Modeling method for adverse reactions of digestive tract after chemotherapy, model and application

A technology for model establishment and adverse reactions, which can be used in medical preparations containing active ingredients, pharmaceutical formulations, compound screening/testing, etc.

Inactive Publication Date: 2019-04-16
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toxic and side effects not only affect the quality of life of patients, but also limit the therapeutic effect of chemotherapy drugs

Method used

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  • Modeling method for adverse reactions of digestive tract after chemotherapy, model and application
  • Modeling method for adverse reactions of digestive tract after chemotherapy, model and application

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Experimental program
Comparison scheme
Effect test

Embodiment

[0043] Experimental Drugs:

[0044] Oxaliplatin (50mg / bottle) (Jiangsu Hengrui Medicine Co., Ltd.), 5-fluorouracil (100mg / 10ml) (Jiangsu Hengrui Medicine Co., Ltd.), irinotecan hydrochloride for injection (40mg / bottle) (Jiangsu Hengrui Medicine Co., Ltd.) Hengrui Medicine Co., Ltd.), cyclophosphamide (20mg / bottle), methotrexate (50mg / bottle).

[0045] Dosing regimen:

[0046] The CT tumor-bearing BALB / c mice were divided into nine groups, and chemotherapy drugs such as irinotecan, oxaliplatin, 5-fluorouracil, cyclophosphamide and methotrexate were selected, and the chemotherapy drugs were injected intraperitoneally except for the blank group. Administer once a day, observe the survival status and defecation of the mice during the administration process, and finally evaluate the intestinal toxicity of the tumor-bearing mice caused by various chemotherapeutic drugs based on the survival rate and intestinal propulsion rate of the mice in each group ten days later. Administratio...

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Abstract

The invention provides a modeling method for adverse reactions of the digestive tract after chemotherapy, a model and application, and relates to the technical field of pharmacy. The modeling method for the adverse reactions of the digestive tract after chemotherapy comprises the steps of screening the administration dosage of chemotherapy medicine, conducting chemotherapy treatment on an animal tumor model according to the screened administration dosage, and obtaining the model for the adverse reactions of the digestive tract after chemotherapy, wherein with the administration dosage of the screened chemotherapy medicine, enterotoxicity evaluation is carried out on the animal tumor model treated by the chemotherapy medicine, and the digestive tract of the animal tumor model has the adverse reactions. Bad symptoms of the digestive tract in the model obtained by means of the method are caused by the chemotherapy medicine, so that when the model is used for researching and developing medicine for relieving the adverse reactions of the digestive tract after chemotherapy, the symptoms of the model are closer to actual pathological phenomena, accurate screening of the medicine and researching on the mechanism of the screened medicine for relieving the adverse reactions of the digestive tract after chemotherapy are facilitated.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a model building method, model and application of digestive tract adverse reactions after chemotherapy. Background technique [0002] Colon cancer is the most common malignant tumor in the digestive system, mainly occurring at the junction of the rectum and the sigmoid colon. In recent years, the incidence of colon cancer in developed countries in Europe and the United States accounts for the fourth place in the incidence of cancer, and the death rate is the second place. With the change of lifestyle, the number of patients with colon cancer in my country is constantly increasing. According to the epidemiological statistics, the rapid growth rate is 4.2% per year. The fourth place of tumor and cause of death has become one of the malignant tumors threatening the health of our people. The pathogenesis of colon cancer has not been fully elucidated. The main factors leading to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61K31/555A61K49/00
CPCA61K31/4745A61K31/555A61K49/0008
Inventor 金兆祥王琳张宇王玉晶范迪郭琳
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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