0036] 1. Experimental materials and methods

[0037] Instruments: Tianneng 5200Multi multifunctional imaging system, Bio-Rad electrophoresis instrument, Olympus IX71 fluorescence microscope, Dynamic Plantar Aesthesiometer (DPA, Ugo Basile, Italy), Plantar test 37370 (Ugo Basile, Italy), ultrasonic cell pulverizer (Biosafer900-92), nanodrop one (Thermoscientific), real-time fluorescent quantitative PCR instrument (ABI 7500, USA), gradient PCR instrument (ABI, USA), desktop high-speed refrigerated centrifuge (eppendrof, Germany), HB120-S metal constant temperature heating device (SCILOGEX, USA).

[0038] Reagents: paclitaxel, oxaliplatin, and polyoxyethylene castor oil were purchased from Shanghai Yuanye Company; red peony root, salvia miltiorrhiza, achyranthes bidentata, and dendrobium we...

Embodiment 3

[0048] Embodiment 3: pain behavior test

[0049] On the day before dosing, conduct the first behavioral test on experimental animals.

[0050] 1. Body weights were recorded weekly (before the start of each ethology). Body weight records are shown in Table 1.

[0051] 2. Tactile detection of mechanical pain: In this experiment, Dynamic Plantar Aesthesiometer was used to measure the mechanical paw withdrawal reflex threshold of mice, which were carried out on the 0th, 7th, 14th, 21st, 28th, 35th, and 42nd day respectively. Place the mouse in a plexiglass box on a metal screen to adapt for 30 minutes, calibrate the tactile meter, and use a 0.5mm filament to increase the intensity of stimulation to the middle of the mouse's sole (setting frequency is 1g / s, maximum force is 10g ), slowly increase the stimulus pressure, and when the paw withdrawal response occurs, the system records the latency time and the pressure when the animal has the paw withdrawal response. Each mouse was ...

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Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy. The traditional Chinese medicine composition is prepared byextracting the following bulk drugs in parts by weight: 20-50 parts of radix paeoniae rubra, 15-35 parts of salvia miltiorrhiza, 25-45 parts of radix achyranthis bidentatae and 20-45 parts of stem ofnoble dendrobium. It is found that the traditional Chinese medicine composition has a preventive and therapeutic effect on chemotherapy-induced peripheral neuropathy and dorsal root ganglion injury byestablishing an in-vivo mouse model, blood stasis diseases characterized by pain and numbness in lower limbs can be treated, no toxic side effects is caused, no drug dependence is caused, the formulais simple, and the cost is low.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition for preventing and treating peripheral neuropathy caused by chemotherapy and its application. Background technique [0002] Chemotherapy-induced peripheral neuropathy (Chemotherapy-induced peripheral neuropathy, CIPN) is a neurotoxic lesion caused by direct damage to the peripheral nervous system by chemotherapy drugs. 2010, 25(2):116-131). Its clinical manifestations mainly include sensory and motor abnormalities, such as limb weakness, numbness, tingling, burning sensation, glove-like or stocking-like abnormal sensation, cold hyperalgesia, gait and balance disturbance, loss of limb function, and autonomic nervous dysfunction etc. (Chinese Journal of Pain Medicine, 2010, 16 (5): 302-304), affect the curative effect and seriously reduce the quality of life of patients. [0003] Common clinical chemotherapy drugs that cause periphera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61P25/00A61P25/02
CPCA61K36/8984A61P25/00A61P25/02A61K36/21A61K36/537A61K36/65A61K36/71A61K2300/00
Inventor 朱静张秋艳杨超
Owner 南京爱立克生物科技有限公司
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