Modeling equipment, modeling method and application of a mouse intervertebral disc degeneration model

An intervertebral disc and modeling technology, applied in the field of intervertebral disc degeneration research, can solve the problems of unreliability, large specific gravity, long cycle, etc., and achieve the effect of increasing axial stress and accelerating the degeneration process.
CN109528341BActive Publication Date: 2021-06-04南方医科大学第三附属医院(广东省骨科研究院)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
南方医科大学第三附属医院(广东省骨科研究院)
Publication Date
2021-06-04

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Abstract

The invention discloses a model-making device, a model-making method and an application of a mouse intervertebral disc degeneration model. The molding equipment includes: one or more molding cylinders and a water tank for placing the molding cylinders, the position of the side wall of the molding cylinders close to the bottom wall or the bottom wall of the molding cylinders is provided with a plurality of water-permeable holes, and the water-permeable The hole communicates with the cavity inside the cylinder for placing the mouse. The modeling equipment can guide the water-avoiding habit of mice, make them maintain bipedal standing posture for a long time, increase the axial stress of mice, accelerate the process of lumbar disc degeneration, form a model of intervertebral disc degeneration, and provide a basis for the mechanobiology of intervertebral disc degeneration. Mechanistic studies of signal transduction provide effective mechanistic animal models.
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Description

technical field

[0001] The invention relates to the field of intervertebral disc degeneration research, in particular to a modeling device, a modeling method and an application for a mouse intervertebral disc degeneration model. Background technique

[0002] Intervertebral disc degeneration is an important factor leading to low back pain, and animal models are an important basis for the study of intervertebral disc degeneration. For a long time, mice have been widely used in the study of intervertebral disc degeneration as an important experimental animal. Its advantages are as follows: 1. Low price and easy operation; 2. Short time period and high benefit; 3. Tissue probes and markers Fourth, the genome is easy to modify, and a variety of genetically modified mice can be created for related research

[0003] At present, the methods of intervertebral disc modeling in mice mainly fall into the following categories: 1. Mechanically induced models, including pressure models an...

Claims

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