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Preparation method of Chinese wolfberry root bark formula granules

A technology of formula granules and Digupi, which can be applied in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as formula granules of Digupi that have not yet been seen, improve the physical dissolution and transfer rate, and reduce degradation and damage. , the effect of improving product quality

Inactive Publication Date: 2019-04-05
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparation of Digupi formula granules by continuous dynamic countercurrent water extraction process

Method used

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  • Preparation method of Chinese wolfberry root bark formula granules

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation method of Digupi formula granules, comprising the steps of:

[0043] a. Select Digupi medicinal material, vibrate and sieve to remove impurities to obtain Digupi decoction pieces, and then crush it into 1.0cm coarse particles with a crusher;

[0044] b. Wet the coarse particles with 2 times the amount of water, and continuously input the extraction tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) from the feed port at the front end, and pass through a set of spiral structures in the extraction tube. Continuously push the material forward to the slag outlet of the extraction tube to discharge the slag, and continuously add 16 times of 90°C hot water at the end of each level of extraction tube for continuous countercurrent extraction for 2 hours, and the hot water and the material flow in reverse to each level of extraction The front end of the pipe discharges the liquid, collects the extraction liquid, an...

Embodiment 2

[0049] In step c, the combined extracts are directly sterilized in an ultra-high temperature instantaneous sterilizer (UHT) at 105°C for 20 seconds without cooling down, and then concentrated under reduced pressure at 60°C to form a clear paste with a relative density of 1.06;

[0050] All the other are with embodiment 1.

Embodiment 3

[0052] In step b, the coarse particles are not wetted, and are continuously input into the leaching tube of the spiral continuous countercurrent extraction machine (two-stage 10-section tube structure) through the feeding port at the front end, and the material is discharged through a set of helical structures in the leaching tube Continuously push forward to the slag outlet of the leaching tube to discharge the slag, and continuously add 16 times of 90°C hot water at the end of the leaching tube at each level for continuous countercurrent extraction for 2 hours. The liquid is discharged from the front end, the extract is collected, and the Digupi medicinal residue is discharged; the input speed of the Digupi decoction pieces is 100kg / h, and the flow rate of adding hot water in reverse is 1600L / h;

[0053] All the other are with embodiment 1.

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Abstract

The invention discloses a preparation method of Chinese wolfberry root bark formula granules. The preparation method includes the steps that a, Chinese wolfberry root bark decoction pieces are crushedor chopped into coarse particles; b, the coarse particles are continuously fed into a continuous countercurrent extraction machine, hot water is continuously added in the reverse direction at the tail end of each extraction pipe, continuous dynamic countercurrent extraction is conducted, an extracting solution is collected, and decoction dregs are discharged; c, the extracting solution is filtered, superhigh temperature instantaneous sterilization is conducted, and the filtrate is decompressed and condensed into pure paste; d, ingredients are added to the pure paste to dissolve, and dry extract powder is obtained by spray drying; e, the dry extract powder is added to the preparation ingredients, and the Chinese wolfberry root bark formula granules are obtained by dry granulation. According to the preparation method of the Chinese wolfberry root bark formula granules, continuous countercurrent extraction, high temperature instantaneous sterilization, vacuum concentration, spray drying,dry granulation production processes are adopted, process parameters are studied, thus the content of effective components in the formula granules can reach a high level continuously and stably, it is ensured that the transfer rate of active components is consistent with that of the standard decoction, and the product quality of the Chinese wolfberry root bark formula granules is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Digupi formula granules. Background technique [0002] Digupi is the dry root bark of Lycium chinense Mill. or Lycium barbarum L., a plant of the family Solanaceae. The roots are excavated in early spring or after autumn, washed, peeled off the root bark, and dried in the sun. [0003] Traditional Chinese medicine formula granules are made by extracting, concentrating, drying, and granulating single-flavored Chinese medicine decoction pieces. The quality level of traditional Chinese medicine formula granules is evaluated based on the consistency of the three major indicators of paste yield, fingerprint or characteristic map, and transfer rate (or content) of main active ingredients with standard decoctions (prepared by traditional Chinese medicine decoctions) of. [0004] As an industrialized product, tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/16A61L2/04
CPCA61K36/815A61K9/1652A61K2236/15A61K2236/331A61K2236/51A61L2/0023A61L2202/21
Inventor 王超严玉晶孙冬梅干丽李燕珍李美洲肖艳慧蔡盛康魏梅
Owner GUANGDONG YIFANG PHARMA